Recent developments in receptor tyrosine kinase inhibitors: A promising mainstay in targeted cancer therapy [0.03%]
靶向癌症疗法中受体酪氨酸激酶抑制剂的新进展
Rahul Kumar,Harsh Goel,Raghu Solanki et al.
Rahul Kumar et al.
During the past two decades, significant advances have been made in the discovery and development of targeted inhibitors aimed at improving the survival rates of cancer patients. Among the multitude of potential therapeutic targets identifi...
Erica Seigneur,Luis de Lecea
Erica Seigneur
Twenty-two years after their discovery, the hypocretins (Hcrts), also known as orexins, are two of the most studied peptidergic systems, involved in myriad physiological systems that range from sleep, arousal, motivation, homeostatic regula...
Halle Lutz,Shiqi Hu,Phuong-Uyen Dinh et al.
Halle Lutz et al.
For over a century, researchers have focused on how to optimize drug delivery. Systemic administration means that the drug becomes dilute and has the potential to diffuse to all tissues, which is only until the immune system steps in and ra...
Yazheng Wang,Dandan Guo,Rebecca Winkler et al.
Yazheng Wang et al.
Background: Glucocorticoids (GCs) are widely used in the treatment of inflammatory liver diseases and sepsis, but GC's various side effects on extrahepatic tissues limit their clinical benefits. Liver-targeting GC therapy...
Repurposing of drugs for combined treatment of COVID-19 cytokine storm using machine learning [0.03%]
利用机器学习等方法对已上市药物进行重新评估以联合治疗COVID-19的细胞因子风暴
Maanaskumar R Gantla,Igor F Tsigelny,Valentina L Kouznetsova
Maanaskumar R Gantla
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) induced cytokine storm is the major cause of COVID-19 related deaths. Patients have been treated with drugs that work by inhibiting a specific protein partly responsible for the...
Deciphering antiviral efficacy of malaria box compounds against malaria exacerbating viral pathogens- Epstein Barr virus and SARS-CoV-2, an in silico study [0.03%]
解析疟疾框化合物对加重疟疾的病毒病原体-Epstein-Barr病毒和SARS-CoV-2的抗病毒功效，一项基于计算机的研究
Omkar Indari,Ajit Kumar Singh,Deeksha Tiwari et al.
Omkar Indari et al.
In malaria endemic countries, coinfections and cotransmissions of different viral pathogens are widely reported. Prior studies have shown that malaria can trigger the Epstein-Barr virus (EBV) reactivation in the body. Besides, the altered i...
Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19 [0.03%]
脂质体包裹氯膦酸介导致病性巨噬细胞和小胶质细胞的消除：缓解COVID-19细胞因子风暴的潜在药理学方案
Sowbarnika Ravichandran,Nivethitha Manickam,Mahesh Kandasamy
Sowbarnika Ravichandran
The emergence of new SARS-CoV-2 variants continues to pose an enormous public health concern. The SARS-CoV-2 infection disrupted host immune response accounting for cytokine storm has been linked to multiorgan failure and mortality in a sig...
Praveen Prathapan
Praveen Prathapan
While antimicrobial drug development has historically mitigated infectious diseases that are known, COVID-19 revealed a dearth of 'in-advance' therapeutics suitable for infections by pathogens that have not yet emerged. Such drugs must exhi...
The Delta Variant Mutations in the Receptor Binding Domain of SARS-CoV-2 Show Enhanced Electrostatic Interactions with the ACE2 [0.03%]
德尔塔新冠病毒受体结合域变异体与ACE2的静电相互作用增强
Shaimaa S Goher,Fedaa Ali,Muhamed Amin
Shaimaa S Goher
Mutations in the receptor binding domain (RBD) in SARS-CoV-2 are shown to enhance its replication, transmissibility, and binding to host cells. Recently, a new strain is reported in India that includes a mutation (T478K, and L452R) in the R...
Shurong Zhou,Wenjie Chen,Janet Cole et al.
Shurong Zhou et al.
Cancer immunotherapy has shown great potential as witnessed by an increasing number of immuno-oncology drug approvals in the past few years. Meanwhile, the field of nucleic acid therapeutics has made significant advancement. Nucleic acid th...