A blood-brain barrier-penetrating nanoreactor for tumor microenvironment modulation, precise MR imaging and synergistic therapy of glioma [0.03%]
一种用于肿瘤微环境调控、精准MRI成像及胶质瘤协同治疗的能穿越血脑屏障的纳米反应器
Peipei Dou,Liang Chen,Yiyang Xie et al.
Peipei Dou et al.
Nanomaterials-based theranostic strategy have emerged as innovative techniques for gliomas treatment. However, the existence of blood-brain barrier (BBB) hinders efficient drug delivery to glioma, and the hypoxic condition of tumor microenv...
Ionto phoretic delivery of caspofungin acetate to the cornea and sclera and its intracorneal biodistribution [0.03%]
卡泊芬净用于角膜和巩膜的经皮给药及其在角膜中的分布研究
Laura Gisela González Iglesias,Yogeshvar N Kalia
Laura Gisela González Iglesias
Caspofungin (CAS) is a potent antifungal agent belonging to the echinocandin family. It is a water-soluble dication at physiological pH, making it a good candidate for iontophoresis. Intracorneal iontophoretic delivery and biodistribution o...
Extraction of the polysorbate 20 and 80 fingerprint via generative modeling [0.03%]
基于生成模型的聚山梨酯20和80指纹提取方法研究
Peter Roelants,Reza Ranjbar Choubeh,Nico Verbeeck et al.
Peter Roelants et al.
Polysorbate 20 (PS20) and polysorbate 80 (PS80) are essential surfactants used to stabilize biopharmaceutical products, yet their highly heterogeneous mixtures and susceptibility to oxidation and enzymatic hydrolysis complicate routine anal...
CD276-directed supramolecular nanoplatform with pH-triggered gemcitabine release for potent tumor stromal and vascular suppression [0.03%]
一种基于CD276的超分子纳米平台通过pH触发吉西他滨释放，用于强力肿瘤基质和血管抑制
Jiayi Li,Hao Liu,Zhijun Li et al.
Jiayi Li et al.
Gemcitabine (Gem) remains a cornerstone chemotherapy for pancreatic ductal adenocarcinoma, but its clinical efficacy is limited by poor pharmacokinetics, dense fibrotic stroma, and hypovascularization. While pH-responsive liposomes can enha...
Bioinspired pH-sensitive liposomes for quercetin delivery to synergize with 5- FU in gastric cancer therapy [0.03%]
仿生pH响应型载檞皮素脂质体以协同氟尿嘧啶治疗胃癌
Qinghua Lan,Miao Wang,Yanyan Zhu et al.
Qinghua Lan et al.
Gastric cancer is a major cause of cancer-related mortality on a global scale. Although 5-fluorouracil (5-FU) is a cornerstone chemotherapeutic for digestive tract malignancies, its efficacy is limited by dose-dependent toxicity and acquire...
Oral delivery of chitosan/hyaluronic-acid-coated milk-derived exosomes for ulcerative-colitis amelioration [0.03%]
壳聚糖/透明质酸包被的牛奶外泌体口服给药改善溃疡性结肠炎
Chao Deng,Xinyi Cheng,Qingying Sun et al.
Chao Deng et al.
Restoring intestinal-barrier homeostasis is crucial in treating ulcerative colitis (UC). Milk-derived exosomes, known for their potent biological properties, hold promise in promoting intestinal-barrier repair. However, their stability and ...
Spray drying: From a traditional technology to modern biotechnological applications [0.03%]
喷雾干燥技术：从传统加工到现代生物技术应用
Andrea Milanesi,Giada Diana,Alessandro Candiani et al.
Andrea Milanesi et al.
Spray drying, first patented in the late 19th century, has evolved into a versatile technology for converting liquid feeds into stable, free-flowing powders. Its fundamental strength lies in the rapid atomization and solvent evaporation. It...
Preparation and in vitro property evaluation of NO-HA@ICG self-assembled nanoparticles for gas therapy synergized with phototherapy [0.03%]
一种用于光动力治疗协同气体治疗的NO-HA@ICG自组装纳米粒子的制备及体外性能评价研究
Jiamin Huang,Jianhu Jia,Qian Zhang et al.
Jiamin Huang et al.
The synergistic effect of gas therapy and phototherapy is an innovative therapy in the field of cancer treatment with a unique therapeutic mechanism and application characteristics. NO improves the tumor blood vessels and facilitates the dr...
Biomimetic nanotherapy for P. gingivalis-infected oral squamous cell carcinoma: Photothermal therapy and immunoactivation via precise intracellular bacterial elimination [0.03%]
牙龈卟啉单胞菌感染的口腔鳞状细胞癌类生物纳米治疗：通过精确的细菌胞内消除进行光热疗法和免疫激活
Zihan Dai,Qiaoxin Li,Longxuan Guo et al.
Zihan Dai et al.
Porphyromonas gingivalis (P. gingivalis) infection in oral squamous cell carcinoma (OSCC) undermines patient responses to standard therapies by driving chemoresistance, tumor progression, and immune suppression. Mounting research evidence-i...
J Siepmann,F Siepmann
J Siepmann
Poly(lactic-co-glycolic acid) (PLGA)-based microparticles and implants are of continuously increasing importance as parenteral controlled drug delivery systems. However, the underlying drug release mechanisms are often not understood, rende...