Non-competing Trop2 nanobody-based radiotheranostics for precision imaging and therapy of pancreatic cancer [0.03%]
基于非竞争性Trop2纳米抗体的放射治疗精准影像和胰腺癌治疗
Shushan Ge,Jinyu Shi,Tao Xu et al.
Shushan Ge et al.
Pancreatic cancer remains one of the most lethal malignancies, marked by late-stage detection, resistance to conventional therapies, and dismal overall survival. The transmembrane glycoprotein trophoblast cell-surface antigen 2 (Trop2) is f...
Modular design for drug delivery across hierarchical gastrointestinal barriers: From materials to systems [0.03%]
从材料到系统：针对分层胃肠屏障的药物传输模块化设计
Yaxin Chen,Qingyun Yang,Jian Yang et al.
Yaxin Chen et al.
Drug delivery to the gastrointestinal (GI) tract necessitates overcoming multi-level physiological barriers from organ to cellular levels, which exhibit significant heterogeneity under pathological conditions. Conventional delivery strategi...
Multidimensional nano-ion composite hydrogel based on enzymatic blood glucose control, gas therapy and ion liquid permeation for repairing diabetic wounds [0.03%]
基于酶促血糖控制、气体治疗和离子液体渗透的多维度纳離子复合水凝胶促进糖尿病伤口修复研究
Jun Ren,Peng Chen,Chun Sun et al.
Jun Ren et al.
The multifactorial pathogenesis of diabetic foot ulcers (DFUs) poses significant challenges to effective clinical management. To address this complexity, we have developed a multi-functional ionic composite hydrogel designed to concurrently...
Spermine oxidase-DOX conjugates reshape tumor microenvironment via carbonyl stress to potentiate bladder cancer chemotherapy [0.03%]
spermidine氧化酶-多柔比星缀合物通过羰基压力重塑肿瘤微环境以增强膀胱癌化学治疗
Yingying Xu,Chengyang Zhao,Shuai Fu et al.
Yingying Xu et al.
The tumor's antioxidant defenses restrict the efficacy of standard therapies, resulting in compromised treatment responses and systemic tolerance. Conventional redox-disrupting strategies, designed to generate reactive oxygen species (ROS),...
MRI-guided diagnosis and dual-pathway neuroprotection in ischemic stroke via PDA-engineered apple exosome-like nanoparticles [0.03%]
基于PDA工程化苹果类外体纳米颗粒的磁共振引导缺血性脑卒中诊断与双通道神经保护研究
Ju Bai,Wei Liu,Zhiyuan Wang et al.
Ju Bai et al.
Ischemic stroke (IS) presents a formidable clinical challenge due to its complex pathophysiology, encompassing neuroinflammation and oxidative stress, alongside the lack of comprehensive diagnostic and therapeutic strategies. To address thi...
Engineered acetylcholinesterase-loaded dissolvable microneedles mitigate dermal toxicity by targeting trichlorfon binding and metabolic pathway modulation [0.03%]
工程化的乙酰胆碱酯酶可降解微针通过靶向特异绑定和代谢通路调节来缓解三氯苯酚的毒性作用
Shuoqi Jiang,Zi-Wei Zheng,Qiuya Gu et al.
Shuoqi Jiang et al.
Trichlorfon (TCF), a widely used organophosphorus pesticide for crop protection, poses severe dermal toxicity risks as it readily penetrates the epidermal barrier and metabolizes into the more toxic dichlorvos (DDVP), triggering neurotoxici...
Non-destructive debridement and tuneable ion release via magnesium abrasion and electro-dissolution promote bone regeneration and osseointegration of infected implants [0.03%]
利用镁磨料和电化学腐蚀进行非破坏性清创及释放可调离子以促进感染型种植体的骨再生及骨整合
Zhixiang Nie,Yasheng Sun,Ke Li et al.
Zhixiang Nie et al.
Infection of metallic implants remains a major clinical challenge, often leading to failure and the need for revision. One approach to the treatment of infection is by debridement to remove infected tissue and biofilm - unfortunately this d...
Mechanochemical and machine-intelligent design of programmable materials: From molecular interactions to macroscale functionality [0.03%]
从分子相互作用到宏观功能的机械化学和机器智能设计编程材料
Mitra Najafloo,Leila Naji,Christoph Eberl
Mitra Najafloo
Programmable materials are an emerging class of matter capable of dynamically altering their properties, structure, or function in response to external stimuli. While most research has treated chemical and mechanical responsiveness separate...
Tailoring virus-inspired nanoparticles for advanced drug and gene delivery [0.03%]
用于药物和基因输送的病毒纳米粒子及其仿制粒子的研究进展与未来挑战
Ruilin Zhou,Miao Xu,Xuting Zheng et al.
Ruilin Zhou et al.
Viruses, as naturally evolved gene delivery systems, exhibit exceptional efficiency in overcoming biological barriers, targeting specific cells, and inducing robust immune responses. Inspired by these characteristics, virus-mimicking nanoca...
Toward clinical translation: montmorillonite-enhanced Lactobacillus biofilm alleviates colitis by modulating the gut microbiota-bile acid axis [0.03%]
montmorillonite增强的乳酸菌菌膜通过调节肠道微生物群-胆汁酸轴缓解结肠炎向临床转化研究
Zhongyuan Wang,Feng Zhu,Jie Zhang et al.
Zhongyuan Wang et al.
Oral probiotics hold therapeutic potential for ulcerative colitis (UC), but their low bioavailability greatly limits clinical efficacy. Here, we designed a montmorillonite-Lactobacillus acidophilus biofilm (MLB) delivery strategy to enhance...