Erin A Marshall,Nikita Telkar,Wan L Lam
Erin A Marshall
The importance of gut microbiome to cancer therapy and response cannot be overstated, however the contribution of the bacterial population to the local solid tumour ecosystem is often overlooked. Seminal studies of tumour-resident microbiom...
Plasmodium berghei Hsp90 contains a natural immunogenic I-Ab-restricted antigen common to rodent and human Plasmodium species [0.03%]
间日疟原虫HSP90含有一种天然免疫原表位，可被小鼠I-Ab限制并广泛存在于鼠和人类疟原虫中
Matthias H Enders,Ganchimeg Bayarsaikhan,Sonia Ghilas et al.
Matthias H Enders et al.
Thorough understanding of the role of CD4 T cells in immunity can be greatly assisted by the study of responses to defined specificities. This requires knowledge of Plasmodium-derived immunogenic epitopes, of which only a few have been iden...
Shared inflammatory and skin-specific gene signatures reveal common drivers of discoid lupus erythematosus in canines, humans and mice [0.03%]
共享的炎症和皮肤特异性基因特征揭示了犬、人类和小鼠盘状狼疮的共同驱动因素
Colton J Garelli,Neil B Wong,Cesar Piedra-Mora et al.
Colton J Garelli et al.
Autoimmune skin diseases are complex and are thought to arise from a combination of genetics and environmental exposures, which trigger an ongoing immune response against self-antigens. Companion animals including cats and dogs are known to...
Prime-boost with Chikungunya virus E2 envelope protein combined with Poly (I:C) induces specific humoral and cellular immune responses [0.03%]
夏克立昆雅病毒E2包膜蛋白联合Poly(I:C)的原种-加强免疫诱导特异性体液及细胞免疫应答
Marcelo Pires Amaral,Fernanda Caroline Coirada,Juliana de Souza Apostolico et al.
Marcelo Pires Amaral et al.
Chikungunya virus (CHIKV) is an arbovirus transmitted to humans mainly by the bite of infected Aedes aegypti and Aedes albopictus mosquitoes. CHIKV illness is characterized by fever and long-lasting arthritic symptoms, and in some cases it ...
Exposure to the gut microbiota from cigarette smoke-exposed mice exacerbates cigarette smoke extract-induced inflammation in zebrafish larvae [0.03%]
暴露于香烟烟雾暴露小鼠的肠道微生物群会加剧斑马鱼幼虫中香烟提取物诱导的炎症反应
Simone Morris,Kathryn Wright,Vamshikrishna Malyla et al.
Simone Morris et al.
Cigarette smoke (CS)-induced inflammation leads to a range of diseases including chronic obstructive pulmonary disease and cancer. The gut microbiota is a major modifying environmental factor that determine the severity of cigarette smoke-i...
Neurokinin receptors and their implications in various autoimmune diseases [0.03%]
神经激肽受体及其在自身免疫性疾病中的作用
Amrita Mishra,Girdhari Lal
Amrita Mishra
Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed throughout the nervous and immune systems. Neurokinin receptors in coordination with neurokinins playing an important role in many physiological processes, inclu...
Gamma-tocotrienol modifies methylation of HOXA10, IRF4 and RORα genes in CD4+ T-lymphocytes: Evidence from a syngeneic mouse model of breast cancer [0.03%]
γ-托考三烯醇对乳腺癌同种异系小鼠模型CD4+T淋巴细胞HOXA10、IRF4和RORα基因甲基化的改变作用
Ammu K Radhakrishnan,Jeya Seela Anandha Rao,Shonia Subramaniam et al.
Ammu K Radhakrishnan et al.
DNA methylation plays a crucial role in polarising naïve lymphocytes towards their various sub-populations to fight against many immune challenges including establishment of tumour. Gamma-tocotrienol (γT3) is a natural form of vitamin E, ...
Heterologous vaccine therapy associated with half course of Miltefosine promote activation of the proinflammatory response with control of splenic parasitism in a hamster model of visceral leishmaniasis [0.03%]
异基因疫苗疗法联合米替福新半程治疗可促进促炎反应并控制沙鼠内脏利什曼病模型的脾脏寄生虫感染
Lívia Mendes Carvalho,Francielle Carvalho Ferreira,Miriã Rodrigues Gusmão et al.
Lívia Mendes Carvalho et al.
Visceral leishmaniasis (VL) is a serious and neglected disease present worldwide. Chemotherapy using pentavalent antimony (SbV) is the most practical and inexpensive strategy available for the VL treatment today, however, it has high toxici...
Impact of the induction phase chemotherapy on cytokines and oxidative markers in peripheral and bone marrow plasma of children with acute lymphocytic leukemia [0.03%]
诱导化疗对急性淋巴细胞白血病患儿外周及骨髓血浆细胞因子及氧化标志物的影响
G E Broto,P R B Silva,F C Trigo et al.
G E Broto et al.
B-cell acute lymphocytic leukemia (B-ALL) is the main neoplasia affecting children worldwide, in which cytotoxic chemotherapy remains the main treatment modality. In this study, we analyzed the profile of inflammatory markers concerning oxi...
Short chain fatty acids (SCFAs) improves TNBS-induced colitis in zebrafish [0.03%]
短链脂肪酸可改善斑马鱼中的TNBS诱导性结肠炎
Camila Morales Fénero,Mariana Abrantes Amaral,Izabella Karina Xavier et al.
Camila Morales Fénero et al.
The short-chain fatty acids (SCFAs) are metabolites originated from the fermentation of dietary fibers and amino acids produced by the bacteria of the intestinal microbiota. The most abundant SCFAs, acetate, propionate, and butyrate, have b...