Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes [0.03%]
特布他林慢性治疗增加培养的人类肌管的葡萄糖和油酸氧化以及蛋白质合成
Christine Skagen,Tuula A Nyman,Xiao-Rong Peng et al.
Christine Skagen et al.
Objective: In vivo studies have reported several beneficial metabolic effects of β-adrenergic receptor agonist administration in skeletal muscle, including increased glucose uptake, fatty acid metabolism, lipolysis and m...
Tuberculosis: Past, present and future of the treatment and drug discovery research [0.03%]
结核病：治疗和药物发现研究的过去、现在与未来
Ameya D Bendre,Peter J Peters,Janesh Kumar
Ameya D Bendre
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Despite decades of research driving advancements in drug development and discovery against TB, it still leads among the causes of deaths due to i...
From dissection of fibrotic pathways to assessment of drug interactions to reduce cardiac fibrosis and heart failure [0.03%]
从解析纤维化通路到评估药物相互作用以减少心脏纤维化和心力衰竭
Gloria Garoffolo,Maurizio Pesce
Gloria Garoffolo
Cardiac fibrosis is characterized by extracellular matrix deposition in the cardiac interstitium, and this contributes to cardiac contractile dysfunction and progression of heart failure. The main players involved in this process are the ca...
Suvranil Ghosh,Joyita Hazra,Koustav Pal et al.
Suvranil Ghosh et al.
Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. A geographic variation on the burden of the disease suggested that the environment, genetic makeup, lifestyle, and food habits modulate one's susceptibility...
Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions [0.03%]
靶向自噬治疗以调节年龄相关性疾病：成功、陷阱与新方向
Waleska Kerllen Martins,Maryana do Nascimento da Silva,Kiran Pandey et al.
Waleska Kerllen Martins et al.
Autophagy is a critical metabolic process that supports homeostasis at a basal level and is dynamically regulated in response to various physiological and pathological processes. Autophagy has some etiologic implications that support certai...
Drug interactions of direct oral anticoagulants in elderly patients with cardiometabolic diseases [0.03%]
心血管病患者使用直接口服抗凝药的药物相互作用——针对老年人群的研究
Alfonso Bellia,David Della-Morte,Nicola Di Daniele et al.
Alfonso Bellia et al.
In the present review we summarized current knowledge about significant interactions (DIs) of direct oral anticoagulants (DOACs) with other medications frequently prescribed to elderly patients with cardiometabolic diseases. Literature sear...
The potential roles of Nrf2/Keap1 signaling in anticancer drug interactions [0.03%]
Nrf2/Keap1信号通路在抗肿瘤药物相互作用中的潜在作用
Jingya Wang,Jin Yang,Mingnan Cao et al.
Jingya Wang et al.
Nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), together with its suppressive binding partner Kelch-like ECH-associated protein 1 (Keap1), regulates cellular antioxidant response and drug metabolism. The roles of Nrf2/Keap1 si...
Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing? [0.03%]
黄连素等森疗法药物可否用于与衰老相关的心血管病理状态的治疗？
Carmela Rita Balistreri,Rosalinda Madonna,Peter Ferdinandy
Carmela Rita Balistreri
It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particul...
Pharmacogenomics and circadian rhythms as mediators of cardiovascular drug-drug interactions [0.03%]
药理基因组学和昼夜节律在心血管药物相互作用中的介导作用
Yong-Jian Geng,Rosalinda Madonna,Ramon C Hermida et al.
Yong-Jian Geng et al.
This article summarizes the current literature and documents new evidence concerning drug-drug interactions (DDI) stemming from pharmacogenomic and circadian rhythm determinants of therapies used to treat common cardiovascular diseases (CVD...
Synthesis, molecular docking, and biological evaluation of Schiff base hybrids of 1,2,4-triazole-pyridine as dihydrofolate reductase inhibitors [0.03%]
作为二氢叶酸还原酶抑制剂的三唑-吡啶席夫碱杂化物的合成、分子对接和生物活性评估
D Dewangan,Y Vaishnav,A Mishra et al.
D Dewangan et al.
In this study novel derivatives of 1,2,4-triazole pyridine coupled with Schiff base were obtained in altered aromatic aldehyde and 4-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-ylthio)methyl)benzenamine reactions. Thin layer chromatography and me...