Treating critical bone defects by using core-shell biological scaffold to regulate Fibrosis-Osteogenic homeostasis [0.03%]
利用核心-壳层生物支架调控纤维化-成骨稳态治疗关键骨缺损
Yonghang Li,Wenming Li,Linfeng Li et al.
Yonghang Li et al.
Critical bone defects pose a significant challenge in the realm of bone defect repair. During the repair process, bone formation is crucial, as the occurrence of invasive tissue growth into the defect, known as fibrosis, is also a possibili...
Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: In vitro models and preclinical innovations [0.03%]
透明质酸作为开发生物功能性水凝胶的多功能构建块：体外模型和临床前创新
Noémie Petit,Yu-Yin Joanne Chang,Franz Acker Lobianco et al.
Noémie Petit et al.
Hyaluronic acid (HyA) is a non-sulphated linear polysaccharide found abundantly in the extracellular matrix, known for its biocompatibility and versatility in tissue engineering. Chemical modifications of HyA, including methacrylate, acryla...
Yixiao Dong,Shuyi Qian,Xuechun Wang et al.
Yixiao Dong et al.
The mechanical properties and physical confinement of the extracellular matrix (ECM) are crucial roles in regulating tumor growth and progression. Extensive efforts have been dedicated to replicating the physical characteristics of tumor ti...
Shangsi Chen,James J Yoo,Min Wang
Shangsi Chen
Uterine injuries, particularly damages to endometrium, are usually associated with abnormal menstruation, recurrent miscarriage, pregnancy complications, and infertility. Tissue engineering using cell-based, biomolecule-based, or biomateria...
Size-dependent interactions between calciprotein particles and vascular endothelium [0.03%]
钙蛋白颗粒与血管内皮之间的尺寸依赖性相互作用
Zeping Zhang,Xinyue Wang,Caihao Huang et al.
Zeping Zhang et al.
The underlying mechanisms governing the interactions between nanoparticles and vascular endothelial barrier remain largely unexplored, which is crucial for the optimal design of nanoparticles for clinical applications. In this study, the si...
Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment [0.03%]
装载Tβ4外泌体的止血和抗菌水凝胶可改善血管再生并调节巨噬细胞极化以治疗糖尿病伤口
Hua Yu,Bin Wang,Zihao Li et al.
Hua Yu et al.
Diabetic wounds often exhibit delayed healing due to compromised vascular function and intensified inflammation. In this study, we overexpressed Thymosin β4 (Tβ4) in Adipose-Derived Stem Cells (ADSCs) to produce Exosomes (Exos) rich in T...
Near-infrared light-responsive nanocomposite hydrogels loaded with epidermal growth factor for diabetic wound healing [0.03%]
负载表皮生长因子的近红外光响应纳米复合水凝胶在糖尿病伤口愈合中的应用
Li Miao,Xue Lu,Yaoyao Wei et al.
Li Miao et al.
In diabetic wounds, the presence of hyperglycemia is often accompanied by a persistent inflammatory response, oxidative stress damage, impaired angiogenesis and bacterial infections around the wound, resulting in impaired proliferation of d...
A metal-polyphenol network-based iron supplement with improved stability and reduced gastrointestinal toxicity for iron deficiency anemia therapy [0.03%]
用于治疗缺铁性贫血的稳定性和胃肠道毒性降低的基于金属多酚网络的补铁剂
Ying Yao,Yuanzheng Chen,Jie Fu et al.
Ying Yao et al.
Iron deficiency anemia (IDA) is a global health concern, particularly affecting women and children of reproductive age. Although oral iron supplements are the standard treatment for IDA, their bioavailability is often compromised by food in...
Multifunctional hydrogel loaded with 4-octyl itaconate and exosomes to induce bone regeneration for diabetic infected bone defect via Keap1-Nrf2 pathway [0.03%]
通过Keap1-Nrf2通路加载4-辛基衣康酸和外泌体的多功能水凝胶诱导糖尿病感染性骨缺损的成骨再生
Yizhou Wan,Qing Gao,Bing Ye et al.
Yizhou Wan et al.
Diabetic infected bone defect remains a great challenge in clinical practice, with delayed healing characterized by bacterial infection and cellular disfunction caused by oxidative stress. Hence, a novel self-healing multifunctional Ag@PEG-...
Novel therapeutic strategies and recent advances in gut microbiota synergy with nanotechnology for colorectal cancer treatment [0.03%]
肠道菌群与纳米技术协同治疗结直肠癌的新疗法及最近进展
Qinghe Han,Jie Li,Zhuo Li et al.
Qinghe Han et al.
Over the last two decades, molecular biology advances have revealed the gut microbiota's active and crucial role in colorectal cancer (CRC) pathogenesis and its dysregulation during tumorigenesis. This understanding has underscored the urge...