Joana Revés,Ryan C Ungaro,Joana Torres
Joana Revés
Despite the recent developments in the diagnosis and management of inflammatory bowel diseases (IBD), patients still suffer from disabling bowel symptoms and significant disease complications and many questions remain to improve their care....
Secretome effect of adipose tissue-derived stem cells cultured two-dimensionally and three-dimensionally in mice with streptozocin induced type 1 diabetes [0.03%]
二维和三维培养的脂肪源间充质干细胞分泌组对链脲佐菌素诱导的Ⅰ型糖尿病小鼠的影响
Isabelle Dias,Daphne Pinheiro,Karina Ribeiro Silva et al.
Isabelle Dias et al.
Aims: To analyze therapeutic potential of the conditioned medium from adipose tissue-derived stem cells (ASC) cultivated in 2D (CM-2D) and 3D (CM-3D) models, in mice with Type 1 diabetes (T1D) induced by streptozotocin. ...
[This corrects the article DOI: 10.1016/j.crphar.2021.100025.][This corrects the article DOI: 10.1016/j.crphar.2020.100013.][This corrects the article DOI: 10.1016/j.crphar.2020.100009.][This corrects the article DOI: 10.1016/j.crphar.2020....
Supramolecular lipid nanoparticles as delivery carriers for non-invasive cancer theranostics [0.03%]
超分子脂质纳米颗粒作为非侵入癌症诊疗的递送载体
Syeda Zunaira Bukhari,Kornelius Zeth,Maryam Iftikhar et al.
Syeda Zunaira Bukhari et al.
Nanotheranostics is an emerging frontier of personalized medicine research particularly for cancer, which is the second leading cause of death. Supramolecular aspects in theranostics are quite allured to achieve more regulation and controll...
Bupivacaine in combination with sildenafil (Viagra) and vitamin D3 have anti-inflammatory effects in osteoarthritic chondrocytes [0.03%]
布比卡因联合西地那非（万艾可）和维生素D3对骨关节炎软骨细胞的抗炎作用
Elisabeth Hansson,Eva Skiöldebrand
Elisabeth Hansson
Aims: To treat osteoarthritic chondrocytes and thereby reduce the inflammation with a drug combination that primarily affects 5-HT- and ATP-evoked Ca2+ signaling. In osteoarthritic chondrocytes, Ca2+ signaling is elevated...
SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells [0.03%]
SENP2对于人类骨骼肌细胞的胰岛素信号传导和胰岛素刺激的糖原合成至关重要
Jenny Lund,Solveig A Krapf,Medina Sistek et al.
Jenny Lund et al.
Sentrin-specific protease (SENP) 2 has been suggested as a possible novel drug target for the treatment of obesity and type 2 diabetes mellitus after observations of a palmitate-induced increase in SENP2 that lead to increased fatty acid ox...
The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells [0.03%]
一种名为CDN1163的SERCA小分子激活剂可增强人体骨骼肌细胞的能量代谢
Abel M Mengeste,Jenny Lund,Parmeshwar Katare et al.
Abel M Mengeste et al.
Background and objective: A number of studies have highlighted muscle-specific mechanisms of thermogenesis involving futile cycling of Ca2+ driven by sarco (endo)plasmic reticulum Ca2+-ATPase (SERCA) and generating heat f...
Interaction of obtusilactone B and related butanolide lactones with the barrier-to-autointegration factor 1 (BAF1). A computational study [0.03%]
牛扁素B和相关丁内酯内酯与屏障自整合因子1（BAF1）的相互作用。一项计算研究
Christian Bailly,Gérard Vergoten
Christian Bailly
The barrier-to-autointegration factor 1 (BAF1) protein is a DNA-binding protein implicated in nuclear envelop repair and reformation after mitosis. This nuclear protein is frequently overexpressed in cancer cells and plays a role in the occ...
Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms [0.03%]
基于纳米载体的药物传输平台克服P-糖蛋白介导的多药耐药性乳腺癌的新视野研究
Paras Famta,Saurabh Shah,Essha Chatterjee et al.
Paras Famta et al.
The high probability (13%) of women developing breast cancer in their lifetimes in America is exacerbated by the emergence of multidrug resistance after exposure to first-line chemotherapeutic agents. Permeation glycoprotein (P-gp)-mediated...
Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm [0.03%]
Apratoxin S4抑制共翻译转运：对致癌受体酪氨酸激酶和细胞质中产生的跨膜蛋白命运的影响
Weijing Cai,Ranjala Ratnayake,Mengxiong Wang et al.
Weijing Cai et al.
Receptor tyrosine kinases (RTKs) have become major targets for anticancer therapy. However, resistance and signaling pathway redundancy has been problematic. The marine-derived apratoxins act complementary to direct kinase inhibitors by dow...