GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells [0.03%]
GSK2606414通过削弱PERK/p-eIF2α/ATF4/CHOP轴并增强线粒体功能来减轻高糖诱导的神经毒性：N2A细胞研究
Chayanika Gundu,Vijay Kumar Arruri,Bhoomika Sherkhane et al.
Chayanika Gundu et al.
Neuronal dysfunction and subsequent apoptosis under high glucose conditions during diabetes contribute majorly to the manifestation of diabetic peripheral neuropathy (DPN). PERK (protein kinase RNA (PKR)-like ER kinase) one among the three ...
Variability in the serum and tissue concentrations of pre-incisional ceftriaxone for surgery in paediatric population and outcome of surgical-site infections; An open labelled, prospective, non-randomized, analytical study [0.03%]
术前头孢曲松在儿科手术患者中的血清和组织浓度的变异性及其对手术部位感染结局的影响：一项开放性、前瞻性、非随机分析研究
Salim Sheikh,Ravinder Majoka,Chakra Dhar Tripathi et al.
Salim Sheikh et al.
Studies have determined the serum concentration of ceftriaxone in the adult population, but there are only a few studies that measured the tissue concentrations. However, no studies have concurrently evaluated the serum and tissue concentra...
Debdoot Basu,Vivek P Chavda,Anita A Mehta
Debdoot Basu
Since its inception in late December 2020 in China, novel coronavirus has affected the global socio-economic aspect. Currently, the world is seeking safe and effective treatment measures against COVID-19 to eradicate it. Many established dr...
Fabrication and evaluation of mannose decorated curcumin loaded nanostructured lipid carriers for hepatocyte targeting: In vivo hepatoprotective activity in Wistar rats [0.03%]
一种用于肝细胞靶向的新型姜黄素纳米结构脂质载体的制备及评价：Wistar大鼠体内保肝活性研究
Manish Kumar Gupta,Vipul Sansare,Birendra Shrivastava et al.
Manish Kumar Gupta et al.
Curcumin is a well-recognized antioxidant phytoactive isolated from the rhizomes of Curcuma longa. Numerous landmark investigations have proved the antioxidant and hepatoprotective potential of curcumin. The aim of present study was to targ...
Investigation of the cytotoxicity induced by didocosahexaenoin, an omega 3 derivative, in human prostate carcinoma cell lines [0.03%]
狄多科沙六烯醇诱导人前列腺癌细胞系毒性的研究
Glenn F Robinson,Kartheek Ky Sooda,Roger M Phillips et al.
Glenn F Robinson et al.
The aim of the present study was to investigate the cytotoxicity induced by an omega-3 derivative, didocosahexaenoin (Dido) on human prostate carcinoma cells and to compare the cytotoxicity to that of docosahexaenoic acid (DHA). Different c...
Inhalation potential of N-Acetylcysteine loaded PLGA nanoparticles for the management of tuberculosis: In vitro lung deposition and efficacy studies [0.03%]
负载N-乙酰半胱氨酸的PLGA纳米颗粒吸入治疗结核病的潜力：体外肺沉积和疗效研究
Vishal Puri,Kabi Raj Chaudhary,Arti Singh et al.
Vishal Puri et al.
Several studies have stated that mucus is a critical hurdle for drug delivery to the mucosal tissues. As a result, Polymeric nanoparticles that can overcome mucus barriers are gaining popularity for controlled drug delivery into intra-macro...
Managing complex perianal disease after anti-TNF failure: Where to go next? [0.03%]
抗TNF治疗失败后的复杂肛周疾病如何进行下一步治疗？
Clare Yzet,Franck Brazier,Charles Sabbagh et al.
Clare Yzet et al.
Crohn's disease is a chronic inflammatory bowel disease that affects various intestinal segments and can involve the perianal region. Although anti-tumor necrosis factor (TNF) agents have revolutionized the management of Crohn's disease and...
Comparative differential cytotoxicity of clinically used SERMs in human cancer lines of different origin and its predictive molecular docking studies of key target genes involved in cancer progression and treatment responses [0.03%]
临床使用的选择性雌激素受体调节剂对不同来源的人类癌细胞系的差异细胞毒性比较及其关键靶基因在癌症发展和治疗反应中的预测分子对接研究
Lakshmi S,Shanitha A,Shiny Dv et al.
Lakshmi S et al.
SERMS like Tamoxifene, 5-hydroxy tamoxifene, raloxifene and endoxifene has been used for the treatment of hormonal imbalances and dependent cancers owing to their action via Estrogen receptors as in the treatment of estrogen sensitive breas...
Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers [0.03%]
唾液糖蛋白岩藻糖基化和唾液酸化的异常：肺癌特异性标志物的特征
Ziyuan Gao,Mingming Xu,Shuang Yue et al.
Ziyuan Gao et al.
Dysregulated surface glycoproteins play an important role in tumor cell proliferation and progression. Abnormal glycosylation of these glycoproteins may activate tumor signal transduction and lead to tumor development. The tumor microenviro...
Safety of rapid intravenous paracetamol infusion in paediatric patients [0.03%]
儿童患者快速静脉注射对乙酰氨基酚的安全性
Astrid Eliasen,Sigrid Otnes,Merete Matz et al.
Astrid Eliasen et al.
Purpose: Paracetamol is recommended as a first-line treatment for pain and fever in paediatric patients. Intravenous (IV) infusions are recommended to be administered as a 15-min infusion to minimize local tissue trauma a...