Neuroprotective effect of silymarin against 3-Nitropropionic acid-induced neurotoxicity in rats [0.03%]
奶蓟素对3-硝基丙酸诱导的大鼠神经毒性具有保护作用
Priyanka Chandolia,Vikrant Rahi,Puneet Kumar
Priyanka Chandolia
(HD) Huntington's disease is a severe hereditary catastrophic neurological disease with an autosomal dominant heritable changes manifested by cognitive, behavioural, and motor progression deficits, resulting in death. Several mechanisms are...
Anti-emetic effects of thalidomide: Evidence, mechanism of action, and future directions [0.03%]
反应停的抗呕吐效果：证据、作用机制及未来方向
Paul L R Andrews,Robin S B Williams,Gareth J Sanger
Paul L R Andrews
The rationale for using thalidomide (THD) as a treatment for nausea and vomiting during pregnancy in the late 1950s appears to have been based on its sedative or hypnotic properties. In contrast to contemporaneous studies on the anti-emetic...
Joana Torres,Ryan C Ungaro
Joana Torres
Blood pressure-lowering and cardiovascular effects of plumbagin in rats: An insight into the underlying mechanisms [0.03%]
紫草宁对大鼠的降血压和心血管效应及其潜在机制的研究
Maira Ahmad,Taseer Ahmad,Hafiz Muhammad Irfan et al.
Maira Ahmad et al.
Background: Plumbagin, a natural phenolic compound is investigated for response against blood pressure and vascular reactivity. Methodology: ...
Down regulation of fatty acid synthase via inhibition of PI3K/AKT/mTOR in ovarian cancer cell line by novel organoselenium pseudopeptide [0.03%]
新型有机硒伪肽通过抑制卵巢癌细胞系中的PI3K / AKT / mTOR下调脂肪酸合酶
Abeer M El-Saudi,Miram A Altouhamy,Saad Shaaban et al.
Abeer M El-Saudi et al.
Ovarian cancer (OC) is the 7th most common cancer in women world-wide and the 3rd most common female cancer. For the treatment of OC, there is no successful therapeutic. The medications that are currently available have significant side eff...
Erythropoietin administration exerted neuroprotective effects against cardiac ischemia/reperfusion injury [0.03%]
促红细胞生成素的给予对心脏缺血/再灌注损伤具有神经保护作用
Titikorn Chunchai,Nattayaporn Apaijai,Juthipong Benjanuwattra et al.
Titikorn Chunchai et al.
Acute myocardial infarction (AMI) leads to cardiac dysfunction and also causes brain dysfunction and pathology. The neuroprotective effects of erythropoietin (EPO), the hormone controlling the production of red blood cells, have been shown ...
Examination of central nervous system by functional observation battery after massive intravenous infusion of carbon monoxide-bound and oxygen-bound hemoglobin vesicles in rats [0.03%]
大鼠大量静脉输注一氧化碳结合型及氧气结合型血红蛋白囊泡后，经功能观测电池检测中枢神经系统变化的研究
Hiromi Sakai,Shunichi Yasuda,Chie Okuda et al.
Hiromi Sakai et al.
Carbon monoxide (CO) is known as a toxic gas inducing "CO poisoning", which acutely affects the central nervous system (CNS) and which persistently affects brain functions depending on the exposure time and CO concentration. By contrast, in...
miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hypoxia [0.03%]
用于调控缺氧诱导的血脑屏障通透性的microRNA纳米载体系统
Esteban G Figueroa,Aitor Caballero-Román,Josep R Ticó et al.
Esteban G Figueroa et al.
Central nervous system (CNS)-related diseases are difficult to treat as most therapeutic agents they cannot reach the brain tissue, mainly due to the blood-brain barrier (BBB), arguably the tightest barrier between the human body and cerebr...
Cellular and molecular mechanisms, genetic predisposition and treatment of diabetes-induced cardiomyopathy [0.03%]
糖尿病引起的心肌病的细胞和分子机制、遗传易感性和治疗手段
Urvashi Sharma,Manodeep Chakraborty,Devid Chutia et al.
Urvashi Sharma et al.
Diabetes mellitus is a common disease affecting millions of people worldwide. This disease is not limited to metabolic disorders but also affects several vital organs in the body and can lead to major complications. People with diabetes mel...
Structural analysis of cannabinoids against EGFR-TK leads a novel target against EGFR-driven cell lines [0.03%]
针对EGFR激酶的 cannabinoid 结构分析导致了针对由EGFR驱动的细胞系的新靶点出现
Thomanai Lamtha,Lueacha Tabtimmai,Napat Songtawee et al.
Thomanai Lamtha et al.
Epidermal growth factor receptor (EGFR) is a member of the ErbB family of proteins and are involved in downstream signal transduction, plays prominent roles in cell growth regulation, proliferation, and the differentiation of many cell type...