Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug degradation and crystallinity [0.03%]
热敏和剪切不稳定的药物制备成无定形固体分散体：平衡药物降解与晶型问题
Daniel A Davis Jr,Dave A Miller,Supawan Santitewagun et al.
Daniel A Davis Jr et al.
We seek to further addresss the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and ...
Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel [0.03%]
一种硅酮弹性体配方，用于改善同时输送dapivirine和levonorgestrel的多功能阴道环的性能
Yahya H Dallal Bashi,Diarmaid J Murphy,Clare F McCoy et al.
Yahya H Dallal Bashi et al.
A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development,...
Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro- in vivo correlation of P-glycoprotein inhibition [0.03%]
口服伊立替康和苏拉明在大鼠中的生物利用度：联合给药的影响及P-糖蛋白抑制的体内外相关性研究
Rasmus Blaaholm Nielsen,René Holm,Ils Pijpers et al.
Rasmus Blaaholm Nielsen et al.
P-glycoprotein inhibitors, like zosuquidar, have widely been used to study the role of P-glycoprotein in oral absorption. Still, systematic studies on the inhibitor dose-response relationship on intestinal drug permeation are lacking. In th...
Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson's disease [0.03%]
芽孢杆菌对帕金森病患者肠道微生物组成和肠壁功能的体外影响
Jonas Ghyselinck,Lynn Verstrepen,Frédéric Moens et al.
Jonas Ghyselinck et al.
We report here the potential role of a 4-strain probiotic suspension for use with patients with Parkinson's disease (PD). Stool samples from a group of three patients with diagnosed PD were used to create microbiotas in an in-vitro gut mode...
In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters [0.03%]
吸入给药瑞德西韦干粉在仓鼠体内的药代动力学研究
Sawittree Sahakijpijarn,Chaeho Moon,Zachary N Warnken et al.
Sawittree Sahakijpijarn et al.
Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-4...
Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying [0.03%]
通过熔融挤出，喷雾干燥和真空鼓式干燥制备的非晶固体分散体的压缩
Barbara V Schönfeld,Ulrich Westedt,Karl G Wagner
Barbara V Schönfeld
The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder pro...
Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin [0.03%]
基于Gantrez的卡铂类口服给药纳米颗粒共轭物
Judit Huarte,Socorro Espuelas,Cristina Martínez-Oharriz et al.
Judit Huarte et al.
Camptothecin (CPT) exhibits a number of challenges for its oral administration, including a low aqueous solubility, a lactone ring susceptible to hydrolysis, and an affinity to the intestinal P-gp. The aim of this work was to evaluate nanop...
Tablet formulation development focusing on the functional behaviour of water uptake and swelling [0.03%]
以水分吸收和膨胀性能为核心的片剂制剂研发
Jan Lenz,Jan Henrik Finke,Heike Bunjes et al.
Jan Lenz et al.
The functional behaviour of tablets is strongly influenced by their manufacturing process and the choice of excipients. Water uptake and swelling are prerequisites for tablet disintegration, dispersion and hence active pharmaceutical ingred...
Intravesical drug delivery approaches for improved therapy of urinary bladder diseases [0.03%]
用于改善尿膀胱疾病治疗的膀胱内给药方法
Luca Palugan,Matteo Cerea,Micol Cirilli et al.
Luca Palugan et al.
Diseases of the urinary bladder have high incidence rates and burden healthcare costs. Their pharmacological treatment involves systemic and local drug administration. The latter is generally accomplished through instillation of liquid form...
Downstream processing of spray-dried ASD with hypromellose acetate succinate - Roller compaction and subsequent compression into high ASD load tablets [0.03%]
含羟丙基甲基纤维素醋酸酯的喷雾干燥ASD的下游加工——滚压及后续压片成高ASD载量片剂
Andreas Sauer,Shogo Warashina,Saurabh M Mishra et al.
Andreas Sauer et al.
Despite wide commercial application of hypromellose acetate succinate (HPMCAS) in spray-dried amorphous solid dispersion (ASD) drug products, little information is available in the references on downstream processing of spray-dried dispersi...