Antiviral performance of graphene-based materials with emphasis on COVID-19: A review [0.03%]
基于石墨烯的材料抗病毒性能(重点针对COVID-19)的综述研究
Tahereh Seifi,Ali Reza Kamali
Tahereh Seifi
Coronavirus disease-2019 has been one of the most challenging global epidemics of modern times with a large number of casualties combined with economic hardships across the world. Considering that there is still no definitive cure for the r...
The controversial therapeutic journey of chloroquine and hydroxychloroquine in the battle against SARS-CoV-2: A comprehensive review [0.03%]
氯喹和羟氯喹对抗SARS-CoV-2争议性治疗之旅：全面回顾
Subham Das,Anu Kunnath Ramachandran,Sumit Raosaheb Birangal et al.
Subham Das et al.
Recently, the pandemic outbreak of a novel coronavirus, officially termed as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), indicated by a pulmonary infection in humans, has become one of the most significant challenges for p...
Network bioinformatics analysis provides insight into drug repurposing for COVID-19 [0.03%]
网络生物信息学分析为COVID-19再利用药物提供见解
Xu Li,Jinchao Yu,Zhiming Zhang et al.
Xu Li et al.
The COVID-19 disease caused by the SARS-CoV-2 virus is a health crisis worldwide. While developing novel drugs and vaccines is long, repurposing existing drugs against COVID-19 can yield treatments with known preclinical, pharmacokinetic, p...
New threatening of SARS-CoV-2 coinfection and strategies to fight the current pandemic [0.03%]
新型冠状病毒再感染的威胁及对抗当前大流行的策略
Nikky Goel,Razi Ahmad,Huma Fatima et al.
Nikky Goel et al.
Coronavirus disease (COVID-19) is a global pandemic. The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overloaded healthcare systems that need medication to be rapidly established, at least to ...
The new SARS-CoV-2 strain shows a stronger binding affinity to ACE2 due to N501Y mutant [0.03%]
由于N501Y突变新的SARS-CoV-2毒株表现出更强的与ACE2结合亲和力
Fedaa Ali,Amal Kasry,Muhamed Amin
Fedaa Ali
SARS-CoV-2 is a global challenge due to its ability to spread much faster than the SARS-CoV, which was attributed to the mutations in the receptor binding domain (RBD). These mutations enhanced the electrostatic interactions. Recently, a ne...
AI drug discovery screening for COVID-19 reveals zafirlukast as a repurposing candidate [0.03%]
用于COVID-19的AI药物发现筛选确定了色甘酸作为再定位候选药
Marcin Delijewski,Jacek Haneczok
Marcin Delijewski
Aims: Over the past few years, AI has been considered as potential important area for improving drug development and in the current urgent need to fight the global COVID-19 pandemic new technologies are even more in focus...
Gregory Upert,Anatol Luther,Daniel Obrecht et al.
Gregory Upert et al.
This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches...
Ernesto Estrada
Ernesto Estrada
We propose a new plausible mechanism by mean of which SARS-CoV-2 produces extrapulmonary damages in severe COVID-19 patients. The mechanism consist on the existence of vulnerable proteins (VPs), which are (i) mainly expressed outside the lu...
Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study [0.03%]
2020年5月北美社区医院重症监护病房中危重COVID-19患者维生素C和维生素D血清水平的初步研究
Cristian Arvinte,Maharaj Singh,Paul E Marik
Cristian Arvinte
Background: The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disea...
Karli Montague-Cardoso,Marzia Malcangio
Karli Montague-Cardoso
Chronic pain is a distressing yet poorly-treated condition that can arise as a result of diseases and injuries to the nervous system. The development of more efficacious therapies for chronic pain is essential and requires advances in our u...