Can therapeutic potency of a cancer nanomedicine be predicted by pain-related behavioral test in subcutaneous tumor model? [0.03%]
癌纳米药物的镇痛效果能否预测其抗肿瘤疗效？
Ye Tao,Xiaohui Cai,Zhongping Chen
Ye Tao
Cancer nanomedicines have shown great potential in fighting against cancer. While the development of cancer nanomedicines is advancing rapidly, preclinical assessment approaches for their therapeutic potency have stagnated. In view of high ...
In vitro, ex vivo, and in vivo evaluation of ophthalmic ointments containing dexamethasone and tobramycin [0.03%]
含有地塞米松和妥布霉素的眼膏的体外、离体及体内评价
Catheleeya Mekjaruskul,Andre O&#x;Reilly Beringhs,Tuo Meng et al.
Catheleeya Mekjaruskul et al.
This investigation compares in vitro release, ex vivo release and permeation, and in vivo ocular pharmacokinetics to render biologically informed evaluations of ophthalmic semi-solid drug products containing dexamethasone (hydrophobic) and ...
Gold-incorporated hyaluronic acid nanoparticles enhance ablative radiotherapy efficacy in lung cancer [0.03%]
负载金颗粒的透明质酸纳米粒子增强肺癌消融放疗疗效研究
Jenny Ling-Yu Chen,Shu-Jyuan Yang,Li-Cheng Lin et al.
Jenny Ling-Yu Chen et al.
We aimed to investigate the utility of Au-incorporated hyaluronic acid nanoparticles (Au/HA NPs) for improving the therapeutic efficacy of ablative radiotherapy (RT) for tumor control and microenvironment remodeling. HA-functionalized NPs e...
Engineering exosomes for cancer therapy - Modification technologies and subcellular targeting strategies: A review [0.03%]
工程化外泌体用于癌症治疗-修饰技术和亚细胞靶向策略：综述文章
Fengbo Liu,Chengxing Xia,Hang Yu et al.
Fengbo Liu et al.
Exosomes are secreted lipid bilayer vesicles of 30-150 nm in diameter. Their low immunogenicity, excellent biocompatibility, and inherent targeting capability make them a promising drug delivery vehicle for cancer therapeutics. However, the...
Hydrogel-encapsulated antioxidant nanotherapeutics against age-related macular degeneration (AMD) oxidative damage [0.03%]
用于治疗年龄相关性黄斑变性的抗氧化纳米药物水凝胶胶囊化对抗氧化损伤
Jiemeng Xu,Taoyang Cai,Jing Li et al.
Jiemeng Xu et al.
Age-related macular degeneration (AMD) is still the main cause of irreversible vision loss, and the current intravitreal injections is limited by frequent administration and short retinal residence time. This review summarizes the latest pr...
3D printed system using ex vivo porcine eye globes to investigate intracorneal absorption of dexpanthenol from contact lens care solution and eye drops [0.03%]
利用3D打印系统研究猪眼离体眼球中从隐形眼镜护理液和滴眼液的泛醇向角膜内的吸收行为
Verena Santer,Adyl-Michaёl El Guamra,Tohru Kawaguchi et al.
Verena Santer et al.
Reduction of the use of animal models in research is encouraged for the sake of animal wellbeing. However, available in vitro models in the specific case of topical ocular delivery/penetration studies are often oversimplified by the use of ...
Development and evaluation of clotrimazole microemulsions for topical application: Effects of HLB value of surfactant mixture and cosurfactant type on formulation design [0.03%]
克霉唑微乳液的设计开发及其评价：表面活性剂HLB值及助表面活性剂类型对制备工艺的影响
Chih-Wun Fang,Yu-Wen Lin,I-Hui Chiu et al.
Chih-Wun Fang et al.
Clotrimazole is a synthetic imidazole with broad-spectrum antimycotic effect that has been widely used for the topical treatment for athlete's foot (tinea pedis), oropharyngeal and vulvovaginal candidiasis. The objective of the study was to...
Ensuring vaccine cold chain integrity: A rapid and low-cost test for identifying heat-exposed sucrose-containing vaccines [0.03%]
确保疫苗冷链的完整性：一种快速低成本测试方法可识别受热的含蔗糖疫苗
Benediktus Yohan Arman,Andrea Magri,Matteo N Barbaglia et al.
Benediktus Yohan Arman et al.
Maintaining cold-chain integrity is vital for vaccines to ensure that they remain within the recommended temperature limits during routine storage and transportation. This ensures vaccine stability, efficacy, and avoids degradation. Here, w...
Photothermally-activated nano-delivery system for on-demand treatment of diabetic wound infections [0.03%]
糖尿病伤口感染的按需治疗光热激活纳米输送系统
Rong Huang,Wenjia Yang,Tao Wang et al.
Rong Huang et al.
Bacterial-infected diabetic wounds, characterized by a persistent hyperglycemic environment, susceptibility to secondary bacterial infections, and chronic inflammatory responses, often exhibit impaired healing processes, posing a significan...
A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin [0.03%]
一种以瑞鲍迪侧素A为基础的新型纳米微团：增强白杨 flavone 的肾保护作用的口服纳米平台
Tian Wang,Zhen Gao,Chuanlong Guo et al.
Tian Wang et al.
Cisplatin-induced acute kidney injury (AKI) is a significant clinical challenge, primarily characterized by inflammatory responses and oxidative stress. This study aimed to develop a myricetin (Myr) loaded Rebaudioside A (RA) nanomicelle de...