The parabasal filaments of Trichomonas vaginalis: A new filament and observations using 0.8 nm-resolution scanning electron microscopy [0.03%]
阴道毛滴虫的鞭毛基纤维：一种新的纤维以及采用分辨率0.8nm的扫描电子显微镜的观察结果
Sharmila Fiama das Neves Ortiz,Raphael Verdan,Gustavo Miranda Rocha et al.
Sharmila Fiama das Neves Ortiz et al.
Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common nonviral sexually transmitted infection worldwide, with an estimated 260 million new cases annually. T. vaginalis contains organelles common to all eukaryotic c...
Lauren Stover,Hanieh Bahramimoghaddam,Lie Wang et al.
Lauren Stover et al.
Aquaporin Z (AqpZ), a bacterial water channel, forms a tetrameric complex and, like many other membrane proteins, activity is regulated by lipids. Various methods have been developed to facilitate structure determination of membrane protein...
Structure of biomimetic casein micelles: Critical tests of the hydrophobic colloid and multivalent-binding models using recombinant deuterated and phosphorylated β-casein [0.03%]
生物仿生酪蛋白胶束的结构：使用重组氘化和磷酸化β-酪蛋白对疏水性胶体和多价结合模型进行关键测试
Jared K Raynes,Jitendra Mata,Karyn L Wilde et al.
Jared K Raynes et al.
Milk contains high concentrations of amyloidogenic casein proteins and is supersaturated with respect to crystalline calcium phosphates such as apatite. Nevertheless, the mammary gland normally remains unmineralized and free of amyloid. Unl...
Peptoid-based macrodiscs of variable lipid composition for structural studies of membrane proteins by oriented-sample solid-state NMR [0.03%]
基于肽类的巨环盘，可变脂质组成，用于定向固体状态NMR膜蛋白结构研究
Azamat R Galiakhmetov,Adit A Shah,Addison Lane et al.
Azamat R Galiakhmetov et al.
Solid-state Nuclear Magnetic Resonance (NMR) in combination with magnetically aligned discoidal lipid mimics allows for studying the conformations of membrane proteins in planar, lipid-rich bilayer environments and at the physiological temp...
NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750 [0.03%]
核磁共振结构验证了转录因子ZNF750同名的锌指区域
Antonio J Rua,Richard D Whitehead rd,Andrei T Alexandrescu
Antonio J Rua
ZNF750 is a nuclear transcription factor that activates skin differentiation and has tumor suppressor roles in several cancers. Unusually, ZNF750 has only a single zinc-finger (ZNF) domain, Z*, with an amino acid sequence that differs marke...
Cryo-EM of a heterogeneous biochemical fraction elucidates multiple protein complexes from a multicellular thermophilic eukaryote [0.03%]
低温电镜解析出多细胞嗜热真核生物的多种蛋白质复合物
Dmitry A Semchonok,Fotis L Kyrilis,Farzad Hamdi et al.
Dmitry A Semchonok et al.
Biomolecular complexes and their interactions govern cellular structure and function. Understanding their architecture is a prerequisite for dissecting the cell's inner workings, but their higher-order assembly is often transient and challe...
Discovery, characterization, and redesign of potent antimicrobial thanatin orthologs from Chinavia ubica and Murgantia histrionica targeting E. coli LptA [0.03%]
来自东亚中华稻蝗和红火蚁的高效抗菌肽thanatin同源物的发现、表征及重设计以针对大肠杆菌LptA
Kelly Huynh,Amanuel Kibrom,Bruce R Donald et al.
Kelly Huynh et al.
Podisus maculiventris thanatin has been reported as a potent antimicrobial peptide with antibacterial and antifungal activity. Its antibiotic activity has been most thoroughly characterized against E. coli and shown to interfere with multip...
Transformations between rotational and translational invariants formulated in reciprocal spaces [0.03%]
基于互易空间的转动不变量和平移不变量之间的转换关系式
Philip R Baldwin
Philip R Baldwin
Correlation functions play an important role in the theoretical underpinnings of many disparate areas of the physical sciences: in particular, scattering theory. More recently, they have become useful in the classification of objects in are...
Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier [0.03%]
流感病毒A型M2蛋白与抗病毒小分子氨苯吡唑相互作用动力学研究
Kumar Tekwani Movellan,Melanie Wegstroth,Kerstin Overkamp et al.
Kumar Tekwani Movellan et al.
The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that pore binding did not occur in certain detergent micelle...
CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics [0.03%]
冷冻电镜揭示了多酶复合物的寡聚异构体及组装机制
Jane K J Lee,Yun-Tao Liu,Jason J Hu et al.
Jane K J Lee et al.
Propionyl-CoA carboxylase (PCC) is a multienzyme complex consisting of up to six α-subunits and six β-subunits. Belonging to a metabolic pathway converging on the citric acid cycle, it is present in most forms of life and irregularities i...