Bioinformatics driven in gene targeting platform for gold anticancer strategy delivery [0.03%]
基于生物信息学的基因治疗载体递送金抗肿瘤策略平台
Can Jiang,Haixuan Wen,Jiabin Chen et al.
Can Jiang et al.
Owing to its high degree of malignancy and poor survival outcomes, triple-negative breast cancer (TNBC) is considered the most invasive subtype of breast cancer. In the realm of TNBC treatment, clinical practice continues to be predominantl...
Biomimetic selenium nanomedicine with homologous targeting enhances hepatocellular carcinoma therapy [0.03%]
同源靶向仿生硒纳米药物增强肝癌治疗效果
Fang Cui,Qi-Xin Huang,Zhuo Yu et al.
Fang Cui et al.
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with limited effective therapeutic options. While trace elements like selenium (Se)-based nanoparticles (SeNPs) show promising anti-tumor effects, their clinical application i...
Injectable tert-butylphenylacetic acid/acrylated β-cyclodextrin-based hydrogels for co-delivery of CAR-T cells and IL-15 in solid tumor therapy [0.03%]
用于固体瘤治疗的可注射 tert-丁基苯乙酸/丙烯酸化β-环糊精基水凝胶以共递送CAR-T细胞和IL-15
Yun-Cheng Zeng,Yi-Qun Sun,Xue-Qing Zhang et al.
Yun-Cheng Zeng et al.
Chimeric antigen receptor (CAR)-T cell therapy has shown great potential in treating hematologic malignancies, but its efficacy in solid tumors is limited by the immunosuppressive microenvironment and poor tumor infiltration. Hydrogels poss...
Mesenchymal stem cell-derived small extracellular vesicles-loaded GelMA microspheres enhance diabetic wound healing by promoting M2 macrophage polarization through p38 MAPK inhibition [0.03%]
间充质干细胞源性小细胞外囊泡载药明胶微球通过抑制p38MAPK促进M2型巨噬细胞极化以加速糖尿病足溃疡愈合
Weizhao Li,Jiajia Chen,Lu Yu et al.
Weizhao Li et al.
Diabetic foot ulcers (DFUs) represent a serious complication of diabetes, typically exhibiting persistent inflammation and impaired tissue repair. Although small extracellular vesicles derived from mesenchymal stem cells (MSC-sEVs) possess ...
Neuroprotective effects of cobalt oxide nanoparticles through mitigating oxidative stress and reactive glial responses in traumatic brain injury [0.03%]
四氧化三钴纳米颗粒通过减轻氧化应激和创伤性脑损伤中的反应性胶质细胞反应发挥神经保护作用
Xuecheng Qiu,Congxin Shen,Yanyan Li et al.
Xuecheng Qiu et al.
Traumatic brain injury (TBI) is a leading global cause of mortality and long-term neurological deficits. TBI involves primary mechanical damage and secondary injury processes, including oxidative stress and reactive glial responses. Oxidati...
Immunoregulatory electrospinning fiber mediates Macrophage energy metabolism reprogramming to promote burn wound healing [0.03%]
免疫调节静电纺丝纤维介导巨噬细胞能量代谢重编促进烧伤创面修复
Haoyang Wu,Qimeng Wu,Chen Liang et al.
Haoyang Wu et al.
Burn wound management posed substantial therapeutic challenges due to impaired macrophage polarization dynamics. Metabolic dysfunction in macrophages hindered the transition from glycolysis-driven M1 phenotype to oxidative phosphorylation (...
Microenvironment-responsive hydrogels for spatiotemporal delivery of epigallocatechin gallate and BMP-2 to promote osteoporotic bone defect repair [0.03%]
响应微环境的水凝胶以时空方式递送EGCG和BMP-2促进骨缺损修复
Peilun Xiao,Guang Shi,Zeyao Lu et al.
Peilun Xiao et al.
Regenerating osteoporotic bone defects is still a major challenge. Conventional bone tissue engineering materials often fail to achieve on-demand drug delivery. At the same time, the therapeutic logic of osteoporotic bone defects requires s...
Mechanical energy-charged navigating pump repair natural vascular scaffolds to reverse osteoporosis [0.03%]
机械能充电导航泵修复天然血管支架以逆转骨质疏松症
Fengkun Wang,Shuai Yang,Yanbin Zhu et al.
Fengkun Wang et al.
Bone vasculature plays a critical role in maintaining bone health. A reduction in mechanical loading-induced vascular deficiency plays a critical role in osteoporosis progression by disrupting the bone microenvironment and impairing interce...
Zaotang-inspired pull-folding approach to fabricate oriented multifunctional scaffolds for bone repair [0.03%]
受皂糖启发的拉折成型制备骨修复用取向多功能支架
Zongying Zhang,Huitao Qi,Fei Xuan et al.
Zongying Zhang et al.
Bone defects caused by trauma, tumors, or infections impose significant clinical challenges due to donor scarcity and complications in traditional grafting. Current scaffold fabrication techniques like electrospinning and 3D printing face l...
Near infrared II excitation conjugated polymers-based phototheranostic nanoplatform for hyperthermia-enhanced ferroptosis and immunotherapy [0.03%]
近红外II区激发的共轭聚合物光诊疗平台增强热致铁死亡和免疫治疗
Yingying Chen,Ying Sun,Yuning Qiu et al.
Yingying Chen et al.
Ferroptosis has the potential to induce immunogenic cell death (ICD) and remodel the immunosuppressive tumor microenvironment (TME). However, intracellular antioxidant glutathione (GSH) inhibits the efficacy of ferroptosis. Consequently, en...