Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing [0.03%]
基于多孔硅的工程化双驱动促血管生成nanozyme用于烧伤感染创面愈合的协同加速作用
Wei Duan,Yue Gao,Ruru Xu et al.
Wei Duan et al.
The high mortality risk of burn infected wounds has dictated the clinical need for the development of new biomaterials that can regulate multiple aspects of the healing process in a high-quality manner. Although nanozymes have made progress...
Surface prereacted glass-ionomer particles incorporated into resin composites promote biocompatibility for restoration of subgingival dental defects [0.03%]
表面预反应的玻璃离子小球嵌入树脂复合材料促进牙龈下牙齿缺陷修复的生物相容性
Yueyi Yang,Jing Huang,Xuchen Hu et al.
Yueyi Yang et al.
Subgingival dental defects are common in clinical practice among patients with deep dental caries and dental fractures. These defects commonly accompany lesions involving marginal alveolar bone loss and gingival recession, and their clinica...
Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres [0.03%]
载有吲哚菁绿的多孔PLGA微球用于缺血性卒中的双模态超声和近红外二区荧光同位素成像研究
Ziyue Li,Yu Qiang,Dongli Chen et al.
Ziyue Li et al.
Ischemic stroke, resulting from the obstruction of blood flow to the brain, remains a leading cause of morbidity and mortality worldwide. Traditional imaging modalities, such as magnetic resonance imaging and computed tomography, while effe...
pH-responsive molybdenum disulphide composite nanomaterials for skin wound healing using "ROS leveraging" synergistic immunomodulation [0.03%]
利用“ROS杠杆”协同免疫调节的皮肤伤口愈合的pH响应二硫化钼复合纳米材料
Zhen Yang,Jiaqian You,Shaobo Zhai et al.
Zhen Yang et al.
With the increasing prevalence of drug-resistant bacterial infections, wound bacterial infections have evolved into an escalating medical problem that poses a threat to the individual health as well as global public health. Traditional drug...
Ziyu Chen,Hao Zhang,Jingtao Huang et al.
Ziyu Chen et al.
Articular cartilage, composed of chondrocytes within a dynamic viscoelastic matrix, has limited self-repair capacity, posing a significant challenge for regeneration. Constructing high-fidelity cartilage organoids through three-dimensional ...
Injectable hydrogel regulates immune infiltration through physical and chemical synergy in the treatment of steroid-induced osteonecrosis of the femoral head [0.03%]
可通过物理和化学协同作用调节免疫浸润的可注射型水凝胶在治疗糖皮质激素诱发的股骨头坏死中的应用研究
Zherui Fu,Yiwen Xu,Fangqi Xu et al.
Zherui Fu et al.
The incidence of steroid-induced osteonecrosis of the femoral head (SONFH) is increasing annually; however, the underlying pathological mechanism remains unclear, which is an obstacle to its effective treatment. The negative effect of immun...
Janus adhesive bio-patches with targeted drug delivery enabled anti-bacteria and pro-angiogenesis for dura mater repair [0.03%]
具备定向给药抗菌促血管生成功能的 Janus 水凝胶粘性生物补片用于硬脑膜修复
Yirizhati Aili,Pengfei Wei,Xueqiao Yu et al.
Yirizhati Aili et al.
Dural injuries often result in severe complications such as cerebrospinal fluid (CSF) leakage, intracranial infections, and brain herniation, which significantly impact patient recovery and quality of life. Conventional dural repair materia...
Epsilon-polylysine microneedle potentiating MXene-mediated photothermal ablation for combating antibiotic-resistant bacterial infections [0.03%]
ε-聚赖氨酸微针促进MXene介导的光热消融联合治疗抗生素耐药细菌感染
Dongyi Xian,Rui Luo,Qiaoni Lin et al.
Dongyi Xian et al.
Antimicrobial peptides show promise in enhancing photothermal therapy, but their application is often limited by the challenge of constructing a delivery system that balances efficacy and safety. Our research demonstrated that the bacterici...
Curcumin-loaded bioadhesive silk fibroin microsphere improves islet transplantation by mitigating oxidative stress and inhibiting apoptosis [0.03%]
姜黄素负载生物黏附丝素微球通过减轻氧化应激和抑制凋亡改善胰岛移植
Chunhui Yang,Runjie Yu,Ying Zhang et al.
Chunhui Yang et al.
Islet transplantation, a form of cell therapy involving the injection of healthy islet cells into the recipient's body for curative treatment of T1DM, often fails due to oxidative stress and inflammatory damage experienced by the transplant...
Supramolecular peptide hydrogel epitope vaccine functionalized with CAR-T cells for the treatment of solid tumors [0.03%]
用于治疗实体瘤的载有CAR-T细胞的超分子肽水凝胶表位疫苗
Pengxiang Yang,Xiaomin Yao,Xue Tian et al.
Pengxiang Yang et al.
Chimeric antigen receptor T-cell (CAR-T) therapy, which benefits from the perfect combination of gene editing techniques and antibody engineering, has shown outstanding clinical efficacy in hematological malignancies. Solid tumors present t...