Effects of cytokine signaling inhibition on inflammation-driven tissue remodeling [0.03%]
细胞因子信号抑制对炎症驱动的组织重塑的影响
Rebecca Bignold,Jill R Johnson
Rebecca Bignold
Fibrosis is a common condition that can affect all body tissues, driven by unresolved tissue inflammation and resulting in tissue dysfunction and organ failure that could ultimately lead to death. A myriad of factors are thought to contribu...
Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders [0.03%]
评估药物相互作用和再利用在神经退行性疾病中的作用和影响
Dharmendra Kumar Khatri,Amey Kadbhane,Monica Patel et al.
Dharmendra Kumar Khatri et al.
Neurodegenerative diseases (ND) are of vast origin which are characterized by gradual progressive loss of neurons in the brain region. ND can be classified according to the clinical symptoms present (e.g. Cognitive decline, hyperkinetic, an...
Enhanced antihyperlipidemic potential of gemfibrozil under co-administration with piperine [0.03%]
胡椒碱联合吉非罗齐增敏降脂作用增强
S Mohanalakshmi,Shvetank Bhatt,C K Ashok Kumar
S Mohanalakshmi
Gemfibrozil is a well-known potent antihyperlipidemic drug with the capacity to lower triglyceride and cholesterol levels, which are responsible for most cardiovascular and cerebrovascular diseases. In addition, gemfibrozil has a potent act...
Drug-drug interactions in polypharmacy patients: The impact of renal impairment [0.03%]
肾功能损害在多重用药患者药物相互作用中的影响
Bianca Papotti,Cinzia Marchi,Maria Pia Adorni et al.
Bianca Papotti et al.
Chronic kidney disease (CKD) is a long-term condition characterized by a gradual loss of kidney functions, usually accompanied by other comorbidities including cardiovascular diseases (hypertension, heart failure and stroke) and diabetes me...
Tocotrienols-rich naringenin nanoemulgel for the management of diabetic wound: Fabrication, characterization and comparative in vitro evaluations [0.03%]
富托可三烯醇纳伦丁纳米乳凝胶的制备、表征及体外比较评价：糖尿病伤口管理疗法的新策略
Eileen Yeo,Clement Jia Yew Chieng,Hira Choudhury et al.
Eileen Yeo et al.
The present research had been attempted to formulate and characterize tocotrienols-rich naringenin nanoemulgel for topical application in chronic wound conditions associated with diabetes. In due course, different phases of the nanoemulsion...
Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice [0.03%]
减肥营养补充剂诱导的小鼠胃动力紊乱与serotonergic通路有关
Luciano N de Sousa,Débora S Paraguassú Sant&#x;ana,Rildo G Siqueira Dos Santos et al.
Luciano N de Sousa et al.
Fat burners are a category of nutritional supplements that are claimed to increase the metabolism and promote greater energy expenditure, leading to weight loss. However, little is known about the side effects on gastrointestinal motility. ...
Progress towards a clinically-successful ATR inhibitor for cancer therapy [0.03%]
开发临床有效的ATR抑制剂以用于癌症治疗的研究进展
Francis M Barnieh,Paul M Loadman,Robert A Falconer
Francis M Barnieh
The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonst...
Joanna Woo,Cynthia Koziol-White,Reynold Panettieri Jr et al.
Joanna Woo et al.
Obesity is emerging as a global public health epidemic. The co-morbidities associated with obesity significantly contribute to reduced quality of life, mortality, and global healthcare burden. Compared to other asthma comorbidities, obesity...
Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents [0.03%]
包衣技术在时辰治疗给药系统中的应用：近期文献和专利回顾
Buduru Gowthami,S V Gopala Krishna,D Subba Rao
Buduru Gowthami
In general, extended release systems have the ability to maintain the drug concentration with in therapeutic range for prolonged period of time, but this may not be the primary requisite for circadian rhythm diseases like asthma, hypertensi...
Reversal of TGF-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma by sorafenib, a VEGFR-2 and Raf kinase inhibitor [0.03%]
索拉非尼逆转转化生长因子-β诱导的肝细胞癌上皮间质转换现象
Siddharth J Modi,Anshuly Tiwari,Vithal M Kulkarni
Siddharth J Modi
The epithelial-mesenchymal transition (EMT) is considered an essential process for cancer development and metastasis. Sorafenib, a RAF kinase and VEGFR-2 inhibitor, exhibits efficacy against advanced hepatocellular carcinoma (HCC), renal ca...