Plug and play virus-like particles for the generation of anti-toxin antibodies [0.03%]
用于生成抗毒抗体的即插即用病毒样颗粒
Rebecca J Edge,Amy E Marriott,Emma L Stars et al.
Rebecca J Edge et al.
Snakebite is a major global health concern, for which antivenom remains the only approved treatment to neutralise the harmful effects of the toxins. However, some medically important toxins are poorly immunogenic, resulting in reduced effic...
Development of a gold nanoparticle-based novel diagnostic prototype for in vivo detection of Indian red scorpion (Mesobuthus tamulus) venom [0.03%]
一种用于体内检测印度红蝎（Mesobuthus tamulus）毒液的新型金纳米颗粒诊断原型的开发
Upasana Puzari,Mojibur R Khan,Ashis K Mukherjee
Upasana Puzari
Indian red scorpion Mesobuthus tamulus is responsible for substantial mortality in India and Sri Lanka; however, no specific diagnostic method is available to detect the venom of this scorpion in envenomed plasma or body fluid. Therefore, w...
Pilot-scale evaluation of a dynamic body-feed filtration system for primary clarification of snake antivenoms produced by the caprylic acid method [0.03%]
辛酸法生产蛇毒免疫球蛋白精浆预处理阶段动态进料过滤系统的中试评估研究
Andrés Sánchez,Maykel Cerdas,Jairo Gutiérrez et al.
Andrés Sánchez et al.
The performance of dynamic body-feed filtration (DBF) in the removal of bulky solids produced during the manufacturing of snake antivenoms using the caprylic acid method was evaluated. For this purpose, diatomites with different filterabili...
Generation of chicken-based IgY polyclonal antibodies against Dendroaspis polylepis and preclinical evaluation of envenomation-neutralizing efficacy vis-à-vis selected commercial antivenoms [0.03%]
利用鸡产生抗黑曼巴蛇毒多克隆IgY抗体及其候选抗蛇毒的临床前评估研究
Stephen Wilson Kpordze,Victor Atunga Mobegi,Gideon Mutie Kikuvi et al.
Stephen Wilson Kpordze et al.
The Black mamba, D. polylepis, is one of the many venomous snakes found in Kenya, and known to account for some snakebite incidents. The Kenyan Ministry of Health data reveals annual 15,000 snakebites occurrences. Also, 1 in 15 people in Ke...
Cyanotoxin accumulation and growth patterns of biocrust communities under variable environmental conditions [0.03%]
不同环境条件下的生物地壳类毒素积累及生长模式分析
Aspassia D Chatziefthimiou,James S Metcalf,William B Glover et al.
Aspassia D Chatziefthimiou et al.
Biocrusts dominate the soil surface in deserts and are composed of diverse microbial communities that provide important ecosystem services. Cyanobacteria in biocrusts produce many secondary metabolites, including the neurotoxins BMAA, AEG, ...
Biochemical and biological characterization of the venoms of Naja kaouthia and Naja mandalayensis from Myanmar and neutralization effects of BPI cobra antivenom [0.03%]
缅甸眼镜蛇(Naja kaouthia)和曼德勒眼镜蛇(Naja mandalayensis)的生物化学及生物学研究及其血液免疫原中和效应研究
Mya Nila Win,Khin Than Yee,Kyae Mhon Htwe et al.
Mya Nila Win et al.
Snakebite is a neglected public health issue, with many scientific and medical issues to be solved. Cobras are among the most common venomous snakes in Myanmar and are responsible for a considerable number of severe snakebite envenoming. Th...
Cytokines and their regulators in rat lung following scorpion envenomation [0.03%]
毒蝎蜇伤后大鼠肺组织细胞因子及其调节机制
Valery Gunas,Oleksandr Maievskyi,Tatyana Synelnyk et al.
Valery Gunas et al.
Nowadays, more than two billion inhabitants of underdeveloped tropical and subtropical countries are at risk of being stung by scorpions. Scorpion stings annually cause 2000-3000 deaths as they can lead to the respiratory and/or cardiovascu...
Development of a membrane-disruption assay using phospholipid vesicles as a proxy for the detection of cellular membrane degradation [0.03%]
开发一种膜破裂测定法，使用磷脂小囊作为检测细胞膜降解的代理方法
Mátyás A Bittenbinder,Eric Wachtel,Daniel Da Costa Pereira et al.
Mátyás A Bittenbinder et al.
Snakebite envenoming is a global health issue that affects millions of people worldwide, and that causes morbidity rates surpassing 450,000 individuals annually. Patients suffering from snakebite morbidities may experience permanent disabil...
Assessment of the Artemia salina toxicity assay as a substitute of the mouse lethality assay in the determination of venom-induced toxicity and preclinical efficacy of antivenom [0.03%]
Artemia 盐水虾毒性试验在毒液诱导的毒性及抗蛇毒血清临床前疗效测定中替代小鼠致死性试验的效果评估
Xavier Araya,Mitchel Okumu,Gina Durán et al.
Xavier Araya et al.
Mice are routinely used in snake venom research but are costly and subject to pain and suffering. The crustacean Artemia salina could be an alternative to mice, but data to support its adoption in snake venom research is limited. The aim of...
High throughput identification of human monoclonal antibodies and heavy-chain-only antibodies to treat snakebite [0.03%]
高通量鉴定治疗蛇咬伤的人单克隆抗体和仅重链抗体
Julien Slagboom,Abigail H Lewis,Wietse M Schouten et al.
Julien Slagboom et al.
Snakebite envenoming is a priority Neglected Tropical Disease that causes an estimated 81,000-135,000 fatalities each year. The development of a new generation of safer, affordable, and accessible antivenom therapies is urgently needed. Wit...