Screening of phytoconstituents of Andrographis paniculata against various targets of Japanese encephalitis virus: An in-silico and in-vitro target-based approach [0.03%]
印度草 ан多罗戈菲作为日本脑炎病毒各种靶标的植物成分筛选：基于目标的体外和计算机模拟研究
Shailesh Bhosale,Anoop Kumar
Shailesh Bhosale
Japanese encephalitis (JE) is one of the viral diseases affecting millions of peoples across the globe specifically developing countries. There is no specific treatment available, however, vaccines are available for its prevention. Unfortun...
Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment [0.03%]
已批准药物的新适应症再利用：解决银屑病治疗中的未满足需求
Harsha Jain,Aditi Rajan Bhat,Harshita Dalvi et al.
Harsha Jain et al.
Psoriasis is a chronic inflammatory autoimmune condition manifested by the hyperproliferation of keratinocytes with buildup of inflammatory red patches and scales on skin surfaces. The available treatment options for the management of psori...
Chronic administration of cryptolepine nanoparticle formulation alleviates seizures in a neurocysticercosis model [0.03%]
纳米粒子隐翅虫素慢性给药可缓解包虫病模型中的癫痫发作
Priscilla Kolibea Mante,Nana Ofori Adomako,Paulina Antwi et al.
Priscilla Kolibea Mante et al.
Worldwide, neurocysticercosis remains an important cause of acquired epilepsy. We therefore seek to investigate the effectiveness of the nanoparticle formulation of cryptolepine in alleviating seizures in a neurocysticercosis model. A solid...
Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes [0.03%]
特布他林慢性治疗增加培养的人类肌管的葡萄糖和油酸氧化以及蛋白质合成
Christine Skagen,Tuula A Nyman,Xiao-Rong Peng et al.
Christine Skagen et al.
Objective: In vivo studies have reported several beneficial metabolic effects of β-adrenergic receptor agonist administration in skeletal muscle, including increased glucose uptake, fatty acid metabolism, lipolysis and m...
Tuberculosis: Past, present and future of the treatment and drug discovery research [0.03%]
结核病：治疗和药物发现研究的过去、现在与未来
Ameya D Bendre,Peter J Peters,Janesh Kumar
Ameya D Bendre
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Despite decades of research driving advancements in drug development and discovery against TB, it still leads among the causes of deaths due to i...
From dissection of fibrotic pathways to assessment of drug interactions to reduce cardiac fibrosis and heart failure [0.03%]
从解析纤维化通路到评估药物相互作用以减少心脏纤维化和心力衰竭
Gloria Garoffolo,Maurizio Pesce
Gloria Garoffolo
Cardiac fibrosis is characterized by extracellular matrix deposition in the cardiac interstitium, and this contributes to cardiac contractile dysfunction and progression of heart failure. The main players involved in this process are the ca...
Suvranil Ghosh,Joyita Hazra,Koustav Pal et al.
Suvranil Ghosh et al.
Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. A geographic variation on the burden of the disease suggested that the environment, genetic makeup, lifestyle, and food habits modulate one's susceptibility...
Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions [0.03%]
靶向自噬治疗以调节年龄相关性疾病：成功、陷阱与新方向
Waleska Kerllen Martins,Maryana do Nascimento da Silva,Kiran Pandey et al.
Waleska Kerllen Martins et al.
Autophagy is a critical metabolic process that supports homeostasis at a basal level and is dynamically regulated in response to various physiological and pathological processes. Autophagy has some etiologic implications that support certai...
Drug interactions of direct oral anticoagulants in elderly patients with cardiometabolic diseases [0.03%]
心血管病患者使用直接口服抗凝药的药物相互作用——针对老年人群的研究
Alfonso Bellia,David Della-Morte,Nicola Di Daniele et al.
Alfonso Bellia et al.
In the present review we summarized current knowledge about significant interactions (DIs) of direct oral anticoagulants (DOACs) with other medications frequently prescribed to elderly patients with cardiometabolic diseases. Literature sear...
The potential roles of Nrf2/Keap1 signaling in anticancer drug interactions [0.03%]
Nrf2/Keap1信号通路在抗肿瘤药物相互作用中的潜在作用
Jingya Wang,Jin Yang,Mingnan Cao et al.
Jingya Wang et al.
Nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), together with its suppressive binding partner Kelch-like ECH-associated protein 1 (Keap1), regulates cellular antioxidant response and drug metabolism. The roles of Nrf2/Keap1 si...