Topical minocycline formulations: Evaluation and comparison of dermal uptake efficacy [0.03%]
评价和比较 topical minocycline 制剂的经皮吸收效力
Diana Lac,Maiko Hermsmeier,Xin Chen et al.
Diana Lac et al.
Acne vulgaris is a clinically distinct skin condition with evidence suggesting that inflammation plays a critical role in the pathogenesis of this disorder. Treatment of severe inflammatory acne often involves the use of oral antibiotics, s...
The role interplay between mesoporous silica pore volume and surface area and their effect on drug loading capacity [0.03%]
介孔二氧化硅的孔隙体积和比表面积的作用及对载药量的影响
Christoffer G Bavnhøj,Matthias M Knopp,Cecilie M Madsen et al.
Christoffer G Bavnhøj et al.
In this study, the influence of the mesoporous silica (MS) textural properties (surface area, pore diameter, and pore volume) on drug loading capacity (monomolecular loading capacity and pore filling capacity) was investigated theoretically...
Chitosan/β-glycerophosphate in situ gelling mucoadhesive systems for intravesical delivery of mitomycin-C [0.03%]
壳聚糖/β-甘油磷酸在体内凝胶化粘附系统用于丝裂霉素C的膀胱给药
Oluwadamilola M Kolawole,Wing Man Lau,Vitaliy V Khutoryanskiy
Oluwadamilola M Kolawole
The development of mucoadhesive in situ gelling formulations for intravesical application may improve the therapeutic outcomes of bladder cancer patients. In this work, chitosan/β-glycerophosphate (CHIGP) thermosensitive formulations have ...
Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate [0.03%]
壳聚糖包载的醇溶蛋白纳米颗粒对玉米糊化粉体特性的影响研究
Laura Inchaurraga,Ana L Martínez-López,Muthanna Abdulkarim et al.
Laura Inchaurraga et al.
The aim of this work was to evaluate the mucus-permeating properties of nanocarriers using zein nanoparticles (NPZ) coated with a Gantrez® AN-thiamine conjugate (GT). NPZ were coated by incubation at different GT-to-zein ratios: 2.5% coati...
Model-based approach to the design of pharmaceutical roller-compaction processes [0.03%]
基于模型的制药滚压工艺设计方法学研究进展
Peter Toson,Diogo G Lopes,Raphael Paus et al.
Peter Toson et al.
This work presents a new model based approach to process design and scale-up within the same equipment of a roller compaction process. The prediction of the operating space is not performed fully in-silico, but uses low-throughput experimen...
Predicting capsule fill weight from in-situ powder density measurements using terahertz reflection technology [0.03%]
基于太赫兹反射技术的粉体密度在线检测及其预测胶囊填充量的研究
Sandra Stranzinger,Eva Faulhammer,Jingyi Li et al.
Sandra Stranzinger et al.
The manufacturing of the majority of solid oral dosage forms is based on the densification of powder. A good understanding of the powder behavior is therefore essential to assure high quality drug products. This is particularly relevant for...
Hyaluronic acid/silk fibroin nanoparticles loaded with methotrexate for topical treatment of psoriasis [0.03%]
透明质酸/丝素蛋白纳米粒载甲氨蝶呤治疗银屑病的研究
Systemic administration of methotrexate (MTX), widely regarded as one of the most effective treatments for psoriasis, poses significant challenges due to its high toxicity, limited solubility, and potential for adverse effects. Consequently...