Identification, description and structural analysis of beta phospholipase A2 inhibitors (sbβPLIs) from Latin American pit vipers indicate a binding site region for basic snake venom phospholipases A2 [0.03%]
来自南美矛头蝮的β型磷脂酶A2抑制剂的鉴定、描述及结构分析表明了与碱性蛇毒磷脂酶A2结合位点区域的关系
Consuelo Latorre Fortes-Dias,Carlos Alexandre H Fernandes,Paula Ladeira Ortolani et al.
Consuelo Latorre Fortes-Dias et al.
Several snake species possess, in their circulating blood, endogenous PLA2 inhibitors (sbPLIs) with the primary function of natural protection against toxic enzymes from homologous and heterologous venoms. Among the three structural classes...
Spatial variability and depuration of tetrodotoxin in the bivalve Paphies australis from New Zealand [0.03%]
新西兰鲍氏珍珠梅草虫体内的河豚毒素的空间变异性及消除作用
Laura Biessy,Kirsty F Smith,D Tim Harwood et al.
Laura Biessy et al.
Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications globally. Despite its potency and widespread occurrence in taxonomically diverse species, the primary source of TTX remains uncertain. Paphies australis, an ...
Detection and quantification of a β-neurotoxin (crotoxin homologs) in the venom of the rattlesnakes Crotalus simus, C. culminatus and C. tzabcan from Mexico [0.03%]
墨西哥响尾蛇（Crotalus simus，Crotalus culminatus和Crotalus tzabcan）毒液中β神经毒素（crotoxin同源物）的检测与定量
Edgar Neri-Castro,Arely Hernández-Dávila,Alejandro Olvera-Rodríguez et al.
Edgar Neri-Castro et al.
Snake venom may vary in composition and toxicity across the geographic distribution of a species. In the case of the three species of the Neotropical rattlesnakes Crotalus simus, C. culminatus and C. tzabcan recent research has revealed tha...
An oligoclonal combination of human monoclonal antibodies able to neutralize tetanus toxin in vivo [0.03%]
一组能够体内中和破伤风毒素的人源单克隆抗体组合
Eduardo Aliprandini,Daniela Yumi Takata,Ana Lepique et al.
Eduardo Aliprandini et al.
The use of antibody-based therapy to treat a variety of diseases and conditions is well documented. The use of antibodies as an antidote to treat tetanus infections was one of the first examples of immunotherapy and remains the standard of ...
Volker Herzig,Glenn F King,Eivind A B Undheim
Volker Herzig
The rate of discovery of new spider species greatly exceeds the rate of spider venom characterisation, leading to an increasing number of species with unstudied venoms. However, recent advances in proteomics and genomics that enable the stu...
José María Gutiérrez
José María Gutiérrez
Snakebite envenomings occur in complex ecological, social, economic, cultural, and political contexts. Hence, the understanding of this public health issue demands systemic and holistic approaches. Ecohealth constitutes a valuable paradigm ...
Duplication of clostridial binding domains for enhanced macromolecular delivery into neurons [0.03%]
通过复制芽孢杆菌结合域来增强大分子向神经元内部的输送
Charlotte Leese,Rebecca Bresnahan,Ciara Doran et al.
Charlotte Leese et al.
Neurological diseases constitute a quarter of global disease burden and are expected to rise worldwide with the ageing of human populations. There is an increasing need to develop new molecular systems which can deliver drugs specifically i...