Multimodal imaging reveals membrane skeleton reorganisation during reticulocyte maturation and differences in dimple and rim regions of mature erythrocytes [0.03%]
多模态成像揭示了网织红细胞成熟过程中膜骨架的重塑及成熟红细胞窝区和边缘区差异
Adam J Blanch,Juan Nunez-Iglesias,Arman Namvar et al.
Adam J Blanch et al.
The red blood cell (RBC) is remarkable in its ability to deform as it passages through the vasculature. Its deformability derives from a spectrin-actin protein network that supports the cell membrane and provides strength and flexibility, h...
Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3 [0.03%]
RhoGEF P-Rex2的Pleckstrin同源结构域的结构与生化特性的表征及其PIP3调节机制
Jennifer N Cash,Prateek V Sharma,John J G Tesmer
Jennifer N Cash
P-Rex family Rho guanine-nucleotide exchange factors are important regulators of cell motility through their activation of a subset of small GTPases. Both P-Rex1 and P-Rex2 have also been implicated in the progression of certain cancers, in...
Systematized analysis of secondary structure dependence of key structural features of residues in soluble and membrane-bound proteins [0.03%]
可溶与膜结合蛋白质中氨基酸二级结构依赖性的重要结构特征的系统分析研究
Mohammed H Al Mughram,Noah B Herrington,Claudio Catalano et al.
Mohammed H Al Mughram et al.
Knowledge of three-dimensional protein structure is integral to most modern drug discovery efforts. Recent advancements have highlighted new techniques for 3D protein structure determination and, where structural data cannot be collected ex...
Cyclodextrins for structural and functional studies of mechanosensitive channels [0.03%]
环糊精在力敏感通道结构与功能研究中的应用
Yixiao Zhang,Gabriella Angiulli,Boris Martinac et al.
Yixiao Zhang et al.
Mechanosensitive (MS) channels that are activated by the 'force-from-lipids' (FFL) principle rest in the membrane in a closed state but open a transmembrane pore in response to changes in the transmembrane pressure profile. The molecular im...
Shirel Ben-Shimon,Daniel Stein,Raz Zarivach
Shirel Ben-Shimon
Biomineralization is the process of mineral formation by living organisms. One notable example of these organisms is magnetotactic bacteria (MTB). MTB are Gram-negative bacteria that can biomineralize iron into magnetic nanoparticles. This ...
The dorsal tergite cuticle of Helleria brevicornis: Ultrastructure, mineral distribution, calcite microstructure and texture [0.03%]
Helleria brevicornis背部背板表皮：显微结构、矿物分布、文石微观结构和织构
Bastian Seidl,Christian Reisecker,Frank Neues et al.
Bastian Seidl et al.
Among the terrestrial Crustacea, isopods have most successfully established themselves in a large variety of terrestrial habitats. As in most Crustacea, their cuticle consists of a hierarchically organised organic phase of chitin-protein fi...
The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a) [0.03%]
人类组蛋白赖氨酸N-甲基转移酶EHMT2(G9A)半胱氨酸丰富区域的结构
Keshia M Kerchner,Tung-Chung Mou,Yizhi Sun et al.
Keshia M Kerchner et al.
Euchromatic histone-lysine N-methyltransferase 1 (EHMT1; G9a-like protein; GLP) and euchromatic histone-lysine N-methyltransferase 2 (EHMT2; G9a) are protein lysine methyltransferases that regulate gene expression and are essential for deve...
Structural characterization of two solute-binding proteins for N,N'-diacetylchitobiose/ N,N',N''-triacetylchitotoriose of the gram-positive bacterium, Paenibacillus sp. str. FPU-7 [0.03%]
芽孢杆菌Paenibacillus sp. str. FPU-7的N，N'-二乙酰海藻双糖/N，N'，N''-三乙酰海藻三分糖结合蛋白结构研究
Takafumi Itoh,Misaki Yaguchi,Akari Nakaichi et al.
Takafumi Itoh et al.
The chitinolytic bacterium Paenibacillus sp. str. FPU-7 efficiently degrades chitin into oligosaccharides such as N-acetyl-D-glucosamine (GlcNAc) and disaccharides (GlcNAc)2 through multiple secretory chitinases. Transport of these oligosac...
Crystal structure of a homotrimeric verrucomicrobial exo- β-1,4-mannosidase active in the hindgut of the wood-feeding termite Reticulitermes flavipes [0.03%]
一种参与木栖黄粉虫Reticulitermes flavipes 后肠中作用的同三聚体 verrucomicrobial 外-β-1,4-半乳糖苷酶的晶体结构
Dayanand C Kalyani,Tom Reichenbach,Markus M Keskitalo et al.
Dayanand C Kalyani et al.
The termite Reticulitermes flavipes causes extensive damage due to the high efficiency and broad specificity of the ligno- and hemicellulolytic enzyme systems produced by its symbionts. Thus, the R. flavipes gut microbiome is expected to co...
Experimental evaluation of super-resolution imaging and magnification choice in single-particle cryo-EM [0.03%]
单颗粒冷冻电镜中超分辨率成像和放大倍率选择的实验评估
J Ryan Feathers,Katherine A Spoth,J Christopher Fromme
J Ryan Feathers
The resolution of cryo-EM reconstructions is fundamentally limited by the Nyquist frequency, which is half the sampling frequency of the detector and depends upon the magnification used. In principle, super-resolution imaging should enable ...