Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin [0.03%]
Erga Syafitri,Aka Yoann-André Kouassi,Claudia Prezioso et al.
Erga Syafitri et al.
Rice bran oil (RBO) is rich in antioxidants but the high lipophilicity and low concentration of key active components complicate its formulation for topical delivery. The objective of this study was to develop and to optimize an RBO-based n...
A ROS-responsive nanozyme delivering gallic acid synergistically ameliorates chronic rhinosinusitis via epithelial barrier restoration and Syk/NF-κB inhibition [0.03%]
Fangwei Zhou,Shanhu Gao,Tuotuo Xiong et al.
Fangwei Zhou et al.
Background: Chronic rhinosinusitis (CRS) is a prevalent inflammatory disorder characterized by persistent mucosal inflammation and epithelial barrier dysfunction. However, effective therapeutic strategies targeting this c...
Placenta-oriented self-assembled Aspirin-RGDV nanoconjugates attenuate preeclampsia through restoration of angiogenic balance [0.03%]
Ying Zhang,Wenqiang Qian,Yao Yao et al.
Ying Zhang et al.
Pre-eclampsia (PE) is a placenta-originated pregnancy disorder and a leading cause of maternal-fetal morbidity and mortality worldwide. Aspirin is the only widely recommended evidence-based prophylaxis for PE, yet its therapeutic potential ...
Biomineralized outer membrane vesicles for synergistic immuno-photodynamic therapy of oral squamous cell carcinoma [0.03%]
Jingyuan Wang,Guanxiong Zhu,Hongru Zhang et al.
Jingyuan Wang et al.
Immunotherapy against oral squamous cell carcinoma (OSCC) currently exhibits a clinical response rate significantly lower than anticipated, underscoring the need for more effective therapeutic strategies. Outer membrane vesicles (OMVs) repr...
Anti-EGFR liposomal drug delivery system loaded with AGY2 potentiates the anti-cancer effect of AGY2 against EGFR expressed pancreatic cancer [0.03%]
Raviteja Bulusu,Esther Frimpong,Joy Okoro et al.
Raviteja Bulusu et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide due to late diagnosis, dense stromal barriers, and resistance to existing chemotherapeutics. To address these limitations, we developed a targeted...
Development of perilla essential oil-based nanoemulsions as anti-psoriatic and dermal delivery platforms for topical therapy [0.03%]
Zhengwei Zhang,Ji Mu,Shanmin Tao et al.
Zhengwei Zhang et al.
Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, immune dysregulation, and impaired barrier regeneration, highlighting the need for safe and effective topical therapies. Perilla essential o...
Biological activities and safety assessment of Teleogryllus mitratus extracts for skin delivery via nanoemulsion-based systems [0.03%]
Jirasit Inthorn,Pratthana Chomchalao,Saranya Juntrapirom et al.
Jirasit Inthorn et al.
This study aimed to investigate the cosmeceutical effects of cricket extracts and assess their delivery through a nanoemulsion system. Different species of crickets (Gryllus bimaculatus, Teleogryllus mitratus, and Acheta domesticus) were fr...
Unlocking the acquired ultraviolet-resistance and enhanced antioxidant potential of pterostilbene-loaded pharmaceutical-dots [0.03%]
Rujing Wang,Lan Zou,Dandan Mi et al.
Rujing Wang et al.
Ultraviolet (UV) radiation, particularly UVA and UVB, induces skin damage through oxidative stress and inflammation. However, existing UV protection materials fail to simultaneously block UV rays and scavenge reactive oxygen species (ROS). ...
The self-assembly mechanisms of glycyrrhizic acid: Permeation enhancement and transdermal applications [0.03%]
Lin Zhou,Youran Deng,Mingjie Ou et al.
Lin Zhou et al.
Glycyrrhizic acid (GA) is an amphiphilic triterpenoid saponin compound derived from licorice. This review first summarizes the behaviors and evolution mechanisms of GA forming different nanostructures (dimers, micelles, nanoparticles, nanof...
Solvent-free aqueous spray drying of poorly soluble drugs enabled by hot-feed micellar solubilization and high-Tg polymer matrices [0.03%]
Wenling Zheng,Hui Chen,Rongrong Xue et al.
Wenling Zheng et al.
Poor aqueous solubility limits the oral bioavailability of many BCS II drugs, while conventional spray drying of amorphous solid dispersions (ASDs) often relies on organic solvents. Here we develop an aqueous spray-drying (AQSD) strategy th...