Dynamic Col-HZ Hydrogel with efficient delivery of bioactivator promotes ECM deposition and cartilage formation [0.03%]
具有高效生物活化剂传递性能的动态Col-HZ水凝胶可促进ECM沉积和软骨形成
Honglei Wang,Xu Wu,Lili Chen et al.
Honglei Wang et al.
Efforts in cartilage tissue engineering to repair injuries have seen limited success, primarily due to the inability of scaffold materials to establish a microenvironment conducive to extracellular matrix (ECM) deposition by chondrocytes. H...
Dual-network hydrogel loaded with antler stem cells conditioned medium and EGCG promotes diabetic wound healing through antibacterial, antioxidant, anti-inflammatory, and angiogenesis [0.03%]
负载鹿茸干细胞条件培养基和EGCG的双网络水凝胶通过抗菌、抗氧化、抗炎及促血管生成功能促进糖尿病伤口愈合
Xianyi He,Yichen Gao,Xia Wang et al.
Xianyi He et al.
Diabetic wound healing is characterized by persistent inflammation, reactive oxygen species overproduction, bacterial infection, and compromised angiogenesis. In recent years, Antler Stem Cells (ASCs) have attracted attention because of the...
Recent advances in bioactive hydrogel microspheres: Material engineering strategies and biomedical prospects [0.03%]
生物活性水凝胶微球的最新进展：材料工程策略及其在生物医学中的前景
Junjiang Yue,Zhengbiao Liu,Lu Wang et al.
Junjiang Yue et al.
Hydrogel microspheres are a class of hydrophilic polymeric particles in microscale, which has been developed as a new type of functional biomaterials for wide-range biomedical applications in recent years. This review provides a comprehensi...
Three-dimensional matrix stiffness-based stem cell soil: Tri-phase biomechanical structure promoted human dental pulp stem cells to achieve pulpodentin regeneration [0.03%]
基于三维矩阵刚度的干细胞土壤：三相生物力学结构促进人牙髓干细胞实现牙髓 dentin 再生
Xiujuan Li,Yijing Xia,Zhiying Wang et al.
Xiujuan Li et al.
The regeneration of the pulp-dentine complex is characterized by organizational diversity, with both dentine and pulp being essential for regenerating a complete tooth-like structure. Matrix stiffness plays a crucial role in guiding the mul...
Integrating melt electrowriting (MEW) PCL scaffolds with fibroblast-laden hydrogel toward vascularized skin tissue engineering [0.03%]
熔融电写(PCL)支架与成纤维细胞水凝胶的集成朝着血管化皮肤组织工程发展
Xixi Wu,Fenghua Zhao,Hui Wang et al.
Xixi Wu et al.
Three-dimensional (3D) skin equivalents (SEs) are promising platforms for studying skin disease or assessing the safety of skin-relevant products. Vascularization, which improves the functionality of reconstructed skin, is one of the remain...
Self-assembled genistein nanoparticles suppress the epithelial-mesenchymal transition in glioblastoma by targeting MMP9 [0.03%]
自组装的大豆异黄酮纳米粒通过靶向MMP9抑制胶质母细胞瘤的上皮间充质转化
Qingyu Zhao,Yong Li,Qian Sun et al.
Qingyu Zhao et al.
Glioblastoma (GBM) is the most prevalent and aggressive primary malignant brain tumor in adults, known for its poor prognosis and resistance to conventional treatments. The blood-brain barrier (BBB) presents a significant challenge in deliv...
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage [0.03%]
补骨脂酸刻蚀的ZIF-8纳米颗粒通过抑制炎症信号通路和修复线粒体损伤来延缓骨关节炎的发展
Yu Zhang,Qiqi Lou,Hao Lian et al.
Yu Zhang et al.
Osteoarthritis (OA) is the most common chronic inflammatory joint disease. Improving the joint inflammatory microenvironment is expected to promote early intervention and delay the progression of OA. However, effective strategies for inhibi...
Injectable sustainable andrographolide-releasing hydrogel for long-lasting alleviation of osteoarthritis and regulation of chondrocyte autophagy via PRKCA/EGFR [0.03%]
可注射的可持续穿心莲内酯释放水凝胶通过PRKCA/EGFR长期缓解骨关节炎并调节软骨细胞自噬
Yang Chen,Peipei He,Siyi Tao et al.
Yang Chen et al.
Osteoarthritis is one of the most prevalent age-related joint diseases, with chondrocyte inflammation and autophagy dysregulation serving as pivotal pathogenesis factors. Andrographolide (AD), a phytochemical identified in Andrographis pani...
Ultrasound-responsive engineered bacteria mediated specific controlled expression of catalase and efficient radiotherapy [0.03%]
超声响应的工程菌介导的过氧化氢酶特异可控表达及高效的放疗
Zichao Liu,Lingling Lei,Zenan Zhang et al.
Zichao Liu et al.
The limited efficacy of radiotherapy (RT) in breast cancer is intricately linked to the hypoxic tumor microenvironment. Delivering catalase (CAT) to decompose hydrogen peroxide (H2O2) into oxygen is a promising strategy to address this. How...
Marta Gonçalves,Sofia Brito,Chaeyeon Song et al.
Marta Gonçalves et al.
Thin film deposition is essential in the cosmetic industry, where formulations such as foundations and concealers rely on uniform layer formation to conceal pores and texture irregularities for a natural and even appearance. However, variat...