Thibault Cauwenbergh,Steven Ballet,Charlotte Martin
Thibault Cauwenbergh
Efficacy of therapeutic drugs is oftentimes limited in time by their low metabolic stability and rapid clearance mechanisms. Peptide hydrogels have been used for the physical encapsulation of a vast number of drugs in the treatment of many ...
3D printed biodegradable hydrogel-based multichannel nerve conduits mimicking peripheral nerve fascicules [0.03%]
仿生外周神经束的多通道神经导管的生物可降解水凝胶基材料的三维打印技术研究
Woo-Youl Maeng,Yerim Lee,Szu-Han Chen et al.
Woo-Youl Maeng et al.
Treating peripheral nerve injury (PNI) is a prevalent clinical challenge. The improper dispersion of regenerating axons makes it difficult to develop nerve guidance conduits (NGCs) for treating PNI. The multichannel NGCs, designed to mimic ...
Thermosensitive injectable in situ forming hydrogel incorporating anti-oxidative stress and anti-inflammatory nanoparticles for vital pulp therapy of pulpitis [0.03%]
一种负载抗氧化应激及抗炎纳米颗粒的热致响应原位成型水凝胶在牙髓炎活髓治疗中的应用研究
Lixin Zhang,Xianling Ning,Jingyi Cui et al.
Lixin Zhang et al.
Vital pulp therapy is critically important for the long-term preservation of teeth with pulpitis. However, the anti-inflammatory effects of pulp-capping materials used in clinics remain unsatisfactory. Pulpitis is tightly connected with oxi...
Cardioprotective effects of hUCMSCs-Exosi-EGR1 MN patch in MI/RI by modulating oxidative stress and mitophagy [0.03%]
人脐带源间充质干细胞外泌体衍生的EGR1基因工程microRNA调控氧化应激和线粒体自噬对心肌梗死和缺血再灌注损伤的心脏保护作用研究
Chen Huang,Xun Zhang,Shi-Xiong Wu et al.
Chen Huang et al.
In an effort to address the detrimental effects of myocardial ischemia/reperfusion injury (MI/RI), this study introduces a novel therapeutic strategy that involves a microneedle (MN) patch loaded with exosomes derived from human umbilical c...
Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis [0.03%]
工程化外泌体靶向抑制烟雾相关骨质疏松性骨丢失的骨髓间充干细胞铁死亡
Yao Wang,Lin Sun,Zhenglin Dong et al.
Yao Wang et al.
Smoking-related osteoporosis (SROP) is characterized by reduced bone mass, primarily due to the accumulation of tobacco-derived toxins. This study demonstrates the activation of ferroptosis and reactive oxygen species (ROS)-related pathways...
Advancements in functional tetrahedral DNA nanostructures for multi-biomarker biosensing: Applications in disease diagnosis, food safety, and environmental monitoring [0.03%]
用于多生物标志物检测的四面体DNA纳米结构研究进展：疾病诊断、食品安全和环境监测中的应用
Yun Qiu,Yixing Qiu,Wenchao Zhou et al.
Yun Qiu et al.
Deoxyribonucleic acid (DNA) offers the fundamental building blocks for the precisely controlled assemblies due to its inherent self-assembly and programmability. The tetrahedral DNA nanostructure (TDN) stands out as a widely utilized nanost...
Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery [0.03%]
用于创建局部和定时治疗的注射型透明质酸基水凝胶生态位疗法
Veronica Torresan,Alessandro Gandin,Paolo Contessotto et al.
Veronica Torresan et al.
The use of hydrogel-based niches for therapy delivery enables the concentration of active components and cells in a targeted area. This approach enhances efficacy while minimizing systemic side effects by spatially controlling the release o...
Photochemical corneal cross-linking: Evaluating the potential of a hand-held biopen [0.03%]
手持式生物笔进行的化学交联术治疗白内障：评估其潜在作用
Nadina Usseglio,Julia López de Andrés,Juan Antonio Marchal et al.
Nadina Usseglio et al.
The generation of organized 3D tissue constructs that combines cells and photo-crosslinkable biomaterials has been demonstrated using a variety of 3D bioprinting technologies. These technologies have inspired the application for "in situ" b...
A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines [0.03%]
一种pH响应的PROTAC基纳米系统触发肿瘤特异性铁死亡以构建原位肿瘤疫苗
Linghong Huang,Xinyuan Sun,Qinhua Zuo et al.
Linghong Huang et al.
Bromodomain-containing protein 4 (BRD4) is a key protein that drives the development of malignant melanoma and is closely associated with the ferroptosis signaling pathway. Degradation of BRD4 can downregulate the expression of ferroptosis-...
Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair [0.03%]
一种用于缓解神经炎症和促进脊髓损伤修复的多功能纳米凝胶递药系统
Penghui Wang,Zaifeng Chen,Ping Li et al.
Penghui Wang et al.
Spinal cord injury (SCI) is significantly hampered by an inflammatory microenvironment, prompting continued efforts in drug development to address inflammation. Research shows that quercetin (Que) exhibits excellent performance in reducing ...