Paralysis efficiency (PD50) scales linearly with lethality (LD50) in spider venoms [0.03%]
蜘蛛毒液中麻痹效率(PD50)与致死率(LD50)呈线性关系
Keith Lyons,Dayle Leonard,Leona McSharry et al.
Keith Lyons et al.
Historically, venom potencies have been assessed using measures of lethality, such as the median lethal dose (LD50). However, venoms may be selected primarily for their ability to rapidly incapacitate rather than cause mortality, meaning LD...
The 'jimble', a southern Australia box jellyfish, Carybdea rastonii Haacke, 1886: clinical symptoms, first-aid treatments and species distribution [0.03%]
南澳大利亚方形水母Carybdea rastonii Haacke，1886：临床症状、急救方法和物种分布
N E Meyler,M L Mitchell
N E Meyler
Within the field of jellyfish first-aid treatments, we have identified a distinct lack of evidence-based clinical research, which is most notable among species considered non-lethal. One such species is the southern Australia cubomedusa, Ca...
Adverse neurological events following botulinum toxin type A: A case series of post-injection seizures and paralysis [0.03%]
肉毒杆菌A型注射后的不良神经事件：一组抽动和瘫痪病例报告
Qiaozhen Li,Chunqiu Dai,Hongbin Wang et al.
Qiaozhen Li et al.
Within the field of rehabilitation and aesthetic medicine, botulinum neurotoxin (BoNT), particularly type A (BoNT-A), has gained significant popularity for its unique muscle-relaxing properties including muscular spasticity and reducing wri...
Case Reports
Toxicon: X. 2026 Apr 7:30:100255. DOI:10.1016/j.toxcx.2026.100255 2026
Biochemical characterisation and substrate-specific proteolytic diversity of venom metalloproteinases in African puff adders [0.03%]
非洲球鼻蛇毒液金属蛋白酶的生化特征及底物特异性蛋白水解多样性
Mark C Wilkinson,Cassandra M Modahl,David T K Waterhouse et al.
Mark C Wilkinson et al.
The puff adder (Bitis arietans) is a highly venomous viper responsible for many snakebite fatalities in Africa, yet there have been few geographically comprehensive analyses of its venom proteins, particularly of the proteases that play a k...
Corrigendum to "Epidemiological and geodemographic patterns of scorpionism in Ecuador: A nationwide analysis (2021-2024)" [Toxicon X 26(2025) 1-6/100218] [0.03%]
对“厄瓜多尔全境（2021-2024年）蝎子伤的流行病学和地理人口统计模式分析”[Toxicon X 26(2025) 1-6/100218]的勘误通知
Jorge Vasconez-Gonzalez,Juan S Izquierdo-Condoy,Camila Miño et al.
Jorge Vasconez-Gonzalez et al.
[This corrects the article DOI: 10.1016/j.toxcx.2025.100218.]. © 2025 The Author(s).
Published Erratum
Toxicon: X. 2026 Jan 6:29:100241. DOI:10.1016/j.toxcx.2025.100241 2026
Venom variation and the future of antivenom design: Integrating population venomics, evolutionary toxinology, and precision therapeutics [0.03%]
毒液变异与抗蛇毒药物设计的未来：整合人群毒蛋白质组学、进化毒素学和精确治疗学
Emeka John Dingwoke
Emeka John Dingwoke
Snakebite envenoming remains a neglected tropical disease that disproportionately affects rural populations in the tropical regions, where access to timely and effective treatment is often limited. Conventional antivenoms, produced by immun...
Quantifying venom in African snakes: Insights into protein content, yield and body size associations [0.03%]
量化非洲蛇的毒液：关于蛋白质含量、产率及与体型关联的见解
Stephanie French,Rachael Da Silva,Martijn Ten Have et al.
Stephanie French et al.
Snake venoms are complex mixtures primarily composed of toxic proteins used during prey capture and defence. There is limited knowledge concerning the protein concentration of snake venom and the biases of different protein determination me...
Proteomic analysis of FACS-enriched whole nematocysts from the colonial hydrozoan Hydractinia symbiolongicarpus [0.03%]
海葵共生寡缘长足水母纲刺细胞的富集及蛋白质组分析
Anna M L Klompen,Kevin Ferro,Cassandra G Kempf et al.
Anna M L Klompen et al.
Cnidarians possess a cell-based venom system in the form of nematocytes or "stinging cells" that are found across various tissues. The scattered distribution of these venom-containing cells makes isolation difficult, particularly for proteo...
From association to inference: polyvalent antivenom and response-based algorithms in the Craspedocephalus malabaricus complex: Comment on "Sentinels of the Western Ghats - envenoming by the Malabar pit viper (Craspedocephalus malabaricus): a sub-analysis of the VENOMS registry" [0.03%]
从关联到推理：Malabar拟矛头蛇复合体中的多价抗蛇毒血清和基于反应的算法：对“西高止山脉的守卫者——Malabar矛头腹蛇（Craspedocephalus malabaricus）中毒：VENOMS注册表中的亚分析”的评论
•Registry associations should not be overinterpreted as antivenom efficacy in Malabar pit viper envenoming.•Response-based algorithms risk implying causality without controlled evidence.•Prospective multicentre studies are needed before ...
In vitro- in vivo discord: A preclinical study of AZD2716 and its racemate with comparison to varespladib for the development of snake venom sPLA2 inhibitors [0.03%]
体外和体内不一致：AZD2716及其消旋体的临床前研究与其针对蛇毒sPLA2抑制剂的发展与varespladib进行比较
James L Hearth,Yulia Surovtseva,Zuzana Karjala et al.
James L Hearth et al.
We evaluated a family of repurposed sPLA2 inhibitors as novel candidate snakebite envenoming therapeutics. Stereospecific (R)-7 AZD2716 and its racemic mixture were compared to varespladib in an in vitro sPLA2 assay against a sample of 26 v...