Drugs from poisonous plants: Ethnopharmacological relevance to modern perspectives [0.03%]
有毒植物中的药物：从传统药用价值到现代观点的医药学意义
Bhagya Lakhmi Rajbongshi,Ashis K Mukherjee
Bhagya Lakhmi Rajbongshi
The world of plant diversity is endlessly fascinating and essential for life on Earth. Since the inception of early civilization, humans have utilized plants for several purposes, particularly for their medicinal value. While some plants ar...
Feasibility study: Varespladib protects CD-1 mice from lethal doses of whole bee (Apis mellifera) venom [0.03%]
可行性研究：Varespladib可保护CD-1小鼠免受蜂毒（Apis mellifera）致死剂量的侵害
James Hearth,Kaitlin Linne,Jerry Harrison et al.
James Hearth et al.
Swarming Hymenoptera attacks can deliver high cumulative doses of venom resulting in death and life-threatening or chronically disabling injuries. Varespladib, a potent inhibitor of snake venom secretory PLA2 (sPLA2), is a relatively weak i...
A polygeneric immunogen composed of 22 venoms from sub-Saharan African snakes to expand the neutralization scope of the EchiTAb-plus-ICP antivenom [0.03%]
一种由22种非洲蛇毒液组成的多属免疫原，可扩大EchiTAb-plus-ICP抗蛇毒血清的中和范围
Andrés Sánchez,Gina Durán,Maykel Cerdas et al.
Andrés Sánchez et al.
Recent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-pl...
Stress levels, hematological condition, and productivity of plasma-producing horses used for snake antivenom manufacture: A comparison of two industrial bleeding methods [0.03%]
用于生产蛇抗 venom 马的应激水平、血液学状况和生产力：两种工业取血方法的比较
Ana Margarita Arias-Esquivel,Edwin Moscoso,Deibid Umaña et al.
Ana Margarita Arias-Esquivel et al.
The immunization and industrial bleeding of horses are essential stages for producing snake antivenoms. In Costa Rica, the traditional method involves stimulating the antibody response of horses by periodically injecting venoms, collecting ...
Diagnosis of human envenoming by terrestrial venomous animals: Routine, advances, and perspectives [0.03%]
陆生毒动物致中毒的诊断：现状、进展与展望
Joeliton S Cavalcante,Sabrina Santana Toledo Arruda,Pedro Marques Riciopo et al.
Joeliton S Cavalcante et al.
Despite the development of new and advanced diagnostic approaches, monitoring the clinical evolution of accidents caused by venomous animals is still a challenge for science. In this review, we present the state of the art of laboratory tes...
Supplementation of polyclonal antibodies, developed against epitope-string toxin-specific peptide immunogens, to commercial polyvalent antivenom, shows improved neutralization of Indian Big Four and Naja kaouthia snake venoms [0.03%]
多价抗蛇毒血清中补充针对表位串毒素特异性肽免疫原产生的多克隆抗体，可改善对印度四大蛇及尖吻腹蛇蛇 venom 的中和作用
Abhishek Chanda,Nitin C Salvi,Pravin V Shelke et al.
Abhishek Chanda et al.
Snakebites profoundly impact the rural population of tropical nations, leading to significant socio-economic repercussions. Polyvalent antivenom (PAV) therapy faces several limitations, including intra-specific variations and poor efficacy ...
Bioprospection of rattlesnake venom peptide fractions with anti-adipose and anti-insulin resistance activity in vitro [0.03%]
一种响尾蛇肽分数的生物勘探及其体外抗脂肪和胰岛素抵抗活性
David Meléndez-Martínez,Erika Ortega-Hernández,Edwin Estefan Reza-Zaldívar et al.
David Meléndez-Martínez et al.
Animal venoms are natural products that have served as a source of novel molecules that have inspired novel drugs for several diseases, including for metabolic diseases such as type-2 diabetes and obesity. From venoms, toxins such as exendi...
A probabilistic hazard assessment for cyanobacterial toxins accounting for regional geography and water body trophic status [0.03%]
考虑地区地理和水体营养状况的蓝藻毒素概率性危害评估方法研究
Diane A Mielewczyk,Chris N Glover,Gavin N Saari
Diane A Mielewczyk
Under climate change scenarios freshwater eutrophication is expected to increase, and with it the occurrence of cyanobacterial toxin-producing harmful algal blooms. In the current study, microcystin toxin occurrence data from literature sou...
Design, development and preclinical assessment of MENAVip-ICP, a new snake antivenom with potential coverage of species in the Middle East and North Africa regions [0.03%]
一种新的蛇咬抗蛇毒血清MENAVIP-ICP的设计、开发和临床前评估，可潜在覆盖中东及北非地区的蛇种
Álvaro Segura,Edwin Moscoso,Deibid Umaña et al.
Álvaro Segura et al.
Snakebite in the Middle East and North Africa (MENA) is a public health problem whose magnitude is not fully known. Several antivenoms are available in these regions, but these formulations are designed for restricted geographical settings....
Stroke as a rare complication of scorpion stings: A systematic review and analysis [0.03%]
蝎子蛰伤的罕见并发症——卒中：系统性回顾与分析
Jorge Vasconez-Gonzalez,Karen Delgado-Moreira,Esteban Gamez-Rivera et al.
Jorge Vasconez-Gonzalez et al.
Approximately 1 million scorpion stings are recorded annually worldwide, resulting in 3000 deaths. Scorpion venom has various effects on the human body, with neurological complications occurring in about 2% of cases. Among these complicatio...