Enhanced brain delivery of oleanolic acid by GSH-PEGylated liposomes and its amelioration of scopolamine-induced cognitive dysfunction via multi-target regulation [0.03%]
谷胱甘肽-聚乙二醇修饰的脂质体增强脑内白桦酸递送并通过多靶点调控改善东莨菪碱所致的认知障碍
Yihuo Luo,Xiaokun Hong,Xiaohui Chen et al.
Yihuo Luo et al.
Oleanolic acid (OA) exhibits pronounced neuroprotective effects in the central nervous system; however, its clinical translation is limited by poor solubility and low bioavailability. To overcome these limitations, we developed glutathione-...
Hypoxia-relieving and glycolysis-disrupting polydopamine nanomedicine for synergistic chemo-photothermal therapy of hepatocellular carcinoma [0.03%]
兼具缓解缺氧和干扰糖酵化的聚多巴胺纳米药物协同化疗/光热治疗肝细胞癌
Xiang Wang,Yihan Ma,Le Wang et al.
Xiang Wang et al.
Hypoxia is a hallmark of solid tumors that compromises therapeutic efficacy in hepatocellular carcinoma (HCC). Here, a multifunctional polydopamine (PDA)-based nanomedicine co-loading shikonin (SK) and catalase (CAT) and functionalized with...
GPC3 and CD133-targeted peptide dual modification enhances the therapeutic effect of doxorubicin carried by OMVs on hepatocellular carcinoma [0.03%]
GPC3和CD133靶向肽的双重修饰可增强OMV递送阿霉素治疗肝癌的效果
Zuo Mou,Yuefeng Zhang,Xiaodian He et al.
Zuo Mou et al.
Hepatocellular carcinoma (HCC) has a high mortality rate because of the limitations of conventional chemotherapies (e.g., doxorubicin, DOX), including poor tumor targeting, systemic toxicity, and chemoresistance. Bacterial outer membrane ve...
Jan Appelhaus,Karl G Wagner,Kristina E Steffens
Jan Appelhaus
Mesoporous silica-based liquisolids offer an effective method for transforming liquid or sticky actives, such as cannabis extracts, into free-flowing powders. This approach broadens the formulation strategies available for these actives, wh...
Comparing the efficacy of nanocarriers for cutaneous and follicular delivery of poorly water-soluble molecules: A case study with ciclosporin A [0.03%]
纳米载体用于不良水溶性分子经皮和毛囊给药效力的比较：环孢素A的应用研究
Aditya R Darade,Maria Lapteva,Yogeshvar N Kalia
Aditya R Darade
Therapeutic agents approved for the topical treatment of dermatological diseases have diverse physicochemical properties, but they are frequently poorly water-soluble, which makes it a challenge to prepare stable aqueous formulations with g...
Brain-targeted delivery of siRNA via non-viral delivery systems, the therapeutic strategy for Alzheimer's disease-Unveiling challenges and prospects [0.03%]
非病毒递送系统介导的siRNA大脑靶向递送治疗阿尔茨海默病的挑战与前景
Lili Gu,Jiayi Liu,Can Wang et al.
Lili Gu et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral issues, posing significant public health challenges. Small interfering RNAs (siRNAs) offer the potential to selectively silence AD-related pa...
Gemini surfactant-stabilized cubosomes for enhanced topical delivery of 5-fluorouracil in cutaneous squamous cell carcinoma [0.03%]
双子星表面活性剂稳定立方相胶束增强5-氟尿嘧啶治疗皮肤鳞状细胞癌的经皮给药效果
Ruchira Raychaudhuri,Ajinkya Nitin Nikam,Naitik Jain et al.
Ruchira Raychaudhuri et al.
Cutaneous squamous cell carcinoma (cSCC) is a prevalent non-melanoma skin cancer. Topical chemotherapy offers a non-invasive alternative to surgical treatments, yet the therapeutic efficacy of conventional agents like 5-fluorouracil is hind...
Enhancing islet transplantation outcomes in T1DM: The promise of mesenchymal stem cells and exosomes [0.03%]
间充质干细胞和外泌体在改善T1DM的胰岛移植效果中的应用前景
Ying Zhang,Xiaoyue Chen,Zhuoxun Huang et al.
Ying Zhang et al.
Islet transplantation represents a promising therapeutic strategy for type 1 diabetes mellitus (T1DM), yet its clinical application is constrained by hypoxia, oxidative stress, and immune rejection during islet isolation, culture, and post-...
ROS-triggered smart hydrogel adhesives for modulating the inflammatory microenvironment and promoting tendon-bone interface regeneration [0.03%]
用于调节炎性微环境和促进腱骨界面再生的ROS触发的智能水凝胶粘合剂
Hebei He,Yifen Lin,Jia Fang et al.
Hebei He et al.
Currently, suture surgery for rotator cuff repair is unable to regenerate the original functional fibrocartilage layer at the tendon-bone interface, resulting in high postoperative retear rates. In this study, a ROS-triggered smart hydrogel...
Bioinspired and stimuli-responsive nanocomposites for targeted therapy in ovarian and endometrial tumors [0.03%]
仿生和刺激响应型纳米复合材料在卵巢癌和子宫内膜癌的靶向治疗中的应用
Jihang Yao,Lulu Liu,Xiufei Teng et al.
Jihang Yao et al.
Ovarian and endometrial cancers pose significant therapeutic challenges due to late-stage diagnosis and resistance to traditional therapies. Recent progress in the development of multiscale, bioinspired, and stimuli-responsive nanocomposite...