3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration [0.03%]
用于骨溶解干预和骨再生的掺镓3D打印支架
Hanrui Xi,Xihao Jiang,Shilang Xiong et al.
Hanrui Xi et al.
Exacerbation of osteolysis in osteoporotic bone defects presents a significant challenge for implant-based treatments. This underscores the urgent need to develop implants that actively mitigate osteolysis while simultaneously promoting bon...
Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition [0.03%]
使用PAMAM树枝状大分子稳定金属掺杂的氧化镁纳米颗粒以提高对α-淀粉酶抑制的作用
Jaison Jeevanandam,Mara Gonçalves,Rita Castro et al.
Jaison Jeevanandam et al.
The present study aimed to synthesize metal-doped magnesium oxide (MgO) nanoparticles to drastically reduce polydispersity and stabilize them with generation 5 of poly(amidoamine) (G5 PAMAM) dendrimers to assess their antidiabetic propertie...
Functional poly(ether-ketone-ketone) composite scaffold with enhanced cell-material interaction, anti-inflammatory and osteogenesis for facilitating osteointegration and bone regeneration [0.03%]
具有增强的细胞-材料相互作用，抗炎和成骨功能的聚醚酮酮复合支架，有利于骨整合和骨再生
Qianwen Yang,Anbei Chen,Xin Zhang et al.
Qianwen Yang et al.
Bone defects resulting from trauma or disease remain a significant challenge in clinical practice, often requiring prolonged treatment. Poly(ether-ketone-ketone) (PEKK) is a commonly used implant material due to its excellent biocompatibili...
Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions [0.03%]
开创性地将离子液体用于神经舒缓：胶原蛋白肽的增强经皮递送及其协同抗衰老功能
Mi Wang,Zhenyuan Wang,Tianqi Liu et al.
Mi Wang et al.
Facial wrinkles include static and dynamic lines formed through different mechanisms and require diverse treatment approaches. Peptides perform well in anti-aging and wrinkle removal but exhibit poor transdermal efficiency. In this work, a ...
Multifunctional liposome boosts glioma ferroptosis and immunotherapy through reinforcement of chemo-dynamic therapy strategy [0.03%]
多功能脂质体通过强化化疗-动态治疗策略促进胶质瘤的铁死亡和免疫疗法
Hongwu Chen,Jiehao Huang,Huaiming Wang et al.
Hongwu Chen et al.
Glioma remains significant challenging to completely cure by the conventional surgical resection because of its high infiltrative growth properties. Recently, emerging immunotherapy has achieved remarkable success in treating various cancer...
Natural collagen scaffold with intrinsic piezoelectricity for enhanced bone regeneration [0.03%]
具有固有压电性的天然胶原支架可促进骨再生
Jing Han,Zhao Li,Jing Du et al.
Jing Han et al.
Materials-mediated piezoelectric signals have been widely applied in bone regeneration. Collagen is the most abundant protein in the human body, and native collagen with complete tertiary structure shows efficient piezoelectricity. However,...
Constructing a 3D co-culture in vitro synovial tissue model for rheumatoid arthritis research [0.03%]
用于类风湿关节炎研究的3D共培养体外滑膜组织模型的构建
Xiaocheng Wang,Jiaxin He,Qiang Zhang et al.
Xiaocheng Wang et al.
The development and exploration of highly effective drugs for rheumatoid arthritis remains an urgent necessity. However, current disease research models are no longer sufficient to meet the rapid development of high-throughput drug screenin...
Enhancing auricular reconstruction: A biomimetic scaffold with 3D-printed multiscale porous structure utilizing chondrogenic activity ink [0.03%]
增强耳部重建：利用成软骨活性墨水进行3D打印多尺度多孔结构的仿生支架
Yueying Kong,Zijing Lu,Jianan Zhan et al.
Yueying Kong et al.
Auricular defects are highly prevalent and have a significant impact on the physical and mental well-being of patients. However, due to the intricate anatomy of the auricle, achieving personalized and precise reconstruction poses a major ch...
Adhesive micro-liquid for efficient removal of bacterial biofilm infection [0.03%]
用于有效去除细菌生物膜感染的粘性微液滴
Ying Wang,Zhibang Li,Lingli Ji et al.
Ying Wang et al.
Bacteria are common infectious pathogens that can cause invasive and potentially life-threatening infections. Ionic liquids have emerged as a novel class of alternatives to antibiotics, however their inherent hydrophobicity and immiscible i...
Brain neurons internalise polymeric micron-sized capsules: Insights from in vitro and in vivo studies [0.03%]
从体外和体内研究中获得的关于大脑神经元摄取聚合物微米大小胶囊的见解
Olga Kopach,Olga A Sindeeva,Kaiyu Zheng et al.
Olga Kopach et al.
Nanoengineered encapsulation presents a promising strategy for targeted drug delivery to specific regions in the body. While polyelectrolyte-based biodegradable microcapsules can achieve highly localised drug release in tissues and cell cul...