Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1α and HIF-2α [0.03%]
缺氧通过独立于HIF-1α和HIF-2α的作用抑制前列腺癌和肾癌细胞对YM155的早期反应
David Danielpour,Sarah Corum,Scott M Welford et al.
David Danielpour et al.
The imidazolium compound Sepantronium Bromide (YM155) successfully promotes tumor regression in various pre-clinical models but has shown modest responses in human clinical trials. We provide evidence to support that the hypoxic milieu of t...
Kayla Simon,Hunter Sheckley,Christopher L Anderson et al.
Kayla Simon et al.
Introduction: Dravet Syndrome (DS) is a rare epileptiform disorder typically presenting within the first year of life of a normally developing infant. It is characterized by several prolonged seizures that are often resis...
When disease extent is not always a key parameter: Management of refractory ulcerative proctitis [0.03%]
当病情范围并非总是关键参数时：难治性溃疡性直肠炎的治疗
Georgios Michalopoulos,Konstantinos Karmiris
Georgios Michalopoulos
Background: Patients with ulcerative proctitis represent a sub-group of ulcerative colitis patients with specific characteristics. Disease-related symptoms, endoscopic findings and patient's personality perspectives creat...
Joana Revés,Ryan C Ungaro,Joana Torres
Joana Revés
Despite the recent developments in the diagnosis and management of inflammatory bowel diseases (IBD), patients still suffer from disabling bowel symptoms and significant disease complications and many questions remain to improve their care....
Secretome effect of adipose tissue-derived stem cells cultured two-dimensionally and three-dimensionally in mice with streptozocin induced type 1 diabetes [0.03%]
二维和三维培养的脂肪源间充质干细胞分泌组对链脲佐菌素诱导的Ⅰ型糖尿病小鼠的影响
Isabelle Dias,Daphne Pinheiro,Karina Ribeiro Silva et al.
Isabelle Dias et al.
Aims: To analyze therapeutic potential of the conditioned medium from adipose tissue-derived stem cells (ASC) cultivated in 2D (CM-2D) and 3D (CM-3D) models, in mice with Type 1 diabetes (T1D) induced by streptozotocin. ...
[This corrects the article DOI: 10.1016/j.crphar.2021.100025.][This corrects the article DOI: 10.1016/j.crphar.2020.100013.][This corrects the article DOI: 10.1016/j.crphar.2020.100009.][This corrects the article DOI: 10.1016/j.crphar.2020....
Supramolecular lipid nanoparticles as delivery carriers for non-invasive cancer theranostics [0.03%]
超分子脂质纳米颗粒作为非侵入癌症诊疗的递送载体
Syeda Zunaira Bukhari,Kornelius Zeth,Maryam Iftikhar et al.
Syeda Zunaira Bukhari et al.
Nanotheranostics is an emerging frontier of personalized medicine research particularly for cancer, which is the second leading cause of death. Supramolecular aspects in theranostics are quite allured to achieve more regulation and controll...
Bupivacaine in combination with sildenafil (Viagra) and vitamin D3 have anti-inflammatory effects in osteoarthritic chondrocytes [0.03%]
布比卡因联合西地那非（万艾可）和维生素D3对骨关节炎软骨细胞的抗炎作用
Elisabeth Hansson,Eva Skiöldebrand
Elisabeth Hansson
Aims: To treat osteoarthritic chondrocytes and thereby reduce the inflammation with a drug combination that primarily affects 5-HT- and ATP-evoked Ca2+ signaling. In osteoarthritic chondrocytes, Ca2+ signaling is elevated...
SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells [0.03%]
SENP2对于人类骨骼肌细胞的胰岛素信号传导和胰岛素刺激的糖原合成至关重要
Jenny Lund,Solveig A Krapf,Medina Sistek et al.
Jenny Lund et al.
Sentrin-specific protease (SENP) 2 has been suggested as a possible novel drug target for the treatment of obesity and type 2 diabetes mellitus after observations of a palmitate-induced increase in SENP2 that lead to increased fatty acid ox...
The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells [0.03%]
一种名为CDN1163的SERCA小分子激活剂可增强人体骨骼肌细胞的能量代谢
Abel M Mengeste,Jenny Lund,Parmeshwar Katare et al.
Abel M Mengeste et al.
Background and objective: A number of studies have highlighted muscle-specific mechanisms of thermogenesis involving futile cycling of Ca2+ driven by sarco (endo)plasmic reticulum Ca2+-ATPase (SERCA) and generating heat f...