Maia Kayal,Marla C Dubinsky
Maia Kayal
Image 1. Keywords: Pouch; Pouchitis; Proctocolectomy; Ulcerative colitis. © 2022 The A...
Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome [0.03%]
微球蕨根茎中富 Lectin 提取物的抗菌和抗肿瘤活性研究
Gabriela Cavalcante da Silva,Alisson Macário de Oliveira,Wêndeo Kennedy Costa et al.
Gabriela Cavalcante da Silva et al.
The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate...
The future of inhalation therapy in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病的吸入疗法的未来展望
Mario Cazzola,Josuel Ora,Luigino Calzetta et al.
Mario Cazzola et al.
The inhaled route is critical for the administration of drugs to treat patients suffering from COPD, but there is still an unmet need for new and innovative inhalers to address some limitations of existing products that do not make them sui...
Dihydroquercetin ameliorates LPS-induced neuroinflammation and memory deficit [0.03%]
儿茶素茋通过改善内毒素引起的神经炎症和记忆损害治疗认知障碍疾病
Qadir Alam,Sairam Krishnamurthy
Qadir Alam
Dihydroquercetin (DHQ) is a pentahydroxyflavanone that has been used as an important suppliment against oxidative stress related inflammation and neuroinflammation. Neuroinflammation, which is the activation of the defense mechanism of the ...
A saponin-polybromophenol antibiotic (CU1) from Cassia fistula Bark Against Multi-Drug Resistant Bacteria Targeting RNA polymerase [0.03%]
来源于金合欢苦皮藤提取物的皂苷-多溴苯酚抗生素(CU1)通过靶向RNA聚合酶对抗耐药菌
Asit Kumar Chakraborty,Sourajit Saha,Kousik Poria et al.
Asit Kumar Chakraborty et al.
Background: Gradual increase of multidrug resistant infections is a threat to the human race as MDR plasmids have acquired.>10 mdr and drug efflux genes to inactivate antibiotics. Plants secret anti-metabolites to retard ...
Biomarker discovery for personalized therapy selection in inflammatory bowel diseases: Challenges and promises [0.03%]
炎症性肠病个性化治疗选择的生物标志物发现：挑战与展望
Dahham Alsoud,Séverine Vermeire,Bram Verstockt
Dahham Alsoud
The past decades witnessed a significant stride in deciphering the pathophysiology of inflammatory bowel disease, which further advanced drug development adding several new biologicals and small molecules to the arsenal of available therapi...
Simvastatin ameliorates oxidative stress levels in HepG2 cells and hyperlipidemic rats [0.03%]
辛伐他汀改善HepG2细胞和高脂血症大鼠的氧化应激水平
Kanika Verma,Shikha Makwana,Sarvesh Paliwal et al.
Kanika Verma et al.
Simvastatin is an established anti-hyperlipidemic drug and few studies have indicated its role in the mitigation of oxidative stress. However, a systematic study considering molecular binding/interaction of simvastatin with anti-oxidant enz...
GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells [0.03%]
GSK2606414通过削弱PERK/p-eIF2α/ATF4/CHOP轴并增强线粒体功能来减轻高糖诱导的神经毒性：N2A细胞研究
Chayanika Gundu,Vijay Kumar Arruri,Bhoomika Sherkhane et al.
Chayanika Gundu et al.
Neuronal dysfunction and subsequent apoptosis under high glucose conditions during diabetes contribute majorly to the manifestation of diabetic peripheral neuropathy (DPN). PERK (protein kinase RNA (PKR)-like ER kinase) one among the three ...
Variability in the serum and tissue concentrations of pre-incisional ceftriaxone for surgery in paediatric population and outcome of surgical-site infections; An open labelled, prospective, non-randomized, analytical study [0.03%]
术前头孢曲松在儿科手术患者中的血清和组织浓度的变异性及其对手术部位感染结局的影响：一项开放性、前瞻性、非随机分析研究
Salim Sheikh,Ravinder Majoka,Chakra Dhar Tripathi et al.
Salim Sheikh et al.
Studies have determined the serum concentration of ceftriaxone in the adult population, but there are only a few studies that measured the tissue concentrations. However, no studies have concurrently evaluated the serum and tissue concentra...
Debdoot Basu,Vivek P Chavda,Anita A Mehta
Debdoot Basu
Since its inception in late December 2020 in China, novel coronavirus has affected the global socio-economic aspect. Currently, the world is seeking safe and effective treatment measures against COVID-19 to eradicate it. Many established dr...