Nutrient transporter-oriented nanoinhibitor counteracts intracellular metabolic reprogramming for RT-resistant HCC treatment [0.03%]
以营养转运体为导向的纳米抑制剂通过抗衡细胞内代谢重编程来对抗RT耐药性的HCC治疗
Yuehua Wang,Zhenjie Wang,Mengnan Liu et al.
Yuehua Wang et al.
Radiotherapy (RT) is the primary treatment modality for hepatocellular carcinoma (HCC). Inevitably, the X-ray exposure also increases the metabolic stress and energy demands in surviving tumor cells, which leads to metabolic reprogramming t...
Enhanced efficacy of immune checkpoint inhibitors by folate-targeted multifunctional drug through synergistic therapy inducing ferroptosis and immunogenic cell death in bladder cancer [0.03%]
叶酸靶向多功能药物通过诱导膀胱癌铁死亡和免疫原性细胞死亡的协同疗法增强免疫检查点抑制剂的疗效
Yibo Shi,Guangrui Fan,Enguang Yang et al.
Yibo Shi et al.
Purpose: The research aims to elucidate the anti-tumor mechanism of the composite multifunctional folate-targeted drug DIFP-FA through sonodynamic therapy (SDT), chemodynamic therapy (CDT), and chemotherapy, as well as it...
Multienzyme active melanin nanodots for antioxidant-immunomodulatory therapy of hyperoxia lung injury [0.03%]
用于高氧性肺损伤抗氧化-免疫调节治疗的多酶活性黑色素纳米点
Jinghua Sun,Juan Wu,Wenjing Zhao et al.
Jinghua Sun et al.
Supraphysiological oxygen is the most conventional method of treating patients with acute respiratory failure, but prolonged exposure to hyperoxia generates large amounts of reactive oxygen species (ROS) in the lungs, leading to hyperoxia l...
Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing [0.03%]
作为伤口愈合中外泌体类似物的细胞膜衍生纳米囊泡
Wenwen Li,Huihui Zhang,Lianglong Chen et al.
Wenwen Li et al.
Cell membrane-derived nanovesicles (NVs) have emerged as promising alternatives to extracellular vesicles (EVs) for wound healing applications, addressing the limitations of traditional EVs, which include insufficient targeting capability, ...
Oxygen tension regulating nanoformulation for the improved photodynamic therapy of hypoxic tumors [0.03%]
用于改善缺氧肿瘤光动力治疗的氧张力调节纳米制剂
Yihenew Simegniew Birhan,Chia-Yen Hsu,Hsiu-Ping Yu et al.
Yihenew Simegniew Birhan et al.
The clinical efficacy of photodynamic therapy (PDT) is hampered by the low oxygen tension highly prevalent in solid tumors. Hence, improving the oxygen tension by suppling hyperbaric oxygen (HBO), through oxygen delivery nanoarchitectures o...
Targeting capture and eradicate circulating tumor cells by activated platelet derived vehicle for inhibiting triple-negative breast cancer metastasis [0.03%]
通过激活的血小板衍生载体捕获并根除循环肿瘤细胞以抑制三阴性乳腺癌转移
Hongmei Zhang,Jinlan Jiao,Yongxuan Long et al.
Hongmei Zhang et al.
Circulating tumor cells (CTCs) are cardinal intermediaries in the metastatic cascade, particularly in triple-negative breast cancer (TNBC), owing to their high-affinity interactions that bolster survival and dissemination. Addressing this p...
A bioactive three-layered skin substitute based on ECM components effectively promotes skin wound healing and regeneration [0.03%]
基于ECM组分的活性三层皮肤替代品可有效促进伤口愈合和皮肤再生
Carlos Chocarro-Wrona,Paula Pleguezuelos-Beltrán,Julia López de Andrés et al.
Carlos Chocarro-Wrona et al.
To overcome the limitations of conventional skin tissue engineering (TE), 3D biofabrication approaches are being developed. However, tissue mimicry should be further improved in skin models. Here, we developed and characterized biomimetic h...
A brief strategy for the preparation of silk fibroin-copper sulfide-based electrospun nanofibrous membranes with photothermal antimicrobial properties to accelerate the infected wound healing [0.03%]
用于加速感染伤口愈合的具有光热抗菌性能的基于静电纺丝纳米纤维素膜的简明制备策略
Rui Cai,Jiayu Zhao,Peirong Zhou et al.
Rui Cai et al.
Bacterial infections often hinder the wound-healing process. Antibiotics are commonly used to eradicate bacteria, but long-term use can lead to the development of drug-resistant bacteria. Photothermal therapy (PTT) is a promising technology...
Huixue Wu,Yiran Qin,Kexin Li et al.
Huixue Wu et al.
Effective control of plaque accumulation is an important strategy for reducing the risk of both localized oral health issues and systemic diseases associated with plaque. However, existing approaches for preventing plaque accumulation exhib...
Tissue-specific extracellular matrix for the larger-scaled expansion of spinal cord organoids [0.03%]
用于脊髓类器官大规模扩增的组织特异性细胞外基质
Yanjun Guan,Zhibo Jia,Xing Xiong et al.
Yanjun Guan et al.
Spinal cord organoids (SCOs) are in vitro models that faithfully recapitulate the basic tissue architecture and cell types of the spinal cord and play a crucial role in developmental studies, disease modeling, and drug screening. Physiologi...