Modulatory role of miRNAs in thyroid and breast cancer progression and insights into their therapeutic manipulation [0.03%]
miRNA在甲状腺癌和乳腺癌进展中的调节作用及其治疗操作的见解
Rubai Ahmed,Sovan Samanta,Jhimli Banerjee et al.
Rubai Ahmed et al.
Over the past few decades, thyroid cancer has become one of the most common types of endocrine cancer, contributing to an increase in prevalence. In the year 2020, there were 586,202 newly diagnosed cases of thyroid cancer around the world....
Regulatory role of miRNAs in Wnt signaling pathway linked with cardiovascular diseases [0.03%]
miRNA在与心血管疾病相关Wnt信号通路中的调节作用
Jiban Kumar Behera,Manojit Bhattacharya,Pabitra Mishra et al.
Jiban Kumar Behera et al.
MicroRNAs (miRNAs) are discovered in science about 23 years ago. These are short, a series of non-coding, single-stranded and evolutionary conserved RNA molecules found in eukaryotic cells. It involved post-transcriptional fine-tune protein...
Shivani Desai,Juilee Jagtap,Shivani Sainani et al.
Shivani Desai et al.
The significance of mesenchymal stem cells (MSCs) for tissue repair and regeneration is widely recognized. The pleiotropic nature of MSCs is demonstrated by their potential for proliferation and differentiation, and paracrine secretions, th...
Characterization of a novel positive allosteric modulator of the α1A-Adrenergic receptor [0.03%]
α1A-肾上腺素能受体的新型正协同调节剂的特征描述
Robert S Papay,Jonathan D Macdonald,Shaun R Stauffer et al.
Robert S Papay et al.
α1-Adrenergic Receptors (ARs) are G-protein Coupled Receptors (GPCRs) that regulate the sympathetic nervous system via the binding and activation of norepinephrine (NE) and epinephrine (Epi). α1-ARs control various aspects of neurotransmi...
Sara Occhineri,Tommaso Matucci,Laura Rindi et al.
Sara Occhineri et al.
Coronavirus disease (COVID-19) pandemic determined a 10 years-set back in tuberculosis (TB) control programs. Recent advances in available therapies may help recover the time lost. While Linezolid (LZD) and Bedaquiline (BDQ), previously Gro...
Ligands can differentially and temporally modulate GPCR interaction with 14-3-3 isoforms [0.03%]
配体可以不同时间和方式调节G蛋白偶联受体与14-3-3同工型的相互作用
Haifeng Eishingdrelo,Xiaofa Qin,Luwa Yuan et al.
Haifeng Eishingdrelo et al.
GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number of diverse protei...
Metabolic and clinical effect of alpha-lipoic acid administration in schizophrenic subjects stabilized with atypical antipsychotics: A 12-week, open-label, uncontrolled study [0.03%]
辅酶Q10联合α-硫辛酸对使用非典型抗精神病药物的稳定期精神分裂症患者的代谢及临床疗效：一项12周、开放性研究
Fiammetta Iannuzzo,Gianpaolo Antonio Basile,Domenica Campolo et al.
Fiammetta Iannuzzo et al.
Background: Many of the atypical antipsychotics induce metabolic side effects, limiting their use in clinical practice. Alpha-lipoic acid (ALA) was proposed as a new approach in schizophrenia to improve metabolic effects ...
Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism [0.03%]
雷帕霉素靶点抑制剂通过Akt/ALK5/Smad4信号诱导肾癌细胞中 Jagged-1 表达
David Danielpour,Sarah Corum,Patrick Leahy et al.
David Danielpour et al.
The mammalian target of rapamycin (mTOR) plays an important role in the aggressiveness and therapeutic resistance of many cancers. Targeting mTOR continues to be under clinical investigation for cancer therapy. Despite the notable clinical ...
Amelioration of experimentally induced inflammatory arthritis by intra-articular injection of visnagin [0.03%]
实验性注射补骨脂素改善炎性关节病
Sowmyasree Gurram,Pratibha Anchi,Biswajit Panda et al.
Sowmyasree Gurram et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia, cartilage destruction and bone erosion. Visnagin (VIS) is a proven anti-inflammatory agent and in t...
Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin [0.03%]
灵芝菌核水提取物预防环境毒物微囊藻毒素引起的肝脏病理变化
Pir Mohammad Ishfaq,Shivani Mishra,Anjali Mishra et al.
Pir Mohammad Ishfaq et al.
Environmental toxicants like microcystins are known to adversely impact liver physiology and lead to the increased risk for abnormal liver function and even liver carcinoma. Chaga mushroom (Inonotus obliquus) is reported for various propert...