Biochemistry and toxicology of proteins and peptides purified from the venom of Vipera berus berus [0.03%]
从Vipera berus berus毒液中纯化的蛋白质和肽的生化和毒性研究
Jüri Siigur,Ene Siigur
Jüri Siigur
The isolation and characterization of individual snake venom components is important for a deeper understanding of the pathophysiology of envenomation and for improving the therapeutic procedures of patients. It also opens possibilities for...
Proteomic insight into the venom composition of the largest European rear-fanged snake, Malpolon monspessulanus monspessulanus [0.03%]
蛋白质组学视角下的最大欧洲后fang蛇(Malpolon monspessulanus monspessulanus)的毒液组成分析
Dominique Koua,Anicet Ebou,Zeinab Habbouche et al.
Dominique Koua et al.
Snake envenomations constitute a worldwide neglected tropical disease, with the vast majority of lethal bites inflicted by front-fanged snakes from the viperid and elapid groups. Rear-fanged snakes (colubrids) were often considered harmless...
Dopaminergic metabolism is affected by intracerebral injection of Tb II-I isolated from Tityus bahiensis scorpion venom [0.03%]
从Tityus bahiensis蝎子毒液中分离的Tb II-I对脑内多巴胺代谢的影响
Beraldo-Neto Emidio,Lebrun Ivo,Nencioni Ana Leonor Abrahao
Beraldo-Neto Emidio
Tb II-I isolated from Tityus bahiensis venom causes epileptic-discharges when injected into the hippocampus of rats. The involvement of neurotransmitters in this activity was investigated. Our results demonstrated that Tb II-I increases the...
Evaluation of lethality and cytotoxic effects induced by Naja ashei (large brown spitting cobra) venom and the envenomation-neutralizing efficacy of selected commercial antivenoms in Kenya [0.03%]
奈aja ashei（大褐喷 Cobra）毒液引起的致死性和细胞毒性效应以及肯尼亚所选商用抗蛇毒血清的解毒功效评估
Ernest Z Manson,Mutinda C Kyama,Joseph K Gikunju et al.
Ernest Z Manson et al.
Neutralization of lethality in mice model at the preclinical level has been established by the World Health Organization as the gold standard for the evaluation of antivenom efficacy. The assessment of the neutralization profiles of antiven...
Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality [0.03%]
三种抗蛇毒血清对黑眉锯鳞蝰(Naja ashei)蛇毒致死作用的预防效果的临床前评估研究
Mitchel Otieno Okumu,James Mucunu Mbaria,Joseph Kangangi Gikunju et al.
Mitchel Otieno Okumu et al.
This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy o...
The myth of cobra venom cytotoxin: More than just direct cytolytic actions [0.03%]
Cobra毒液细胞毒素的迷思：不仅仅是直接的细胞溶解作用
Jia Jin Hiu,Michelle Khai Khun Yap
Jia Jin Hiu
Cobra venom cytotoxin (CTX) is a non-enzymatic three-finger toxin that constitutes 40-60% of cobra venom. Thus, it plays an important role in the pathophysiology of cobra envenomation, especially in local dermonecrosis. The three-finger hyd...
Non-compartmental toxicokinetic studies of the Nigerian Naja nigricollis venom [0.03%]
尼日利亚黑颈 Cobra(Naja nigricollis)毒素的非隔室毒动学研究
Auwal A Bala,Sani Malami,Yusuf Abubakar Muhammad et al.
Auwal A Bala et al.
Snakebite envenoming (SBE) is a neglected public health problem, especially in Asia, Latin America and Africa. There is inadequate knowledge of venom toxicokinetics especially from African snakes. To mimic a likely scenario of a snakebite e...
Does probiotic Kefir reduce dyslipidemia, hematological disorders and oxidative stress induced by zearalenone toxicity in wistar rats? [0.03%]
开菲尔益生菌能否降低Wistar大鼠中玉米赤霉烯酮毒性引起的脂质异常、血液紊乱和氧化应激？
Fadia Ben Taheur,Chalbia Mansour,Sondes Mechri et al.
Fadia Ben Taheur et al.
Zearalenone (ZEA) is a toxic metabolite of the genus Fusarium, which causes hepatotoxicity and induces oxidative stress. Kefir is an important probiotic dairy-product showing important in vitro antioxidant potential. In this study, the effe...
Profiling hymenopteran venom toxins: Protein families, structural landscape, biological activities, and pharmacological benefits [0.03%]
膜翅目毒液毒素的特征分析：蛋白质家族、结构景观、生物学活性和药理效益
Juan Carlos Guido-Patiño,Fabien Plisson
Juan Carlos Guido-Patiño
Hymenopterans are an untapped source of venom secretions. Their recent proteo-transcriptomic studies have revealed an extraordinary pool of toxins that participate in various biological processes, including pain, paralysis, allergic reactio...
Antifungal activity of Rhopalurus crassicauda venom against Candida spp [0.03%]
秘鲁角突武碌蛛的毒液对念珠菌属的抗真菌活性研究
Umberto Zottich,Isadora Sousa de Oliveira,Isabela Gobbo Fereira et al.
Umberto Zottich et al.
Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus Candida. So far, fungal infection treatment faces different challenges, including the limited number...