Neuroprotective effects of naringenin on nicotine-induced anxiety and depression: Involvement of monoaminergic systems, oxidative stress, and neuroinflammation on male rats [0.03%]
芸竹素对尼古丁致大鼠焦虑抑郁的神经保护作用及单胺能系统、氧化应激和神经炎症的介导机制研究
Murtaza Haidary,Yahya Samadi,Zakaria Rezai et al.
Murtaza Haidary et al.
Introduction: Nicotine withdrawal during adolescence induces severe neurobehavioral disturbances and neurochemical alterations, including anxiety, depression, affective dysregulation, oxidative stress, and neuroinflammati...
Dana F AlKharboush,Frank Kozielski,Geoffrey Wells et al.
Dana F AlKharboush et al.
Three decades after its introduction, fragment-based drug (or lead) discovery (FBDD or FBLD) has become a mature and powerful strategy for generating novel leads, offering distinct advantages for challenging or previously "undruggable" targ...
Salvianolic acid B decreases oxidative stress and alleviates the tumor-promoting effects of arecoline in oral cancer [0.03%]
salvianolic酸B减轻氧化应激并缓解Areca槟榔碱在口腔癌中的促肿瘤作用
Hsuan-Yin Tung,Yi-Ling Ye,Chi-Maw Lin et al.
Hsuan-Yin Tung et al.
Arecoline, which is a primary alkaloid in areca nuts, contributes in key ways to the development of oral submucous fibrosis and the subsequent oral cancer through the induction of oxidative stress, promotion of fibrosis, and activation of o...
Therapeutic effects of vitamin D and omega-3 supplementation on HFHS diet-induced endothelial dysfunction in Wistar rats [0.03%]
维生素D和ω-3脂肪酸补充对高脂高糖饮食诱导的血管内皮功能障碍大鼠的治疗作用研究
Dylan Le Jan,Sandrine Destrumelle,Chantal Thorin et al.
Dylan Le Jan et al.
Background: Obesity impairs cardiovascular health through endothelial dysfunction, which is exacerbated by high-fat high-sugar (HFHS) diets through mechanisms involving chronic inflammation, oxidative stress, and insulin ...
Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update [0.03%]
褪黑素联合抗肿瘤药物或天然产物治疗癌症：最新研究进展
Cristina Trejo-Solís,Irma Susana Rojas-Tomé,Helgi Jung-Cook et al.
Cristina Trejo-Solís et al.
Drug combinations have shown promise in suppressing drug resistance, improving drug efficacy, and reducing side effects in anticancer therapy. Considering that the anticancer activity of melatonin may be due to its antiproliferative, antiox...
MAO-B inhibition by selegiline blunts cardiac functions improved by high-fat diet: Role of inflammation, apoptosis, and calcium-handling [0.03%]
司来吉兰抑制多巴胺β-羟基酶会削弱高脂饮食对心脏功能的改善作用：炎症、凋亡和钙离子稳态的作用
Szabolcs Hambalkó,Csilla Pelyhe,Csenger Kovácsházi et al.
Szabolcs Hambalkó et al.
Background: Obesity is a major risk factor for the development of cardiovascular disease. However, recent research shows that moderate obesity reduces the risk of developing cardiovascular disease. We evidenced before tha...
Targeting telomere dynamics with plant-derived compounds: Molecular strategies against aging [0.03%]
植物衍生化合物靶向端粒动态：对抗衰老的分子策略
Raushanara Akter,Adwiza Chakraborty Bishakha,Raisha Rajib et al.
Raushanara Akter et al.
Telomeres, the repetitive DNA-protein complexes capping eukaryotic chromosomes, preserve genomic stability and regulate cellular replicative capacity. Progressive telomere shortening, coupled with diminished telomerase activity, is a hallma...
BCS II/IV antibiotics blended with SPEEK nanofibrous mat as an alternative for recurrent wound care: An in vitro and in vivo assessment [0.03%]
一种用于反复伤口护理的BCS II/IV抗生素与SPEEK纳米纤维素垫结合的备选方案：体外和体内评估
Himabindu Padinjarathil,Carmelo Drago,Sandro Dattilo et al.
Himabindu Padinjarathil et al.
The repeated dressing changes, especially for infected wounds and those with high exudate, and applying drugs daily, are huge demands in wound management. Sustained and regulated medication release of BCS II/IV antibiotics improves chronic ...
A 10-year interval of cardiovascular effects of albuterol in asthma management: Graphical review [0.03%]
支气管哮喘长期管理中沙丁胺醇心血管效应的十年变迁：图表回顾
Ghulam H Abbas,Faaizah Ahmed,Reda Iqbal et al.
Ghulam H Abbas et al.
Asthma is a widespread chronic respiratory disease that requires effective management to reduce exacerbations and improve patient outcomes. Albuterol (salbutamol), a short-acting beta-2-agonist (SABA), remains a mainstay treatment for acute...
Exploring the role of sex in asthma and COPD pharmacological treatment [0.03%]
探究性别在哮喘和慢性阻塞性肺疾病药物治疗中的作用
Luigino Calzetta,Shima Gholamalishahi,Elena Pistocchini et al.
Luigino Calzetta et al.
Sex is a fundamental determinant in pharmacology, influencing disease prevalence, severity, and therapeutic responses. Differences in pharmacokinetics and pharmacodynamics between men and women contribute to variations in drug efficacy and ...