Impact of IgG1 N-glycosylation on their interaction with Fc gamma receptors [0.03%]
IgG1的N-糖基化对其与Fcγ受体相互作用的影响
Florian Cambay,Céline Raymond,Denis Brochu et al.
Florian Cambay et al.
The effector functions of the IgGs are modulated by the N-glycosylation of their Fc region. Particularly, the absence of core fucosylation is known to increase the affinity of IgG1s for the Fcγ receptor IIIa expressed by immune cells, in t...
Genetic changes of Plasmodium vivax tempers host tissue-specific responses in Anopheles stephensi [0.03%]
恶性疟原虫遗传改变使按蚊对宿主组织特异性反应缓和
Seena Kumari,Charu Chauhan,Sanjay Tevatiya et al.
Seena Kumari et al.
Recently, we showed how an early restriction of gut flora proliferation by Plasmodium vivax favors immune-suppression and Plasmodium survival in the gut lumen (Sharma et al., 2020). Here, we asked post gut invasion how P. vivax interacts wi...
Sushanta Chhatar,Girdhari Lal
Sushanta Chhatar
Neuroimmune communication plays a crucial role in maintaining homeostasis and promptly responding to any foreign insults. Sympathetic nerve fibres are innervated into all the lymphoid organs (bone marrow, thymus, spleen, and lymph nodes) an...
Jadesola Jadé Temitope Olayinka,Jillian M Richmond
Jadesola Jadé Temitope Olayinka
Alopecia areata (AA) is an autoimmune disorder resulting in hair loss. It has numerous variants or patterns, including diffuse type, patchy type, AA totalis, AA universalis, and more. In this graphical review, we provide an overview of AA i...
Optimization of stimulation and staining conditions for intracellular cytokine staining (ICS) for determination of cytokine-producing T cells and monocytes [0.03%]
细胞内细胞因子染色（ICS）以确定产生细胞因子的T细胞和单核细胞的刺激和染色条件的优化
Wilson Mandala,Visopo Harawa,Alinane Munyenyembe et al.
Wilson Mandala et al.
Cell-mediated responses to immunological stimuli are often localised in inflammatory sites and involve a number of cell types. These responses can be functionally characterised at the single-cell level on the basis of the types of cytokines...
Tumor-infiltrating T-regulatory cells adapt to altered metabolism to promote tumor-immune escape [0.03%]
肿瘤浸润性调节t细胞适应代谢改变以促进肿瘤免疫逃逸
Tania Sarkar,Subhanki Dhar,Gaurisankar Sa
Tania Sarkar
Tumor mass and its microenvironment alter host immune system in various ways to promote tumor growth. One of the modifications is evasion of immune surveillance by augmenting the number of Tregs in tumor vicinity. Elevated levels of Tregs a...
Physiological substrates and ontogeny-specific expression of the ubiquitin ligases MARCH1 and MARCH8 [0.03%]
MARCH1和MARCH8泛素连接酶的生理基质与发育特异性表达
Patrick Schriek,Haiyin Liu,Alan C Ching et al.
Patrick Schriek et al.
MARCH1 and MARCH8 are ubiquitin ligases that control the expression and trafficking of critical immunoreceptors. Understanding of their function is hampered by three major knowledge gaps: (i) it is unclear which cell types utilize these lig...
Jane Zveiter Moraes,Bárbara Hamaguchi,Camila Braggion et al.
Jane Zveiter Moraes et al.
The isolation of single monoclonal antibodies (mAbs) against a given antigen was only possible with the introduction of the hybridoma technology, which is based on the fusion of specific B lymphocytes with myeloma cells. Since then, several...
STAT6 signaling pathway controls germinal center responses promoted after antigen targeting to conventional type 2 dendritic cells [0.03%]
STAT6信号通路控制将抗原靶向到常规II型树突状细胞后促进的生发中心反应
Fernando Bandeira Sulczewski,Larissa Alves Martino,Bianca da Silva Almeida et al.
Fernando Bandeira Sulczewski et al.
Conventional dendritic cells (cDCs) are antigen-presenting cells specialized in naïve T cell priming. Mice splenic cDCs are classified as cDC1s and cDC2s, and their main functions have been elucidated in the last decade. While cDC1s are sp...
Extracellular vesicles derived from head and neck squamous cells carcinoma inhibit NLRP3 inflammasomes [0.03%]
来自头颈部鳞状细胞癌的细胞外囊泡可抑制NLRP3炎性小体
Luiza Zainotti Miguel Fahur Bottino,Dorival Mendes Rodrigues-Junior,Ingrid Sancho de Farias et al.
Luiza Zainotti Miguel Fahur Bottino et al.
The content of tumor-derived extracellular vesicles (EVs) can regulate the tumor microenvironment and functionally acts in favor of cancer aggressiveness. To better elucidate the role of EVs in the interplay between immune system and tumor ...