Availability, accessibility and use of antivenom for snakebite envenomation in Africa with proposed strategies to overcome the limitations [0.03%]
非洲抗蛇毒血清的可用性、可及性和使用状况及其局限性的应对策略
Mahmood Muazu Dalhat,Julien Potet,Abdulaziz Mohammed et al.
Mahmood Muazu Dalhat et al.
Africa remains one of the regions with the highest incident and burden of snakebite. The goal of the World Health Organization to halve the global burden of snakebite by 2030 can only be achieved if sub-optimal access to antivenoms in the m...
A subfraction obtained from the venom of the tarantula Poecilotheria regalis contains inhibitor cystine knot peptides and induces relaxation of rat aorta by inhibiting L-type voltage-gated calcium channels [0.03%]
从大王琴鸟球蛛毒液中获得的亚组分包含胱氨酸 knot 肽并通过抑制L型电压门控钙通道诱导大鼠主动脉舒张
Luis Fernando Díaz-Peña,Torres-Ortiz Daniela,Manuel B Aguilar et al.
Luis Fernando Díaz-Peña et al.
Venoms from tarantulas contain low molecular weight vasodilatory compounds whose biological action is conceived as part of the envenomation strategy due to its propagative effects. However, some properties of venom-induced vasodilation do n...
Franklin Riet-Correa,Mizael Machado,Juan F Micheloud
Franklin Riet-Correa
This paper reviews toxic plants for livestock in South America. We included 219 plants in this review, considering only the plants that caused at least one demonstrated outbreak of poisoning. Plants reported as toxic in other regions and pr...
Evaluation of the properties of Bungarus caeruleus venom and checking the efficacy of antivenom used in Bangladesh for its bite treatment [0.03%]
评估Bungarus caeruleus毒液的性质并检测在孟加拉国用于其咬伤治疗的抗毒血清的有效性
Md Jahangir Alam,Md Mahmudul Hasan Maruf,Md Asif Iqbal et al.
Md Jahangir Alam et al.
As a disaster-prone country with unique geographical features, snake biting is a major public health concern in Bangladesh. The primary reasons of mortality from snakebite include late presentation to the hospital, low efficacy of antivenom...
Multifaceted community health education programs as powerful tools to mitigate snakebite-induced deaths, disabilities, and socioeconomic burden [0.03%]
多方面的社区健康教育项目作为减轻蛇咬引起的死亡、残疾和经济社会负担的强大工具
Sakthivel Vaiyapuri,Priyanka Kadam,Gnaneswar Chandrasekharuni et al.
Sakthivel Vaiyapuri et al.
Snakebite envenoming (SBE) predominantly affects rural impoverished communities that have limited access to immediate healthcare. These communities often hold numerous myths/misbeliefs about snakes and SBE. Moreover, healthcare professional...
Snakebite envenoming at MSF: A decade of clinical challenges and antivenom access issues [0.03%]
MSF十年来蛇咬中毒的临床挑战与抗毒血清获取问题
Julien Potet,Saschveen Singh,Koert Ritmeijer et al.
Julien Potet et al.
The medical humanitarian organization Médecins Sans Frontières (MSF) provides medical care in more than 70 countries and admits more than 7000 cases of snakebite in its facilities each year. We describe our activities against snakebite in...
Histopathological, ultrastructural, and biochemical traits of apoptosis induced by peroxisomicine A1 (toxin T-514) from Karwinskia parvifolia in kidney and lung [0.03%]
来自Karwinskia parvifolia的过氧化物酶体霉素A1（毒素T-514）在肾脏和肺中诱导的细胞凋亡的组织病理学，超微结构及生化特征
Adolfo Soto-Domínguez,Daniel Salas-Treviño,Gloria A Guillén-Meléndez et al.
Adolfo Soto-Domínguez et al.
Peroxisomicine A1 (PA1) is a toxin isolated from the Karwinskia genus plants whose target organs are the liver, kidney, and lung. In vitro studies demonstrated the induction of apoptosis by PA1 in cancer cell lines, and in vivo in the liver...
Perspectives on snakebite envenoming care needs across different sociocultural contexts and health systems: A comparative qualitative analysis among US and Brazilian health providers [0.03%]
不同社会文化背景和卫生系统中关于蛇咬伤护理需求的视角：美国和巴西卫生保健人员之间的比较质性分析
Eleanor Strand,Felipe Murta,Anna Tupetz et al.
Eleanor Strand et al.
With the advancements in therapeutics and available treatment options, almost all deaths and permanent disabilities from snakebite envenoming (SBE) are preventable. The challenge lies in implementing these evidence-based treatments and prac...
Barriers and enablers of community engagement practices for the prevention of snakebite envenoming in South Asia: A qualitative exploratory study [0.03%]
社区参与实践在南亚用于预防蛇咬伤中毒的障碍和促进因素：一项定性探索研究
N J Ten Have,Gaby I Ooms,Benjamin Waldmann et al.
N J Ten Have et al.
Snakebite envenoming (SBE) is a grossly neglected tropical disease (NTD) that predominantly affects those living in rural settings in low-and-middle income countries. South Asia currently accounts for the highest global SBE-related mortalit...
Geoffrey K Isbister
Geoffrey K Isbister
Antivenom is the main treatment for snake envenoming and there are ongoing concerns about availability in resource poor regions of the world. However, effective antivenom treatment for snake envenoming requires more than improved availabili...