Characterization of a novel positive allosteric modulator of the α1A-Adrenergic receptor [0.03%]
α1A-肾上腺素能受体的新型正协同调节剂的特征描述
Robert S Papay,Jonathan D Macdonald,Shaun R Stauffer et al.
Robert S Papay et al.
α1-Adrenergic Receptors (ARs) are G-protein Coupled Receptors (GPCRs) that regulate the sympathetic nervous system via the binding and activation of norepinephrine (NE) and epinephrine (Epi). α1-ARs control various aspects of neurotransmi...
Sara Occhineri,Tommaso Matucci,Laura Rindi et al.
Sara Occhineri et al.
Coronavirus disease (COVID-19) pandemic determined a 10 years-set back in tuberculosis (TB) control programs. Recent advances in available therapies may help recover the time lost. While Linezolid (LZD) and Bedaquiline (BDQ), previously Gro...
Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms [0.03%]
配体可以不同时间和方式调节G蛋白偶联受体与14-3-3同工型的相互作用
Haifeng Eishingdrelo,Xiaofa Qin,Luwa Yuan et al.
Haifeng Eishingdrelo et al.
GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number of diverse protei...
Metabolic and clinical effect of alpha-lipoic acid administration in schizophrenic subjects stabilized with atypical antipsychotics: A 12-week, open-label, uncontrolled study [0.03%]
辅酶Q10联合α-硫辛酸对使用非典型抗精神病药物的稳定期精神分裂症患者的代谢及临床疗效：一项12周、开放性研究
Fiammetta Iannuzzo,Gianpaolo Antonio Basile,Domenica Campolo et al.
Fiammetta Iannuzzo et al.
Background: Many of the atypical antipsychotics induce metabolic side effects, limiting their use in clinical practice. Alpha-lipoic acid (ALA) was proposed as a new approach in schizophrenia to improve metabolic effects ...
Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism [0.03%]
雷帕霉素靶点抑制剂通过Akt/ALK5/Smad4信号诱导肾癌细胞中 Jagged-1 表达
David Danielpour,Sarah Corum,Patrick Leahy et al.
David Danielpour et al.
The mammalian target of rapamycin (mTOR) plays an important role in the aggressiveness and therapeutic resistance of many cancers. Targeting mTOR continues to be under clinical investigation for cancer therapy. Despite the notable clinical ...
Amelioration of experimentally induced inflammatory arthritis by intra-articular injection of visnagin [0.03%]
实验性注射补骨脂素改善炎性关节病
Sowmyasree Gurram,Pratibha Anchi,Biswajit Panda et al.
Sowmyasree Gurram et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia, cartilage destruction and bone erosion. Visnagin (VIS) is a proven anti-inflammatory agent and in t...
Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin [0.03%]
灵芝菌核水提取物预防环境毒物微囊藻毒素引起的肝脏病理变化
Pir Mohammad Ishfaq,Shivani Mishra,Anjali Mishra et al.
Pir Mohammad Ishfaq et al.
Environmental toxicants like microcystins are known to adversely impact liver physiology and lead to the increased risk for abnormal liver function and even liver carcinoma. Chaga mushroom (Inonotus obliquus) is reported for various propert...
Comparative study of rivastigmine and galantamine on the transgenic Drosophila model of Alzheimer's disease [0.03%]
在阿尔茨海默病转基因果蝇模型中比较石杉碱甲和加兰他敏的研究
Yasir Hasan Siddique,Falaq Naz,Rahul et al.
Yasir Hasan Siddique et al.
Alzheimer's Disease (AD) is characterized as a progressive neurodegenerative disease most commonly associated with memory deficits and cognitive decline. The formation of amyloid plaques and neurofibrillary tangles are important pathologica...
Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents [0.03%]
吲哚：一种有潜力的抗结核药物发现和发展的结构骨架分子
Nilesh Gajanan Bajad,Sudhir Kumar Singh,Sushil Kumar Singh et al.
Nilesh Gajanan Bajad et al.
Indole-containing small molecules have been reported to have diverse pharmacological activities. The aromatic heterocyclic scaffold, which resembles various protein structures, has received attention from organic and medicinal chemists. Exp...
Promising effects of emoxypine and its succinate derivative in the management of various diseases-with insights on recent patent applications [0.03%]
艾地苯及其苯磺酸衍生物在各种疾病管理中的前景及近期专利申请的见解
Dhruv Sanjay Gupta,Siddhi Bagwe Parab,Ginpreet Kaur
Dhruv Sanjay Gupta
Emoxypine and its succinate derivative share a common hydroxypridine structure, which is similar to pyridoxine. These compounds have been utilized therapeutically and industrially, owing to the wide range of properties offered. This include...