Lymph node-targeted delivery of Lonicera japonica thunb. polysaccharides for enhancing antitumor immunotherapy [0.03%]
忍冬提取多糖的淋巴结靶向投递及其对肿瘤免疫治疗的增强作用研究
Jiatong Zhang,Jintong Liu,Hong Zhang et al.
Jiatong Zhang et al.
Dendritic cells (DCs) are crucial for the initiation and regulation of innate and adaptive immunity. Their maturity and infiltration in the tumor largely determine the efficiency of antigen presentation, the CTL responses, and the prognosis...
A tumor-targeting black phosphorus-based nanoplatform for controlled chemo-photothermal therapy of breast cancer [0.03%]
用于控制乳腺癌化疗光热治疗的肿瘤靶向型基于黑磷纳米平台
Lin Yang,Ying Zhang,Jing Liu et al.
Lin Yang et al.
Combination therapy with high efficacy and precision shows great potential in breast cancer treatment. Herein, we developed a multifunctional nanocarrier (NBP@mSiO2-PEG-cRGD) for tumor-targeting chemo-photothermal therapy of breast cancer i...
Intranasal delivery of AEP inhibitor-loaded neuron-targeted liposome ameliorates radiation-induced brain injury [0.03%]
载AEP抑制剂的神经元靶向脂质体鼻内给药可减轻辐射诱导的脑损伤
Keman Liao,Yan Gao,Mengdan Cheng et al.
Keman Liao et al.
Acute exposure to high-dose radiation during head and neck tumors radiotherapy can result in radiation-induced brain injury (RIBI), characterized by neurocognitive deficits, dementia, and epilepsy. Asparagine endopeptidase (AEP), a cysteine...
Chitin nanocrystal-reinforced chitin/collagen composite hydrogels for annulus fibrosus repair after discectomy [0.03%]
用于椎间盘切除后纤维环修复的几丁质纳米晶体增强的几丁质/胶原复合水凝胶
Mingzhi Liu,Zhiyong Cui,Derong Xu et al.
Mingzhi Liu et al.
Discectomy is a widely utilized approach for alleviating disc herniation; however, effective repair of postoperative annulus fibrosus (AF) defects remains a significant challenge. This study introduces a hydrogel patch with enhanced mechani...
Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head [0.03%]
用于股骨头坏死个性化治疗的3D打印技术进展
Tingting Chen,Lincong Luo,Jiaying Li et al.
Tingting Chen et al.
Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly in orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on the innovative application ...
Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy [0.03%]
响应酶的维生素D基胶束用于紫杉醇控制输送及胰腺癌协同治疗
Diana Peixoto,João M Ravasco,Barbara Blanco-Fernandez et al.
Diana Peixoto et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most feared diseases worldwide owing to its poor prognosis, negligible therapeutic advances, and high mortality. Herein, multifunctional enzyme-responsive micelles for the controlle...
Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy [0.03%]
基于集成微流体的anti-BTN2A2凝胶液滴细胞制剂构建用于非侵入性肿瘤浸润淋巴细胞治疗
Yishen Tian,Jingxuan Li,Na Yang et al.
Yishen Tian et al.
Tumor infiltrating lymphocyte therapy (TIL therapy) is one of the effective treatments for solid tumors. However, certain periods or sites of solid tumors are not amenable to surgical resection. Meanwhile, the abundant and dense extracellul...
Nature-derived microneedles with metal-polyphenolic networks encapsulation for chronic soft tissue defects repair: Responding and remodeling the regenerative microenvironment [0.03%]
用于慢性软组织缺损修复的源自自然的微针：响应并重塑再生微环境中的金属多酚网络封装
Chengyang Zhu,Zun Fan,Zhijie Cheng et al.
Chengyang Zhu et al.
The treatment outcomes of traditional patches for chronic soft tissue defects (CSTDs) are unsatisfactory in clinical, owing to the lack of intrinsic bioactivities to orchestrate the intricate regenerative process. To tackle this deficiency,...
An immunoregulation PLGA/Chitosan aligned nanofibers with polydopamine coupling basic fibroblast growth factor and ROS scavenging for peripheral nerve regeneration [0.03%]
具有ROS清除和结合基本成纤维细胞生长因子的免疫调节型PLGA/壳聚糖取向纳米纤维用于外周神经再生
Xiaokun Chen,Jihai Xu,Feng Qin et al.
Xiaokun Chen et al.
The repair and functional recovery of long-segment peripheral nerve injuries are crucial in clinical settings. Nerve conduits are seen as promising alternatives to autologous nerve grafts, but their effectiveness is limited by the controlle...
Spinal cord injury repair based on drug and cell delivery: From remodeling microenvironment to relay connection formation [0.03%]
基于药物和细胞递送的脊髓损伤修复：从重塑微环境到中继连接形成
Wanrong Ma,Xing Li
Wanrong Ma
Spinal cord injury (SCI) presents a formidable challenge in clinical settings, resulting in sensory and motor function loss and imposing significant personal and societal burdens. However, owning to the adverse microenvironment and limited ...