For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy [0.03%]
肿瘤微环境的争论：基于纳米颗粒的主动癌症治疗策略
Soroush Karimi,Roksana Bakhshali,Soheil Bolandi et al.
Soroush Karimi et al.
Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive and innovative perspective on how nanomedicine can modify the TME to enhance thera...
Versatile application of magnesium-related bone implants in the treatment of bone defects [0.03%]
镁相关骨植入物在骨缺损治疗中的广泛应用
Mijia Tao,Yutao Cui,Shicai Sun et al.
Mijia Tao et al.
Magnesium-related bone implants have garnered significant attention in the treatment of bone defects. The applications of magnesium in promoting bone repair mainly include degradable magnesium-based scaffolds owing to its special physical p...
Magnesium oxide nanoparticles modulate phase separation to form trabecular-structured cryogels for bone defect repair [0.03%]
氧化镁纳米颗粒调节相分离以形成类骨小梁结构的冷冻水凝胶用于骨缺损修复
Botao Liu,Mingming Hao,Jianping Chen et al.
Botao Liu et al.
Critical-sized bone defects pose notable therapeutic challenges and often require extensive bone grafts for effective intervention, leading to a substantial medical burden. The scarcity of autologous bone and the complex architecture of tra...
Chondroitin sulfate nanoparticles based on co-delivery dual drug induced ferroptosis in lung cancer cells by disrupting mitochondrial oxidative homeostasis [0.03%]
干扰 mitochondria 氧化稳态的双药共传递硫酸软骨素纳米粒诱导肺癌细胞发生铁死亡
He Wang,Shuimu Lin,Jiacui Xie et al.
He Wang et al.
Mitochondrial REDOX homeostasis is unbalanced by large amounts of reactive oxygen species production and reduced glutathione, leading to lipid oxidation-induced ferroptosis, which enhanced cancer immunotherapy. Thus, disrupting mitochondria...
Gravitational forces and matrix stiffness modulate the invasiveness of breast cancer cells in bioprinted spheroids [0.03%]
重力和基质刚度调节生物打印的乳腺癌细胞团中癌细胞的侵袭性
Louise Breideband,Kaja Nicole Wächtershäuser,Ryan Sarkar et al.
Louise Breideband et al.
The progression of breast cancer is influenced by the stiffness of the extracellular matrix (ECM), which becomes stiffer as cancer advances due to increased collagen IV and laminin secretion by cancer-associated fibroblasts. Intriguingly, b...
Soo-Hwan Lee,Sungjae Yoo,Sung Hoon Kim et al.
Soo-Hwan Lee et al.
Medical and implantable devices are essential instruments in contemporary healthcare, improving patient quality of life and meeting diverse clinical requirements. However, ongoing problems such as bacterial colonization, biofilm development...
Self-assembled antioxidant enzyme-mimicking hydrogel: Targeting oxidative stress and macrophage organization for improving degenerated intervertebral discs [0.03%]
自组装抗氧化酶模拟水凝胶：针对氧化应激和巨噬细胞组织以改善退变间盘
Yudong Fu,Hua Sun,Yongchao Jin et al.
Yudong Fu et al.
Intervertebral disc degeneration (IVDD) is a major contributor to lower back pain. At present, antioxidant therapy is regarded as one of the most promising strategies for treating IVDD, due to the critical role of reactive oxygen species (R...
An injectable gambogic acid loaded nanocomposite hydrogel enhances antitumor effect by reshaping immunosuppressive tumor microenvironment [0.03%]
负载 gambogic 酸的可注射纳米复合水凝胶通过重塑免疫抑制性肿瘤微环境增强抗肿瘤效果
Dan Lei,Wanru Wang,Jianhang Zhao et al.
Dan Lei et al.
Gambogic acid(GA)is a natural compound that exhibits strong antitumor activity against a variety of tumors. However, its poor water solubility, low specificity, and high toxicity lead to inevitable systemic adverse effects. To minimize side...
Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistant Klebsiella pneumoniae [0.03%]
对抗碳青霉烯类耐药肺炎克雷伯菌引起的肺炎的吸入pH响应载多粘菌素B白蛋白纳米粒
Ziling Li,Huiling Lei,Jiannan Hu et al.
Ziling Li et al.
The pneumonia induced by carbapenem resistant Klebsiella pneumoniae (CRKP) has high morbidity and mortality. Among the antibiotics currently available, polymyxin B (PMB) is considered to be the last line of defense. Routine intravenous admi...
Inflammatory microenvironment-responsive nanomicelles for acute lung injury therapy: ROS-scavenging and macrophage repolarization [0.03%]
炎症微环境响应型纳米胶束用于急性肺损伤治疗：ROS清除和巨噬细胞重编程
Chang Liu,Rui Zhou,Baiqiao Chen et al.
Chang Liu et al.
The pathogenesis of acute lung injury (ALI) is characterized by an uncontrolled inflammatory response, marked by excessive production of reactive oxygen species (ROS) and the infiltration of inflammatory cells, particularly macrophages, whi...