Myrtenal mitigates streptozotocin-induced spatial memory deficit via improving oxido inflammatory, cholinergic and neurotransmitter functions in mice [0.03%]
薄荷脑通过改善氧化炎症、胆碱能和神经递质功能来缓解链佐星致小鼠空间记忆障碍
Isaac Oluwatobi Akefe,Victoria Aderonke Adegoke,Ibrahim Yusuf Lamidi et al.
Isaac Oluwatobi Akefe et al.
The occurrence of chronic neurodegenerative disorders is on the rise, but with no effective treatment due to the paucity of information on the pathological mechanism underlying these disorders. Thus, this study investigated the role of oral...
Prolyl hydroxylase inhibitor desidustat improves anemia in erythropoietin hyporesponsive state [0.03%]
脯氨酰羟化酶抑制剂德斯奴司他改善促红细胞生成素低反应状态贫血疗效研究
Amit A Joharapurkar,Vishal J Patel,Samadhan G Kshirsagar et al.
Amit A Joharapurkar et al.
Many anemic chronic kidney disease (CKD) patients are refractory to erythropoietin (EPO) effects due to inflammation, deranged iron utilization, and generation of EPO antibodies. This work assessed the effect of desidustat, an inhibitor of ...
Positioning biologics in the treatment of IBD: A practical guide - Which mechanism of action for whom? [0.03%]
生物制剂在IBD治疗中的定位：一种实用指南-什么样的作用机制适用于谁？
Pascal Juillerat,Maude Martinho Grueber,Roseline Ruetsch et al.
Pascal Juillerat et al.
The number of available biological therapies have doubled over the last 10 years and the arrival of novel molecules (interleukin 23p19 inhibitors) is ongoing alongside the development of small molecules. As a result of this vast landscape o...
Galantamine tethered hydrogel as a novel therapeutic target for streptozotocin-induced Alzheimer's disease in Wistar rats [0.03%]
新型加兰他敏凝胶作为治疗威斯特大鼠链佐星诱导的阿尔茨海默病的方法研究
Manickam Rajkumar,Murugesan Sakthivel,Kottaisamy Senthilkumar et al.
Manickam Rajkumar et al.
Amyloid-β (Aβ) plaque formation, neuronal cell death, and cognitive impairment are the unique symptoms of Alzheimer's disease (AD). No single step remedy is available to treat AD, so the present study aimed to improve the drugability and ...
The safe use of inflammatory bowel disease therapies during the COVID-19 pandemic [0.03%]
新冠肺炎大流行期间炎症性肠病治疗的安全使用
Chethana Kamath,Erica J Brenner
Chethana Kamath
Background: Patients with inflammatory bowel disease (IBD) often require the use of immunosuppressant medications that increase infection risk, leading to concerns over the safe use of IBD medications during the Coronavir...
Pharmacodynamic evaluation of the XOR inhibitor WN1703 in a model of chronic hyperuricemia in rats induced by yeast extract combined with potassium oxonate [0.03%]
WN1703的药理学评价及其在酵母提取物联合草酸钾诱导的大鼠慢性高尿酸血症模型中的作用机制研究
Yuanyuan Li,Xinying Zhu,Fuyao Liu et al.
Yuanyuan Li et al.
Hyperuricemia is a common disease caused by a disorder of purine metabolism, which often causes hyperlipidemia and other metabolic diseases. WN1703 was demonstrated to be an effective xanthine oxidoreductase (XOR) inhibitor in our previous ...
Simon Pitchford,Isabella Zanella
Simon Pitchford
Ileal and colonic Crohn's disease: Does location makes a difference in therapy efficacy? [0.03%]
肠和回肠克罗恩病：位置对治疗效果有影响吗？
Raja Atreya,Christian Bojarski,Anja A Kühl et al.
Raja Atreya et al.
Within the IBD entity of Crohn's disease, there is currently no differentiation between ileal and colonic manifestation for recruitment of patients in clinical trials, well-powered analysis of study results or therapeutic decisions in daily...
Regulation of bFGF-induced effects on rat aortic smooth muscle cells by β3-adrenergic receptors [0.03%]
β3-肾上腺素受体对bFGF作用于大鼠主动脉平滑肌细胞的调节作用
Yingzi Chang,Lei Alena Dagat,Aisha Yusuf et al.
Yingzi Chang et al.
Background: Basic fibroblast growth factor (bFGF)-mediated vascular smooth muscle cell (VSMC) proliferation and migration play an important role in vascular injury-induced neointima formation and subsequent vascular reste...
Ted A Spiewak,Anish Patel
Ted A Spiewak
Inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD), are remitting and relapsing disorders of the gastrointestinal tract, highlighted by the dysregulation of pro- and anti-inflammatory mediators, which...