Comparison of bulk and microfluidics methods for the formulation of poly-lactic- co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures [0.03%]
基于不同结构的细胞穿膜肽修饰的聚乳酸-co-乙醇酸(P L G A)纳米粒的制备及评价：块状法与芯片微流控法制备工艺比较研究
Sarah Streck,Henriette Neumann,Hanne Mørck Nielsen et al.
Sarah Streck et al.
The efficient and reproducible production of nanoparticles using bulk nanoprecipitation methods is still challenging because of low batch to batch reproducibility. Here, we optimize a bulk nanoprecipitation method using design of experiment...
Combination of a rotating tube sample divider and dynamic image analysis for continuous on-line determination of granule size distribution [0.03%]
在线连续测定颗粒粒度分布的旋转管式样品预处理器和动态图象分析仪联用技术
Annika Wilms,Klaus Knop,Peter Kleinebudde
Annika Wilms
The granule size distribution is a critical quality attribute of granules. It has a great impact on further packaging or processing. Due to increasing interest in continuous manufacturing techniques, it is of high interest to develop an in-...
Industrial application of heat- and mass balance model for fluid-bed granulation for technology transfer and design space exploration [0.03%]
用于技术转移和设计空间探索的流化床造粒热力学与质量平衡模型的工业应用
David R Ochsenbein,Matthew Billups,Bingbing Hong et al.
David R Ochsenbein et al.
This work demonstrates the application of state-of-the-art modeling techniques in pharmaceutical manufacturing for fluid bed granulation at varying scales to successfully predict process conditions and ultimately replace experiments during ...
Xiao-Qian Niu,Dan-Ping Zhang,Qiong Bian et al.
Xiao-Qian Niu et al.
Ethosomes are widely used to promote transdermal permeation of both lipophilic and hydrophilic drugs, but the mechanism of interaction between the ethosomes and the skin remains unclear. In this work, it was exploded with several technologi...
Impact of drug loading in mesoporous silica-amorphous formulations on the physical stability of drugs with high recrystallization tendency [0.03%]
药物高重结晶倾向的介孔硅质制剂中药物载药量对其物理稳定性的 影响
Rayane S C M Q Antonino,Michael Ruggiero,Zihui Song et al.
Rayane S C M Q Antonino et al.
In this study, a method is described to determine the monolayer loading capacity (MLC) of the drugs naproxen and ibuprofen, both having high recrystallization tendencies, in mesoporous silica (MS), a well known carrier that is able to stabi...
3-O-ethyl-l-ascorbic acid: Characterisation and investigation of single solvent systems for delivery to the skin [0.03%]
3-O-乙基-L-抗坏血酸：单一溶剂传递体系的特征及皮肤递送研究
Fotis Iliopoulos,Bruno C Sil,David J Moore et al.
Fotis Iliopoulos et al.
l-ascorbic acid (AA), commonly known as vitamin C, has been widely used in topical formulations for many years as an antioxidant and anti-aging ingredient. However, the physicochemical properties of AA are not optimal for skin uptake and th...
Using zeta potential to study the ionisation behaviour of polymers employed in modified-release dosage forms and estimating their pKa [0.03%]
应用电位研究改良释放药物剂型中聚合物的离子行为并估计其pka值
Joao A C Barbosa,Malaz S E Abdelsadig,Barbara R Conway et al.
Joao A C Barbosa et al.
A range of enteric polymers is used in pharmaceutical industry for developing gastro-resistant formulations. It is generally implied that these coatings are interchangeable due to similar dissolution pH thresholds reported by suppliers. Des...
Premium ethylcellulose polymer based architectures at work in drug delivery [0.03%]
药物递送中的优质乙基纤维素聚合物架构
Oluwatoyin A Adeleke
Oluwatoyin A Adeleke
Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely employed as biocompatible templates for the design of novel drug delivery systems. They are classified as United States Food and Drug Administration G...
Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy [0.03%]
采用太赫兹光谱观测冻干蛋白质制剂中的高温宏观限制状态
Talia A Shmool,P J Woodhams,Markus Leutzsch et al.
Talia A Shmool et al.
Characterising the structural dynamics of proteins and the effects of excipients are critical for optimising the design of formulations. In this work we investigated four lyophilised formulations containing bovine serum albumin (BSA) and th...
A synbiotic concept containing spore-forming Bacillus strains and a prebiotic fiber blend consistently enhanced metabolic activity by modulation of the gut microbiome in vitro [0.03%]
一种含有芽孢杆菌菌株和益生元纤维结合物的合生元概念通过调节肠道微生物组持续增强代谢活性（体外研究）
Cindy Duysburgh,Pieter Van den Abbeele,Kiran Krishnan et al.
Cindy Duysburgh et al.
A standardized in vitro simulation of the human gastrointestinal tract (M-SHIME®) was used to assess the effect of repeated daily administration of a synbiotic formulation, containing five spore-forming Bacillus strains and a prebiotic fib...