Protective effect of co-administration of caffeine and piracetam on scopolamine-induced amnesia in Wistar rats [0.03%]
咖啡因和哌甲酯联合给药对Wistar大鼠东莨菪碱致健忘的保护作用研究
Subhash Chaturvedi,Aditya Ganeshpurkar,Abhishek Shrivastava et al.
Subhash Chaturvedi et al.
Alzheimer's disease is a cerebrovascular disorder characterized by progressive loss of the mental capabilities. The novel therapeutic agent piracetam is a cyclic derivative of γ-aminobutyric acid and one of the oldest recognized synthetic ...
ATP citrate lyase inhibitor Bempedoic Acid alleviate long term HFD induced NASH through improvement in glycemic control, reduction of hepatic triglycerides & total cholesterol, modulation of inflammatory & fibrotic genes and improvement in NAS score [0.03%]
ATP柠檬酸裂解酶抑制剂Bempedoic Acid通过改善糖耐量、降低肝脏甘油三酯和总胆固醇水平、调节炎症及纤维化相关基因的表达以及改善NASH病理评分来缓解长期高脂饮食诱导的NASH
K V Sanjay,Santosh Vishwakarma,Bharat Ravindra Zope et al.
K V Sanjay et al.
Non-alcoholic fatty liver disease (NAFLD) and Non-alcoholic steatohepatitis (NASH) are chronic liver disorders, the prevalence of which is increasing worldwide. Long term High Fat Diet (HFD) induced NASH animal models closely mimic the char...
Jignesh Prajapati,Dweipayan Goswami,Rakesh M Rawal
Jignesh Prajapati
Cancer is a multifactorial disease with a convoluted genesis and progression. The emergence of multidrug resistance to presently be offered drug and relapse is by far, the most critical concern to tackle this deteriorating disease. Hencefor...
Mitochondrial dysfunction and oxidative stress are involved in the mechanism of tramadol-induced renal injury [0.03%]
tramadol引起的肾脏损伤与线粒体功能障碍和氧化应激有关
Khadijah Mousavi,Ram Kumar Manthari,Asma Najibi et al.
Khadijah Mousavi et al.
Tramadol (TMDL) is an opioid analgesic widely administered for the management of moderate to severe pain. On the other hand, TMDL is commonly abused in many countries because of its availability and cheap cost. Renal injury is related to hi...
Kuleshwar Sahu,Urvashi Langeh,Charan Singh et al.
Kuleshwar Sahu et al.
Chemotherapy is an important component of cancer treatment, which has side effects like vomiting, peripheral neuropathy, and numerous organ toxicity but the most significant outcomes of chemotherapy are cognitive impairment, which is mainly...
Pharmacological interactions: Synergism, or not synergism, that is the question [0.03%]
药理学相互作用：协同作用，还是非协同作用，这是一个问题
Luigino Calzetta,Cynthia Koziol-White
Luigino Calzetta
Pharmacokinetic drug interactions of integrase strand transfer inhibitors [0.03%]
整合酶链转移抑制剂的药代动力学药物相互作用
Chi-Hua Lu,Edward M Bednarczyk,Linda M Catanzaro et al.
Chi-Hua Lu et al.
The integrase strand transfer inhibitor (INSTI)-containing regimens are currently considered as the first-line treatment of human immunodeficiency virus (HIV) infection. Although possessing a common mechanism of action to inhibit HIV integr...
Screening of phytoconstituents of Andrographis paniculata against various targets of Japanese encephalitis virus: An in-silico and in-vitro target-based approach [0.03%]
印度草 ан多罗戈菲作为日本脑炎病毒各种靶标的植物成分筛选：基于目标的体外和计算机模拟研究
Shailesh Bhosale,Anoop Kumar
Shailesh Bhosale
Japanese encephalitis (JE) is one of the viral diseases affecting millions of peoples across the globe specifically developing countries. There is no specific treatment available, however, vaccines are available for its prevention. Unfortun...
Repurposing approved therapeutics for new indication: Addressing unmet needs in psoriasis treatment [0.03%]
已批准药物的新适应症再利用：解决银屑病治疗中的未满足需求
Harsha Jain,Aditi Rajan Bhat,Harshita Dalvi et al.
Harsha Jain et al.
Psoriasis is a chronic inflammatory autoimmune condition manifested by the hyperproliferation of keratinocytes with buildup of inflammatory red patches and scales on skin surfaces. The available treatment options for the management of psori...
Chronic administration of cryptolepine nanoparticle formulation alleviates seizures in a neurocysticercosis model [0.03%]
纳米粒子隐翅虫素慢性给药可缓解包虫病模型中的癫痫发作
Priscilla Kolibea Mante,Nana Ofori Adomako,Paulina Antwi et al.
Priscilla Kolibea Mante et al.
Worldwide, neurocysticercosis remains an important cause of acquired epilepsy. We therefore seek to investigate the effectiveness of the nanoparticle formulation of cryptolepine in alleviating seizures in a neurocysticercosis model. A solid...