Recent advances and future directions in urinary system tissue engineering [0.03%]
泌尿系统组织工程的近期进展和未来展望
Jie Yuan,Di Suo,Penghui Li et al.
Jie Yuan et al.
Recent advancements in tissue engineering offer promising solutions for the repair and reconstruction of the urinary system, particularly in cases of urinary organ injuries. Historically, autologous tissue grafts and allografts have been th...
3D bioprinted piezoelectric hydrogel synergized with LIPUS to promote bone regeneration [0.03%]
结合压电水凝胶和LIPUS的3D生物打印促进骨再生
Meng Li,Xiantong Hu,Xiaofei Liu et al.
Meng Li et al.
Bone defects resulting from trauma, tumor resection, non-union of fractures, and infections present enormous challenges in treatment. Although three-dimensional (3D) bioprinting plays an important role in repairing bone tissues, the lack of...
An in vitro model for cardiac organoid production: The combined role of geometrical confinement and substrate stiffness [0.03%]
心脏类器官生产的体外模型：几何限制和基质刚度的共同作用
R Santoro,L Piacentini,C Vavassori et al.
R Santoro et al.
Induced pluripotent stem cells (iPSCs), carrying the patient's genetic background, open the path to advanced in vitro modeling. The feasibility of recapitulating complex pathophysiological scenarios depends on iPSC's ability to differentiat...
3D-printed CoSi/PCL composite scaffold with NIR-II photothermal ability and enhanced adipogenic activity for breast reconstruction after mastectomy [0.03%]
具有近红外二区光热性能及增强的脂肪形成活性的3D打印CoSi/PCL复合支架用于乳腺癌根治术后乳房重建
Jupei Zhang,Hangbin Xia,Xuerui Zhou et al.
Jupei Zhang et al.
Breast reconstruction after mastectomy aims to restore breast appearance and function. Current scaffolds often fail to meet the complex clinical demands of post-mastectomy breast reconstruction, which include personalized shaping, preventio...
Innovative 3D-printed porous tantalum cage with non-window design to accelerate spinal fusion: A proof-of-concept study [0.03%]
具有创新性的3D打印多孔钽金属 Cage（无窗口设计）可加速脊柱融合：原理验证研究
Hang Liang,Jingyao Tu,Bingjin Wang et al.
Hang Liang et al.
An interbody fusion cage is crucial in spine fusion procedures, serving to restore physiological vertebral alignment and reestablish spinal stability. However, conventional fusion cages often face challenges related to insufficient osteoint...
Hongxia Cheng,Juan Liao,Yuhan Ma et al.
Hongxia Cheng et al.
The application of Nanocarriers (NCs) provides a promising strategy to solve the problems faced by traditional chemotherapy drugs, like the imprecise delivery, poor bioavailability, high dose requirement, and the tendency to develop multidr...
Lymphoma-on-chip model reveals that lymph node stromal cells promote diffuse large B-cell lymphoma survival and migration [0.03%]
芯片淋巴瘤模型揭示了淋巴结基质细胞促进弥漫性大B细胞淋巴瘤的存活和迁移
Mohammad Jouybar,Aleksandra M Mikula,Nanouk Zuidmeer et al.
Mohammad Jouybar et al.
Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell non-Hodgkin lymphoma, often developing resistance to current treatments. Development and testing of new therapies is hampered by lack of good in vivo and in vitro mo...
A macrophage-like biomimetic nanoparticle with high-efficiency biofilm disruption and innate immunity activation for implant-related infection therapy [0.03%]
一种具有高效生物膜破坏和固有免疫激活的类巨噬细胞仿生纳米粒用于种植体相关感染治疗
Guoqing Wei,Tiantian Xiao,Yufeng Xi et al.
Guoqing Wei et al.
The innate immune system's inactivation and microbial biofilm-induced antibiotic resistance are the main causes of implant-associated infections (IAIs), which frequently result in implant surgical failure. Refractory recolonization is the c...
Functional hydrogels promote chronic infectious wound healing by re-rousing macrophage M1 and inducing bacterial copper-like death [0.03%]
功能水凝胶通过重新激发巨噬细胞M1和诱导细菌的铜类死亡来促进慢性感染伤口的愈合
Chao Xiang,Chaoyu Pu,XueMei Zhong et al.
Chao Xiang et al.
Traditional antibiotics are often ineffective against biofilm-associated infections, and biofilm-induced macrophage immune evasion directly halts the wound healing process. Disrupting biofilms and regulating macrophage immune functions are ...
PLGA/HA sustained-release system loaded with liraglutide for the treatment of diabetic periodontitis through inhibition of necroptosis [0.03%]
载利拉鲁肽的PLGA/HA缓释系统通过抑制坏死性凋亡治疗糖尿病牙周炎
Yunqing Pang,Lingyuan Kong,Yuanyuan Li et al.
Yunqing Pang et al.
Diabetes and periodontitis exhibit a bidirectional relationship, posing significant challenges for the treatment of periodontitis in patients with diabetes. Our previous studies showed that the hypoglycemic agent liraglutide (LIRA), togethe...