Adenosine receptor ligation tips the uveitogenic Th1 and Th17 balance towards the latter in experimental autoimmune uveitis-induced mouse [0.03%]
腺苷受体激活在实验性自身免疫性葡萄膜炎小鼠模型中将致病的Th1和Th17细胞的平衡向后者倾斜
Deming Sun,Minhee Ko,Hui Shao et al.
Deming Sun et al.
Various pathological conditions are accompanied by release of adenosine triphosphate (ATP) from the intracellular to the extracellular compartment, where it degrades into adenosine and modulates immune responses. Previous studies concluded ...
Immune and cellular damage biomarkers to predict COVID-19 mortality in hospitalized patients [0.03%]
免疫和细胞损伤生物标志物可预测住院患者中COVID-19的死亡率
Carlo Lombardi,Elena Roca,Barbara Bigni et al.
Carlo Lombardi et al.
Early prediction of COVID-19 in-hospital mortality relies usually on patients' preexisting comorbidities and is rarely reproducible in independent cohorts. We wanted to compare the role of routinely measured biomarkers of immunity, inflamma...
Tissue macrophages and interferon-gamma signalling control blood-stage Plasmodium chabaudi infections derived from mosquito-transmitted parasites [0.03%]
组织巨噬细胞和干扰素-伽玛信号控制蚊媒寄生虫来源的血源期Plasmodium chabaudi感染
Katrien Deroost,Christopher Alder,Caroline Hosking et al.
Katrien Deroost et al.
Natural infection with Plasmodium parasites, the causative agents of malaria, occurs via mosquito vectors. However, most of our knowledge of the immune response to the blood stages of Plasmodium is from infections initiated by injection of ...
Neuro-immune communication in C. elegans defense against pathogen infection [0.03%]
神经免疫在秀丽隐杆线虫防御病原体感染中的作用通讯
Phillip Wibisono,Jingru Sun
Phillip Wibisono
The innate immune system is a complex collection of physical barriers and physiological defense responses to internal and external environmental assaults. Recent studies in the model organism Caenorhabditis elegans have highlighted how the ...
Myeloid cell responsiveness to interferon-gamma is sufficient for initial resistance to Listeria monocytogenes [0.03%]
单核细胞对干扰素-γ的反应性足以抵抗李斯特菌初始感染
Emily M Eshleman,Nikki Bortell,Daniel S McDermott et al.
Emily M Eshleman et al.
The type II interferon (IFNγ) promotes resistance to intracellular pathogens. Most immune and somatic cells also express the IFNγ receptor (IFNGR) and respond to IFNγ. While myeloid cell have been implicated as important targets of IFNγ...
Jose A Villadangos
Jose A Villadangos
Reduced A-to-I editing of endogenous Alu RNAs in lung after SARS-CoV-2 infection [0.03%]
新冠病毒感染后肺组织中内源Alu RNA的A到I编辑减少
Philip S Crooke rd,John T Tossberg,Krislyn P Porter et al.
Philip S Crooke rd et al.
Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced A-to-I editing of endogenous double-strande...
Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells [0.03%]
癌症蛋白磷酸酶2A抑制物(CIP2A)在Th17细胞中的蛋白质相互作用组学
Mohd Moin Khan,Tommi Välikangas,Meraj Hasan Khan et al.
Mohd Moin Khan et al.
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is involved in immune response, cancer progression, and Alzheimer's disease. However, an understanding of the mechanistic basis of its function in this wide spectrum of physiological and...