Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing? [0.03%]
黄连素等森疗法药物可否用于与衰老相关的心血管病理状态的治疗？
Carmela Rita Balistreri,Rosalinda Madonna,Peter Ferdinandy
Carmela Rita Balistreri
It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particul...
Pharmacogenomics and circadian rhythms as mediators of cardiovascular drug-drug interactions [0.03%]
药理基因组学和昼夜节律在心血管药物相互作用中的介导作用
Yong-Jian Geng,Rosalinda Madonna,Ramon C Hermida et al.
Yong-Jian Geng et al.
This article summarizes the current literature and documents new evidence concerning drug-drug interactions (DDI) stemming from pharmacogenomic and circadian rhythm determinants of therapies used to treat common cardiovascular diseases (CVD...
Synthesis, molecular docking, and biological evaluation of Schiff base hybrids of 1,2,4-triazole-pyridine as dihydrofolate reductase inhibitors [0.03%]
作为二氢叶酸还原酶抑制剂的三唑-吡啶席夫碱杂化物的合成、分子对接和生物活性评估
D Dewangan,Y Vaishnav,A Mishra et al.
D Dewangan et al.
In this study novel derivatives of 1,2,4-triazole pyridine coupled with Schiff base were obtained in altered aromatic aldehyde and 4-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-ylthio)methyl)benzenamine reactions. Thin layer chromatography and me...
Effects of cytokine signaling inhibition on inflammation-driven tissue remodeling [0.03%]
细胞因子信号抑制对炎症驱动的组织重塑的影响
Rebecca Bignold,Jill R Johnson
Rebecca Bignold
Fibrosis is a common condition that can affect all body tissues, driven by unresolved tissue inflammation and resulting in tissue dysfunction and organ failure that could ultimately lead to death. A myriad of factors are thought to contribu...
Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders [0.03%]
评估药物相互作用和再利用在神经退行性疾病中的作用和影响
Dharmendra Kumar Khatri,Amey Kadbhane,Monica Patel et al.
Dharmendra Kumar Khatri et al.
Neurodegenerative diseases (ND) are of vast origin which are characterized by gradual progressive loss of neurons in the brain region. ND can be classified according to the clinical symptoms present (e.g. Cognitive decline, hyperkinetic, an...
Enhanced antihyperlipidemic potential of gemfibrozil under co-administration with piperine [0.03%]
胡椒碱联合吉非罗齐增敏降脂作用增强
S Mohanalakshmi,Shvetank Bhatt,C K Ashok Kumar
S Mohanalakshmi
Gemfibrozil is a well-known potent antihyperlipidemic drug with the capacity to lower triglyceride and cholesterol levels, which are responsible for most cardiovascular and cerebrovascular diseases. In addition, gemfibrozil has a potent act...
Drug-drug interactions in polypharmacy patients: The impact of renal impairment [0.03%]
肾功能损害在多重用药患者药物相互作用中的影响
Bianca Papotti,Cinzia Marchi,Maria Pia Adorni et al.
Bianca Papotti et al.
Chronic kidney disease (CKD) is a long-term condition characterized by a gradual loss of kidney functions, usually accompanied by other comorbidities including cardiovascular diseases (hypertension, heart failure and stroke) and diabetes me...
Tocotrienols-rich naringenin nanoemulgel for the management of diabetic wound: Fabrication, characterization and comparative in vitro evaluations [0.03%]
富托可三烯醇纳伦丁纳米乳凝胶的制备、表征及体外比较评价：糖尿病伤口管理疗法的新策略
Eileen Yeo,Clement Jia Yew Chieng,Hira Choudhury et al.
Eileen Yeo et al.
The present research had been attempted to formulate and characterize tocotrienols-rich naringenin nanoemulgel for topical application in chronic wound conditions associated with diabetes. In due course, different phases of the nanoemulsion...
Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice [0.03%]
减肥营养补充剂诱导的小鼠胃动力紊乱与serotonergic通路有关
Luciano N de Sousa,Débora S Paraguassú Sant&#x;ana,Rildo G Siqueira Dos Santos et al.
Luciano N de Sousa et al.
Fat burners are a category of nutritional supplements that are claimed to increase the metabolism and promote greater energy expenditure, leading to weight loss. However, little is known about the side effects on gastrointestinal motility. ...
Progress towards a clinically-successful ATR inhibitor for cancer therapy [0.03%]
开发临床有效的ATR抑制剂以用于癌症治疗的研究进展
Francis M Barnieh,Paul M Loadman,Robert A Falconer
Francis M Barnieh
The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonst...