Clinically approved combination immunotherapy: Current status, limitations, and future perspective [0.03%]
临床批准的免疫联合治疗：现状、局限性及未来展望
Ligong Lu,Meixiao Zhan,Xian-Yang Li et al.
Ligong Lu et al.
Immune-checkpoint inhibitor-based combination immunotherapy has become a first-line treatment for several major types of cancer including hepatocellular carcinoma (HCC), renal cell carcinoma, lung cancer, cervical cancer, and gastric cancer...
Sphingosine-1-phosphate receptors 2 and 3 reprogram resting human macrophages into M1 phenotype following mycobacteria infection [0.03%]
鞘氨醇-1-磷酸受体2和3在分枝杆菌感染后可将静息人单核巨噬细胞重编程为M1表型
Mohd Arish,Farha Naz
Mohd Arish
Mycobacteria tuberculosis (M.tb) the causative agent for tuberculosis has been accredited for a high rate of morbidity and mortality worldwide. The rise in MDR and XDR cases has further created new obstacles in achieving the "End TB Strateg...
DDX3X structural analysis: Implications in the pharmacology and innate immunity [0.03%]
DDX3X结构分析：其在药理学和先天免疫中的意义
Luigi De Colibus,Melissa Stunnenberg,Teunis B H Geijtenbeek
Luigi De Colibus
The human DEAD-Box Helicase 3 X-Linked (DDX3X) is an ATP-dependent RNA helicase involved in virtually every step of RNA metabolism, ranging from transcription regulation in the nucleus to translation initiation and stress granule (SG) forma...
Homotypic and heterotypic in cis associations of MHC class I molecules at the cell surface [0.03%]
主要组织相容性复合体Ⅰ类分子在细胞表面顺式同型和异型关联
Fernando M Ruggiero,Sebastian Springer
Fernando M Ruggiero
Through the presentation of peptide antigens to cytotoxic T lymphocytes, major histocompatibility complex (MHC) class I molecules mediate the adaptive immune response against tumors and viruses. Additional non-immunological functions includ...
Different wild type strains of zebrafish show divergent susceptibility to TNBS-induced intestinal inflammation displaying distinct immune cell profiles [0.03%]
不同野生型斑马鱼品系中TNBS诱导的肠道炎症易感性的差异及其免疫细胞特征的不同
Barbara Nunes Padovani,Mariana Abrantes do Amaral,Camila Morales Fénero et al.
Barbara Nunes Padovani et al.
Little is known about the diversity in immune profile of the different wild type strains of zebrafish (Danio rerio), despite its growing popularity as an animal model to study human diseases and drug testing. In the case of data resulting f...
All trans retinoic acid as a host-directed immunotherapy for tuberculosis [0.03%]
全反式维甲酸作为针对宿主的结核病免疫疗法
Ahmad Z Bahlool,Conor Grant,Sally-Ann Cryan et al.
Ahmad Z Bahlool et al.
Tuberculosis (TB) is the top bacterial infectious disease killer and one of the top ten causes of death worldwide. The emergence of strains of multiple drug-resistant tuberculosis (MDR-TB) has pushed our available stock of anti-TB agents to...
Salix Boulet,Laure Le Corre,Livia Odagiu et al.
Salix Boulet et al.
The myeloid cellular compartment comprises monocytes, dendritic cells (DCs), macrophages and granulocytes. As diverse as this group of cells may be, they are all an important part of the innate immune system and are therefore linked by the ...
The emerging roles of eosinophils: Implications for the targeted treatment of eosinophilic-associated inflammatory conditions [0.03%]
嗜酸性粒细胞的新兴作用：针对嗜酸性相关炎症疾病的靶向治疗的意义
Carlo Lombardi,Alvise Berti,Marcello Cottini
Carlo Lombardi
Eosinophils have multiple relevant biological functions, including the maintenance of homeostasis, host defense against infectious agents, innate immunity activities, immune regulation through Th1/Th2 balance, anti-inflammatory, and anti-tu...
Loss of thymic function promotes EAE relapse in anti-CD52-treated mice [0.03%]
抗CD52治疗小鼠的胸腺功能减退可诱发自身免疫性脑脊髓炎复发
Adeolu O Adegoke,Jiaxin Lin,Colin C Anderson
Adeolu O Adegoke
Anti-CD52 treatment creates a long-lasting CD4 T cell lymphopenia and reduces multiple sclerosis (MS) relapses in humans. In contrast, anti-CD52 therapy at disease onset more fully suppresses experimental autoimmune encephalomyelitis (EAE) ...
Silvia A Fuertes Marraco,Daniel Alpern,Sébastien Lofek et al.
Silvia A Fuertes Marraco et al.
CD8 T cells have multiple functional properties that mediate acute phase and long-term immune protection. Several effector and memory CD8 T cell subsets have been described with diverse functionalities and marker profiles. In contrast to th...