T cell immunity is key to the pandemic endgame: How to measure and monitor it [0.03%]
T细胞免疫是疫情终结的关键：如何衡量和监测它
Megan Schwarz,Slim Mzoughi,Daniel Lozano-Ojalvo et al.
Megan Schwarz et al.
As vaccine deployment improves the healthcare emergency status caused by the SARS-CoV-2 pandemic, we need reliable tools to evaluate the duration of protective immunity at a global scale. Seminal studies have demonstrated that while neutral...
Mechanobiology of immune cells: Messengers, receivers and followers in leishmaniasis aiding synthetic devices [0.03%]
免疫细胞的机械生物学：利什曼病中传递信息、接受信息和跟随的合成装置辅助分子机制
Shweta Khandibharad,Prajakta Nimsarkar,Shailza Singh
Shweta Khandibharad
Cytokines are influential molecules which can direct cells behavior. In this review, cytokines are referred as messengers, immune cells which respond to cytokine stimulus are referred as receivers and the immune cells which gets modulated d...
Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes [0.03%]
Dach1转录因子调节外周淋巴结地址素的表达及淋巴细胞在淋巴结中的迁移 Trafficking
Arisa Shintani,Shoko Fukai,Reika Nobusawa et al.
Arisa Shintani et al.
Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lym...
Rapid peptide exchange on MHC class I by small molecules elucidates dynamics of bound peptide [0.03%]
小分子快速改变MHC I类蛋白上的肽结合能阐明结合肽的动力学性质
Andries Hadeler,Ankur Saikia,Martin Zacharias et al.
Andries Hadeler et al.
Complexes of peptides with recombinant major histocompatibility complex class I molecules (rpMHCs) are an important tool for T cell detection, isolation, and activation in cancer immunotherapy. The rapid preparation of rpMHCs is aided by pe...
NMR spectroscopy spotlighting immunogenicity induced by COVID-19 vaccination to mitigate future health concerns [0.03%]
核磁共振光谱聚焦由COVID-19疫苗引起的免疫原性以减轻未来的健康问题
Sher Ali,Štěpánka Nedvědová,Gul Badshah et al.
Sher Ali et al.
In this review, the disease and immunogenicity affected by COVID-19 vaccination at the metabolic level are described considering the use of nuclear magnetic resonance (NMR) spectroscopy for the analysis of different biological samples. Cons...
Salmonella-induced immune response reduces recurrence and tumor dissemination in preclinical melanoma model [0.03%]
沙门氏菌诱导的免疫反应可减少黑色素瘤模型中的复发和肿瘤扩散
Amy Mónaco,María C Plata,Sofía Chilibroste et al.
Amy Mónaco et al.
Localized melanoma is easy to remove by surgery, resulting in a high five-year relative survival rate. However, when disseminated the disease management is challenging. The use of immunotherapies, such as anti-checkpoint monoclonal antibodi...
Alba Grifoni,Alessandro Sette
Alba Grifoni
It is critically important to understand how the adaptive immune response, elicited by vaccination or infection, recognizes SARS-CoV-2. This is especially true when considering the challenges to the immune response posed by variant evolutio...
Luis Enjuanes,Isabel Sola,Sonia Zúñiga et al.
Luis Enjuanes et al.
Coronaviruses (CoVs) have the largest genome among RNA viruses and store large amounts of information without genome integration as they replicate in the cell cytoplasm. The replication of the virus is a continuous process, whereas the tran...
Alicante-Winter Immunology Symposium in Health (A-Wish) and the Boulle-SEI awards: A collaboration between the Spanish Society for immunology, the University of Alicante and the Jean Boulle Group to honor the Balmis Expedition [0.03%]
西班牙免疫学协会、阿利坎特大学和让布勒集团合作举办阿利坎特冬季健康免疫学研讨会（A-Wish）及Boulle-SEI奖，以纪念巴拉米斯远征队
Jordi Ochando,Carmen Camara,Leighton Durham et al.
Jordi Ochando et al.
Image 1. © 2022 Published by Elsevier B.V.
The antibody-binding Fc gamma receptor IIIa / CD16a is N-glycosylated with high occupancy at all five sites [0.03%]
抗体结合的Fcγ受体IIIa/CD16a在所有五个位点都具有高占有率的N-聚糖结构式
Elizabeth A Lampros,Paul G Kremer,Jesús S Aguilar Díaz de León et al.
Elizabeth A Lampros et al.
The antibody-binding Fc γ receptors (FcγRs) trigger life-saving immune responses and many therapeutic monoclonal antibodies require FcγR engagement for full effect. One proven strategy to improve the efficacy of antibody therapies is to ...