Ileal and colonic Crohn's disease: Does location makes a difference in therapy efficacy? [0.03%]
肠和回肠克罗恩病：位置对治疗效果有影响吗？
Raja Atreya,Christian Bojarski,Anja A Kühl et al.
Raja Atreya et al.
Within the IBD entity of Crohn's disease, there is currently no differentiation between ileal and colonic manifestation for recruitment of patients in clinical trials, well-powered analysis of study results or therapeutic decisions in daily...
Regulation of bFGF-induced effects on rat aortic smooth muscle cells by β3-adrenergic receptors [0.03%]
β3-肾上腺素受体对bFGF作用于大鼠主动脉平滑肌细胞的调节作用
Yingzi Chang,Lei Alena Dagat,Aisha Yusuf et al.
Yingzi Chang et al.
Background: Basic fibroblast growth factor (bFGF)-mediated vascular smooth muscle cell (VSMC) proliferation and migration play an important role in vascular injury-induced neointima formation and subsequent vascular reste...
Ted A Spiewak,Anish Patel
Ted A Spiewak
Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD), are remitting and relapsing disorders of the gastrointestinal tract, highlighted by the dysregulation of pro- and anti-inflammatory mediators, which...
Maia Kayal,Marla C Dubinsky
Maia Kayal
Image 1. Keywords: Pouch; Pouchitis; Proctocolectomy; Ulcerative colitis. © 2022 The A...
Antibacterial and antitumor activities of a lectin-rich preparation from Microgramma vacciniifolia rhizome [0.03%]
微球蕨根茎中富 Lectin 提取物的抗菌和抗肿瘤活性研究
Gabriela Cavalcante da Silva,Alisson Macário de Oliveira,Wêndeo Kennedy Costa et al.
Gabriela Cavalcante da Silva et al.
The rhizome of Microgramma vacciniifolia contains a lectin (carbohydrate-binding protein) called MvRL. Studies demonstrated that a MvRL-rich fraction did not show in vivo genotoxicity and acute toxicity in mice. This study aimed to evaluate...
The future of inhalation therapy in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病的吸入疗法的未来展望
Mario Cazzola,Josuel Ora,Luigino Calzetta et al.
Mario Cazzola et al.
The inhaled route is critical for the administration of drugs to treat patients suffering from COPD, but there is still an unmet need for new and innovative inhalers to address some limitations of existing products that do not make them sui...
Dihydroquercetin ameliorates LPS-induced neuroinflammation and memory deficit [0.03%]
儿茶素茋通过改善内毒素引起的神经炎症和记忆损害治疗认知障碍疾病
Qadir Alam,Sairam Krishnamurthy
Qadir Alam
Dihydroquercetin (DHQ) is a pentahydroxyflavanone that has been used as an important suppliment against oxidative stress related inflammation and neuroinflammation. Neuroinflammation, which is the activation of the defense mechanism of the ...
A saponin-polybromophenol antibiotic (CU1) from Cassia fistula Bark Against Multi-Drug Resistant Bacteria Targeting RNA polymerase [0.03%]
来源于金合欢苦皮藤提取物的皂苷-多溴苯酚抗生素(CU1)通过靶向RNA聚合酶对抗耐药菌
Asit Kumar Chakraborty,Sourajit Saha,Kousik Poria et al.
Asit Kumar Chakraborty et al.
Background: Gradual increase of multidrug resistant infections is a threat to the human race as MDR plasmids have acquired.>10 mdr and drug efflux genes to inactivate antibiotics. Plants secret anti-metabolites to retard ...
Biomarker discovery for personalized therapy selection in inflammatory bowel diseases: Challenges and promises [0.03%]
炎症性肠病个性化治疗选择的生物标志物发现：挑战与展望
Dahham Alsoud,Séverine Vermeire,Bram Verstockt
Dahham Alsoud
The past decades witnessed a significant stride in deciphering the pathophysiology of inflammatory bowel disease, which further advanced drug development adding several new biologicals and small molecules to the arsenal of available therapi...
Simvastatin ameliorates oxidative stress levels in HepG2 cells and hyperlipidemic rats [0.03%]
辛伐他汀改善HepG2细胞和高脂血症大鼠的氧化应激水平
Kanika Verma,Shikha Makwana,Sarvesh Paliwal et al.
Kanika Verma et al.
Simvastatin is an established anti-hyperlipidemic drug and few studies have indicated its role in the mitigation of oxidative stress. However, a systematic study considering molecular binding/interaction of simvastatin with anti-oxidant enz...