The anti-depression effect and mechanism of harmonious rosemary essential oil and its application in microcapsules [0.03%]
和合薰衣草精油的抗抑郁效果及其机制与微胶囊化应用研究
Yunwei Niu,Liyang Xu,Mengdong Qiao et al.
Yunwei Niu et al.
Depression imposes a heavy burden on patients and society, and current antidepressants often cause side effects such as dryness in the mouth and constipation. The explorations about aromatic plant essential oils provide a new method for the...
Cyclooxygenase-2/prostaglandin E2 inhibition remodulated photodynamic therapy-associated immunosuppression for enhanced cancer immunotherapy [0.03%]
环氧化酶-2/前列腺素E2抑制改变光动力疗法相关的免疫抑制以提高癌症免疫治疗效果
Tao Xu,Kehan Liu,Shuqi Mi et al.
Tao Xu et al.
Low immunogenicity and immunosuppressive tumor microenvironment (TME) are two pivotal factors restricting tumor immunotherapy. Photodynamic therapy (PDT) directly destroys cancer cells by producing reactive oxygen species (ROS), and enhance...
Macrophage-related inflammatory responses to degradation products of biodegradable molybdenum implants [0.03%]
巨噬细胞对可降解钼植入物的降解产物的相关炎症反应
Danyang Liu,Jiahao Chen,Jiannan Zhou et al.
Danyang Liu et al.
Metallic molybdenum (Mo) has been increasingly recognized as a potential biodegradable metal for biomedical implants. However, the macrophage-mediated inflammatory responses to Mo-based implants remain underexplored. This study examined the...
Exosome-loaded tannic acid-thioctic acid hydrogel enhances wound healing in coagulation disorders [0.03%]
载有单宁酸-硫辛酸水凝胶的外泌体促进凝血障碍中的伤口愈合
Yuesheng Tu,Weixin Zheng,Zichu Ding et al.
Yuesheng Tu et al.
Hemophilia poses distinct challenges to wound healing, primarily due to uncontrolled bleeding and delayed tissue repair. This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow ...
Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition [0.03%]
用于靶向热休克蛋白90抑制的增强型近红外二区响应金纳米双锥结构颗粒
Zhenying Diao,Youcheng Liang,Yong Liu et al.
Zhenying Diao et al.
Blockade of heat shock protein 90 (HSP90) expression in multimodal synergistic therapy has a great prospect for cancer treatment. Nanomaterials combined with bioinformatic analysis provides accurate guidance for the design of anti-HSP90 nan...
Nanomaterials for targeted therapy of kidney diseases: Strategies and advances [0.03%]
用于肾脏疾病靶向治疗的纳米材料：策略与进展
Zhiwen Wang,Chun Zhang
Zhiwen Wang
The treatment and management of kidney diseases pose a significant global burden. Due to the presence of blood circulation barriers and glomerular filtration barriers, drug therapy for kidney diseases faces challenges such as poor renal tar...
Multi-active phlorotannins boost antimicrobial peptide LL-37 to promote periodontal tissue regeneration in diabetic periodontitis [0.03%]
多活性焦甘酯类物质促进抗微生物肽LL-37以促进糖尿病牙周炎的牙周组织再生
Cancan Li,Luowen Du,Yingying Xiao et al.
Cancan Li et al.
The bidirectional correlation between diabetes and periodontitis positions the latter as the most prevalent complication of the former. Rehabilitation of the periodontal tissues damaged by diabetic periodontitis presents a significant clini...
Rongpeng Dong,Shuang Zheng,Xueliang Cheng
Rongpeng Dong
Spinal diseases and injuries are prevalent in clinical settings and impose a substantial burden on healthcare systems. Current treatments for spinal diseases are predominantly limited to surgical interventions, drug injections, and conserva...
Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury [0.03%]
仿生纳米囊通过溶栓和预防缺血再灌注损伤对不同缺血时间的皮肤瓣进行序贯治疗
Linzhong Yang,Yuanchen Liu,Cheng Tao et al.
Linzhong Yang et al.
Flap transplantation is a critical part of the recovery process for patients who have undergone tumor resection. However, the process of ischemia-reperfusion injury during flap transplantation and the resulting high-risk thrombotic microenv...
Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury [0.03%]
物理工程改造的细胞外囊泡靶向递送miR-21-5p以促进肾缺血再灌注损伤后的肾脏保护
Di Wu,Wenjie Ma,Liucheng Wang et al.
Di Wu et al.
Acute kidney injury (AKI) resulting from ischemia-reperfusion injury (IRI) is a common challenge in various clinical practices, yet effective therapies remain elusive. Endothelial injury plays a crucial role in the pathogenesis of renal IRI...