Inhibition of NK cell cytotoxicity by tubular epithelial cell expression of Clr-b and Clr-f [0.03%]
Clr-b和Clr-f在肾小管上皮细胞中的表达对NK细胞细胞毒性的抑制作用
Benjamin Fuhrmann,Jifu Jiang,Patrick Mcleod et al.
Benjamin Fuhrmann et al.
NK cells participate in ischemia reperfusion injury (IRI) and transplant rejection. Endogenous regulatory systems may exist to attenuate NK cell activation and cytotoxicity in IRI associated with kidney transplantation. A greater understand...
Cytokine levels in gingival tissues as an indicator to understand periodontal disease severity [0.03%]
龈组织细胞因子水平作为判断牙周病严重程度的指标
Pratebha Balu,Agiesh Kumar Balakrishna Pillai,Vignesh Mariappan et al.
Pratebha Balu et al.
Cytokines regulate periodontal pathogenesis and are relevant estimates of current disease activity. There is sparse information on status of cytokine protein levels in periodontal pocket (gingival) tissues. The current study analysed protei...
Lymphoblastoid cell lines do not recapitulate physiological circulating B cell subtypes [0.03%]
淋巴母细胞系不能再现生理循环B细胞亚型
Connie MacKinnon,Ryan McLean,Antonia L Pritchard
Connie MacKinnon
Lymphoblastoid cell lines (LCLs) are immortalised peripheral B lymphocytes, transformed via infection with Epstein Barr virus (EBV). The use of LCLs to study B cell function remains controversial and core markers to define physiological B c...
Bruno L Diaz,Christianne Bandeira-Melo
Bruno L Diaz
Prostaglandin (PG)D2 is produced and/or triggered by different parasites to modulate the course of the infection. These findings position PGD2 as a therapeutic target and suggest potential beneficial effects of repositioned drugs that targe...
Mitochondrial electron transport chain in macrophage reprogramming: Potential role in antibacterial immune response [0.03%]
线粒体呼吸链在巨噬细胞重编程中的作用及其在细菌感染免疫应答中的潜在功能研究
Manmohan Kumar,Shagun Sharma,Jai Kumar et al.
Manmohan Kumar et al.
Macrophages restrain microbial infection and reinstate tissue homeostasis. The mitochondria govern macrophage metabolism and serve as pivot in innate immunity, thus acting as immunometabolic regulon. Metabolic pathways produce electron flow...
An increase in regulatory T cells in peripheral blood correlates with an adverse prognosis for malignant melanoma patients - A study of T cells and natural killer cells [0.03%]
恶性黑色素瘤患者外周血调节性T细胞的升高与不良预后有关——T细胞和自然杀伤细胞的研究
Nanna Heldager Pedersen,Helene Bjerregaard Jeppesen,Gry Persson et al.
Nanna Heldager Pedersen et al.
Malignant melanoma is a highly immunogenic tumour, and the immune profile significantly influences cancer development and response to immunotherapy. The peripheral immune profile may identify high risk patients. The current study showed red...
Nanoparticles cellular uptake, trafficking, activation, toxicity and in vitro evaluation [0.03%]
纳米颗粒的细胞摄取、传输、激活、毒性和体外评价方法
Fernanda Toscano,Marbel Torres-Arias
Fernanda Toscano
Nanoparticles (NPs) physicochemical properties, such as size, shape, surface chemistry, charge, etc., play a critical role in biological systems interactions, which include NPs' cellular uptake, trafficking, activation, and toxicity. Althou...
The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review [0.03%]
鼠疫疫苗的有效性、安全性和免疫原性：系统文献回顾
Louise Hartley,Sydney Harold,Emma Hawe
Louise Hartley
Plague remains endemic in many parts of the world, and despite efforts, no preventative vaccine is available. We performed a systemic review of available randomised controlled trials (RCTs) of live, attenuated, or killed plague vaccines vs....
Functional role of the TGF-β signaling in the Drosophila immune response [0.03%]
转化生长因子-β信号在果蝇免疫反应中的功能作用
Ashley Bastin,Ioannis Eleftherianos
Ashley Bastin
TGF-β signaling pathways are present in diverse animal species, which indicates their evolutionary importance in modulating several conserved biological processes and maintaining host homeostasis by adjusting the activity of innate immune ...
An evidence-based debate on epigenetics and immunosenescence in COVID-19 [0.03%]
基于证据的关于表观遗传学和免疫衰老在COVID-19中的辩论
Claudio Napoli,Enrico Coscioni,Ugo Trama et al.
Claudio Napoli et al.
Immunosenescence contributes to the decline of immune function leading to a reduced ability to respond to severe coronavirus disease 2019 (COVID-19) in elderly patients. Clinical course of COVID-19 is widely heterogeneous and guided by the ...