Interaction of obtusilactone B and related butanolide lactones with the barrier-to-autointegration factor 1 (BAF1). A computational study [0.03%]
牛扁素B和相关丁内酯内酯与屏障自整合因子1（BAF1）的相互作用。一项计算研究
Christian Bailly,Gérard Vergoten
Christian Bailly
The barrier-to-autointegration factor 1 (BAF1) protein is a DNA-binding protein implicated in nuclear envelop repair and reformation after mitosis. This nuclear protein is frequently overexpressed in cancer cells and plays a role in the occ...
Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms [0.03%]
基于纳米载体的药物传输平台克服P-糖蛋白介导的多药耐药性乳腺癌的新视野研究
Paras Famta,Saurabh Shah,Essha Chatterjee et al.
Paras Famta et al.
The high probability (13%) of women developing breast cancer in their lifetimes in America is exacerbated by the emergence of multidrug resistance after exposure to first-line chemotherapeutic agents. Permeation glycoprotein (P-gp)-mediated...
Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm [0.03%]
Apratoxin S4抑制共翻译转运：对致癌受体酪氨酸激酶和细胞质中产生的跨膜蛋白命运的影响
Weijing Cai,Ranjala Ratnayake,Mengxiong Wang et al.
Weijing Cai et al.
Receptor tyrosine kinases (RTKs) have become major targets for anticancer therapy. However, resistance and signaling pathway redundancy has been problematic. The marine-derived apratoxins act complementary to direct kinase inhibitors by dow...
Protective effect of co-administration of caffeine and piracetam on scopolamine-induced amnesia in Wistar rats [0.03%]
咖啡因和哌甲酯联合给药对Wistar大鼠东莨菪碱致健忘的保护作用研究
Subhash Chaturvedi,Aditya Ganeshpurkar,Abhishek Shrivastava et al.
Subhash Chaturvedi et al.
Alzheimer's disease is a cerebrovascular disorder characterized by progressive loss of the mental capabilities. The novel therapeutic agent piracetam is a cyclic derivative of γ-aminobutyric acid and one of the oldest recognized synthetic ...
ATP citrate lyase inhibitor Bempedoic Acid alleviate long term HFD induced NASH through improvement in glycemic control, reduction of hepatic triglycerides & total cholesterol, modulation of inflammatory & fibrotic genes and improvement in NAS score [0.03%]
ATP柠檬酸裂解酶抑制剂Bempedoic Acid通过改善糖耐量、降低肝脏甘油三酯和总胆固醇水平、调节炎症及纤维化相关基因的表达以及改善NASH病理评分来缓解长期高脂饮食诱导的NASH
K V Sanjay,Santosh Vishwakarma,Bharat Ravindra Zope et al.
K V Sanjay et al.
Non-alcoholic fatty liver disease (NAFLD) and Non-alcoholic steatohepatitis (NASH) are chronic liver disorders, the prevalence of which is increasing worldwide. Long term High Fat Diet (HFD) induced NASH animal models closely mimic the char...
Jignesh Prajapati,Dweipayan Goswami,Rakesh M Rawal
Jignesh Prajapati
Cancer is a multifactorial disease with a convoluted genesis and progression. The emergence of multidrug resistance to presently be offered drug and relapse is by far, the most critical concern to tackle this deteriorating disease. Hencefor...
Mitochondrial dysfunction and oxidative stress are involved in the mechanism of tramadol-induced renal injury [0.03%]
tramadol引起的肾脏损伤与线粒体功能障碍和氧化应激有关
Khadijah Mousavi,Ram Kumar Manthari,Asma Najibi et al.
Khadijah Mousavi et al.
Tramadol (TMDL) is an opioid analgesic widely administered for the management of moderate to severe pain. On the other hand, TMDL is commonly abused in many countries because of its availability and cheap cost. Renal injury is related to hi...
Kuleshwar Sahu,Urvashi Langeh,Charan Singh et al.
Kuleshwar Sahu et al.
Chemotherapy is an important component of cancer treatment, which has side effects like vomiting, peripheral neuropathy, and numerous organ toxicity but the most significant outcomes of chemotherapy are cognitive impairment, which is mainly...
Pharmacological interactions: Synergism, or not synergism, that is the question [0.03%]
药理学相互作用：协同作用，还是非协同作用，这是一个问题
Luigino Calzetta,Cynthia Koziol-White
Luigino Calzetta
Pharmacokinetic drug interactions of integrase strand transfer inhibitors [0.03%]
整合酶链转移抑制剂的药代动力学药物相互作用
Chi-Hua Lu,Edward M Bednarczyk,Linda M Catanzaro et al.
Chi-Hua Lu et al.
The integrase strand transfer inhibitor (INSTI)-containing regimens are currently considered as the first-line treatment of human immunodeficiency virus (HIV) infection. Although possessing a common mechanism of action to inhibit HIV integr...