Enhanced endosomal escape for nanoparticle-enabled co-delivery of doxorubicin and siRNA to overcome multidrug resistance [0.03%]
增强纳米药物的溶酶体逃逸以联合递送多西他赛和siRNA克服耐药性
Jin Zhai,Allison Surian,Trystin Cote et al.
Jin Zhai et al.
Although co-delivery of small-molecule drugs and siRNAs is a promising platform strategy for combination therapy, current delivery systems fail to achieve efficient endosomal escape, limiting cytosolic siRNA bioavailability and therapeutic ...
Peripheral nerve sheath tumors-on-a-chip: Next-generation platforms for mechanistic and therapeutic studies [0.03%]
外周神经鞘肿瘤芯片：下一代机制和治疗研究平台
William H Delaney,Sara A Faulkner,Wilbur A Lam et al.
William H Delaney et al.
Recapitulation of the complex nerve-tumor-immune microenvironment is critical for understanding Peripheral Nerve Sheath Tumors (PNSTs). Conventional in vitro models and animal systems often struggle to model crucial intercellular and inter-...
Microneedle Strategies for Diabetic Wound Management: A Comprehensive Review of Materials, Mechanisms, and Therapeutic Outcomes [0.03%]
用于糖尿病伤口管理的微针策略：材料、机制和治疗效果的全面回顾
Kaustubh Naik,Kanhaiya Singh
Kaustubh Naik
Chronic diabetic wounds are one of the most challenging clinical problems because of poor angiogenesis, prolonged inflammation, and retarded tissue repair. Conventional wound dressing does not provide localised and continuous treatment, fre...
Inkjet-printed morphogenesis of tumor-stroma interface using bi-cellular bioinks of collagen-poly(N-isopropyl acrylamide-co-methyl methacrylate) mixture [0.03%]
基于胶原蛋白-聚[N-异丙基丙烯酰胺共甲基丙烯酸甲酯]双细胞生物墨水的肿瘤间质界面的 inkjet 打印式形态发生
Cih Cheng,Naomi Deneke,Hye-Ran Moon et al.
Cih Cheng et al.
Recent advances in biomaterials and 3D printing/culture methods enable various tissue-engineered tumor models. However, it is still challenging to achieve native tumor-like characteristics due to lower cell density than native tissues and p...
Resolving protein-mineral interfacial interactions during in vitro mineralization by atom probe tomography [0.03%]
应用原子探针断层扫描解析体外矿化过程中蛋白-矿物质界面相互作用
Sandra D Taylor,Jinhui Tao,Yongsoon Shin et al.
Sandra D Taylor et al.
Organic macromolecules exert remarkable control over the nucleation and growth of inorganic crystallites during (bio)mineralization, as exemplified during enamel formation where the protein amelogenin regulates the formation of hydroxyapati...
Calcium carbonate vaterite particles for drug delivery: Advances and challenges [0.03%]
用于药物输送的钙碳酸盐瓦泰石颗粒：进展与挑战
Daria B Trushina,Tatiana N Borodina,Sergei Belyakov et al.
Daria B Trushina et al.
The recent successful application of lipid-based nanoparticles as delivery vehicles in COVID-19 vaccines demonstrated the superior potential of nanoparticle-based technology for targeted drug delivery in biomedicine. Among novel, rapidly ad...
Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity [0.03%]
通过抑制与衰老相关的基因来利用蚕丝蛋白进行人体尿液干细胞的长期三维培养及其在慢性线粒体毒性评估中的潜在应用
Huifen Ding,Sunil George,Xiaoyan Iris Leng et al.
Huifen Ding et al.
Despite being widely applied in drug development, existing in vitro 2D cell-based models are not suitable to assess chronic mitochondrial toxicity. A novel in vitro assay system mimicking in vivo microenvironment for this purpose is urgentl...
Effective antiviral coatings for deactivating SARS-CoV-2 virus on N95 respirator masks or filters [0.03%]
有效的抗病毒涂层可灭活N95口罩或滤膜上的SARS-CoV-2病毒
Mariappan Parans Paranthaman,Nathan Peroutka-Bigus,Kristina R Larsen et al.
Mariappan Parans Paranthaman et al.
The application of antiviral coatings to masks and respirators is a potential mitigating step toward reducing viral transmission during the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic. The use of appropriate masks,...
Danwei Zhang,Solco S Faye Duran,Wei Yang Samuel Lim et al.
Danwei Zhang et al.
SARS-CoV-2 presence in wastewater has been reported in several studies and has received widespread attention among the Wastewater-based epidemiology (WBE) community. Such studies can potentially be used as a proxy for early warning of poten...
Potentialities of graphene and its allied derivatives to combat against SARS-CoV-2 infection [0.03%]
石墨烯及其衍生物对抗SARS-CoV-2感染的潜力
Ayesha Hashmi,Vanya Nayak,Kshitij Rb Singh et al.
Ayesha Hashmi et al.
Graphene is a two-dimensional material with sp2 hybridization that has found its broad-spectrum potentialities in various domains like electronics, robotics, aeronautics, etc.; it has recently gained its utilities in the biomedical domain. ...