Biomimetic mineralized DCPA/ anti-CD47 containing thermo-sensitive injectable hydrogel for bone-metastatic prostate cancer treatment [0.03%]
含有抗CD47的仿生矿化DCPA/热敏注射水凝胶在骨转移性前列腺癌治疗中的应用研究
Shenglong Tan,Qianqian Wang,Chunxiang Feng et al.
Shenglong Tan et al.
Strategies that leverage the phagocytic capabilities of M1 macrophages against tumor cells are currently being investigated for cancer treatment. However, the clinical application of these strategies is significantly hampered by the severe ...
An "EVs-in-ECM" mimicking system orchestrates transcription and translation of RUNX1 for in-situ cartilage regeneration [0.03%]
一种“内质网在细胞质基质中”模拟系统协调RUNX1的转录和翻译以实现原位软骨再生
Qi Cheng,Qianping Guo,Xiaoyu Zhang et al.
Qi Cheng et al.
The self-repair ability of articular cartilage is limited, which is one of the most difficult diseases to treat clinically. Kartogenin (KGN) induces chondrogenesis by regulating RUNX1 mRNA translation and the small molecule compound TD-1989...
Thermo-sensitive ε-polylysine-heparin-poloxamer hydrogel-encapsulated BMSCs promote endometrial regeneration [0.03%]
thermo敏感的ε-聚赖氨酸-肝素-泊洛沙姆水凝胶包封的骨髓间充质干细胞促进子宫内膜再生
Ruifang Han,Haiyi Zhou,Xingshan Liang et al.
Ruifang Han et al.
Endometrium plays a key role in embryo implantation and maintenance of pregnancy. However, to repair endometrial injury is still a challenge. In recent years, hydrogel materials have been widely used as effective support matrices to prevent...
Nano-adjuvant based on lipo-imiquimod self-assembly for enhanced foot-and-mouth disease virus vaccine immune responses via intradermal immunization [0.03%]
基于脂质伊莫喹模自组装的纳米佐剂通过皮肤内免疫提高口蹄疫疫苗免疫反应
Wenzhu Yin,Zeyu Xu,Fang Ma et al.
Wenzhu Yin et al.
Excellent adjuvants and proper immunization routes play pivotal roles in activating a robust immune response. Nano-adjuvants have the advantages of enhancing immunogenicity, targeting delivery, and improving stability to provide a new solut...
Mingwei Xu,He Liu,Jiaxin Zhang et al.
Mingwei Xu et al.
The regulation of bone metabolic microenvironment imbalances in diseases such as osteoporosis, bone defects, infections, and tumors remains a significant challenge in orthopedics. Therefore, it has become urgent to develop biomaterials with...
Photothermal-controlled microneedle for transdermal delivery of metal-phenolic nanozyme with staged multifunctions to accelerate healing of infected diabetic wounds [0.03%]
用于加速感染糖尿病伤口愈合的金属酚纳米酶透皮给药的光热控制微针
Dong Yan,Guoqi Cao,Yikai Gao et al.
Dong Yan et al.
Conventional wound dressings for infected diabetic wounds (IDWs) typically target only the wound surface, often neglecting the need for multifunctional therapies that address deeper tissue layers, resulting in less effective treatment outco...
Dual-Action flavonol carbonized polymer dots spray: Accelerating burn wound recovery through immune responses modulation and EMT induction [0.03%]
双效黄酮类碳化聚合物点喷雾：通过免疫反应调节和EMT诱导加速烧伤伤口恢复
Liuyi Du,Xu Zhang,Lei Huang et al.
Liuyi Du et al.
Effective immune homeostasis modulation and re-epithelialization promotion are crucial for accelerating burn wound healing. Cell migration is fundamental to re-epithelialization, with epithelial-mesenchymal transition (EMT) as a key mechani...
An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance [0.03%]
一种聚集诱导发光的溶酶体劫持剂：破坏溶酶体以增强光动力治疗效果和克服肿瘤治疗抗性
Hang Zou,Pingping Wang,Zhihao Bai et al.
Hang Zou et al.
Therapeutic resistance is a major challenge in clinical cancer theranostics, often leading to treatment failure and increased patient mortality. Breaking this therapeutic deadlock, enhancing the efficacy of clinical treatments, and ultimate...
Inhaled predatory bacteria-loaded large porous microspheres to eradicate drug-resistant Pseudomonas aeruginosa from the lung [0.03%]
用于根除肺部耐药绿脓杆菌的吸入型带掠食性细菌的大孔微球
Yan Liu,Wanmei Wang,Ruiteng Li et al.
Yan Liu et al.
The pneumonia caused by antimicrobial-resistant Gram-negative bacteria is an intractable clinical problem due to the lack of effective treatments. Inspired by the unique predatory bacterial ability of Bdellovibrio bacteriovorus, we here dev...
Siyao Chen,Tongxin Wang,Jiaqi Chen et al.
Siyao Chen et al.
Several diseases affect the female reproductive system, and both disease factors and treatments impact its integrity and function. Consequently, understanding the mechanisms of disease occurrence and exploring treatment methods are key rese...