Acute to post-acute COVID-19 thromboinflammation persistence: Mechanisms and potential consequences [0.03%]
急性至后急性期新冠肺炎血栓性炎症持续存在：机制及潜在后果
Remy Martins-Gonçalves,Eugenio D Hottz,Patricia T Bozza
Remy Martins-Gonçalves
Concerns for the long-term effects of COVID-19 infection have grown due to frequently reported persisting symptoms that can affect multiple systems for longer than 4 weeks after initial infection, a condition known as long-COVID-19 or post-...
Battle royale: Immune response on biofilms - host-pathogen interactions [0.03%]
战斗 Royale：生物膜上的免疫反应-宿主病原体相互作用
Sandra Pamela Cangui-Panchi,Anahí Lizbeth Ñacato-Toapanta,Leonardo Joshué Enríquez-Martínez et al.
Sandra Pamela Cangui-Panchi et al.
The research interest of the scientific community in biofilm-forming microorganisms is growing due to the problems caused by their infections affecting humans and animals, mainly because of the difficulty of the host immune system in eradic...
Giovanni Monteleone,Federica Laudisi,Carmine Stolfi
Giovanni Monteleone
In physiological conditions, the human gut contains more immune cells than the rest of the body, but no overt tissue damage occurs, because several regulatory mechanisms control the activity of such cells thus preventing excessive and detri...
Novel insights in the clinical management of hyperimmune patients before and after transplantation [0.03%]
关于移植物前后的高免疫患者临床管理的新见解
Vincenzo Grimaldi,Martina Pagano,Giusi Moccia et al.
Vincenzo Grimaldi et al.
Despite improvements in anti-Human Leucocyte Antigens antibody detection, identification, and characterization offer a better in peri-operative management techniques, antibodies remain a serious cause of morbidity and mortality for patients...
Antibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stages [0.03%]
由血液阶段疟疾感染引起的抗体依赖性免疫反应有助于对红细胞前期的保护性免疫力贡献
Irene Tumwine-Downey,Katrien Deroost,Prisca Levy et al.
Irene Tumwine-Downey et al.
Advances in transcriptomics and proteomics have revealed that different life-cycle stages of the malaria parasite, Plasmodium, share antigens, thus allowing for the possibility of eliciting immunity to a parasite life-cycle stage that has n...
TLR ligand ligation switches adenosine receptor usage of BMDCs leading to augmented Th17 responses in experimental autoimmune uveitis [0.03%]
TLR配体结合转换BMDC的腺苷受体使用导致实验性自身免疫性前葡萄膜炎中的Th17反应增强
Deming Sun,Hui Shao,Henry J Kaplan
Deming Sun
The extracellular level of adenosine increases greatly during inflammation, which modulates immune responses. We have previously reported that adenosine enhances Th17 responses while it suppresses Th1 responses. This study examined whether ...
An adaptable in vitro cytokine release assay (CRA): Susceptibility to cytokine storm in COVID-19 as a model [0.03%]
一种可适应的体外细胞因子释放试验(CRA)：以COVID-19中的细胞因子风暴易感性为模型
Masih Alam,Rawshan Choudhury,Robert-Jan Lamers
Masih Alam
Translational in vitro models such as cytokine release assay (CRA) are essential to assess the susceptibility to cytokine storm or CRS in a non-interventional manner in a human in vitro laboratory setting. Such models are also helpful to un...
Adolfo García-Sastre
Adolfo García-Sastre
The rapid evolution of SARS-CoV-2 since its pandemic outbreak has underscored the need for improved SARS-CoV-2 vaccines that efficiently reduce not only hospitalizations and deaths, but also infections and transmission. This might be achiev...
Chemotherapy induces plasmatic antioxidant changes in pediatric patients with acute lymphoid leukemia B that correlate to disease prognosis [0.03%]
化疗可诱导急性B淋巴细胞白血病患儿产生抗氧状态变化并影响预后
Matheus Ricardo Garbim,Geise Ellen Broto,Fausto Celso Trigo et al.
Matheus Ricardo Garbim et al.
Pediatric acute lymphoid leukemias (ALL) is the most common childhood cancer, and cytotoxic chemotherapy remains the primary treatment option. Chemotherapic drugs act by oxidative stress generation, but their clinical meaning is poorly unde...
New insights into the tumour immune microenvironment of nasopharyngeal carcinoma [0.03%]
鼻咽癌肿瘤免疫微环境新探
Aisling Forder,Greg L Stewart,Nikita Telkar et al.
Aisling Forder et al.
Nasopharyngeal carcinoma (NPC) is unique among head and neck cancers for its strong causative association with Epstein Barr-Virus and high levels of immune infiltration that play a role in pathogenesis. As such, immunotherapy for the treatm...