Crosslinking stabilization strategy: A novel approach to cartilage-like repair of annulus fibrosus (AF) defects [0.03%]
交联稳定策略：一种用于修复纤维环(AF)缺陷的类似软骨的新方法
Zihan Wang,Lei Wang,Shaoshuo Li et al.
Zihan Wang et al.
Lumbar disc degeneration due to annulus fibrosus (AF) defects poses a significant challenge in clinical treatment Current treatments exhibit limited repair efficacy and a high recurrence rate. To address this, we devised a novel approach of...
Treatment of lung diseases via nanoparticles and nanorobots: Are these viable alternatives to overcome current treatments? [0.03%]
通过纳米粒子和纳米机器人治疗肺部疾病：这些是克服现有治疗方法的可行选择吗？
Meekha George,Rabah Boukherroub,Amitav Sanyal et al.
Meekha George et al.
Challenges: Respiratory diseases remain challenging to treat, with current efforts primarily focused on managing symptoms rather than maintaining overall lung health. Traditional treatment methods, such as oral or parente...
GlycoRNA-rich, neutrophil membrane-coated, siMT1-loaded nanoparticles mitigate abdominal aortic aneurysm progression by inhibiting the formation of neutrophil extracellular traps [0.03%]
富含糖基化RNA，中性粒细胞膜包被，装载siMT1的纳米颗粒通过抑制中性粒细胞外陷阱的形成减轻腹主动脉瘤的进展
Zhiwei Zhang,Tianyu Ling,Qingwei Ding et al.
Zhiwei Zhang et al.
Abdominal aortic aneurysm (AAA) is a life-threatening vascular condition. Currently, there are no clinically available pharmacological interventions that can stop the progression of AAA, primarily due to the incomplete understanding of its ...
Poly(glycerol succinate) hydrogel promotes spinal cord repair by regulating bio-energetic activity in severe injury [0.03%]
聚琥珀酰甘油水凝胶通过调节严重脊髓损伤中的生物能量活动来促进脊髓修复
Ang Li,Xin Miao,Zhengzhe Han et al.
Ang Li et al.
Traumatic spinal cord injury (SCI) is a major clinical challenge, imposing a significant burden on both patients and healthcare systems. The complexity of SCI stems from its multifactorial pathogenesis, incorporating a variety of regulating...
Construction of dual-targeted liposomes loaded with celastrol and their application in treating intrahepatic cholangiocarcinoma [0.03%]
负载雷公藤红素的双靶向脂质体的构建及其在治疗肝内胆管细胞癌中的应用研究
Jun Tang,Yimeng Yang,Zihan He et al.
Jun Tang et al.
Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor with limited treatment options. Celastrol (Cela) shows potential treatment for ICC, but its clinical use is hindered by poor water solubility and toxic side effects. To address...
PD-L1 siRNA incorporation into a cationic liposomal tumor mRNA vaccine enhances cytotoxic T cell activation and prevents immune evasion [0.03%]
PD-L1 siRNA在阳离子脂质体肿瘤mRNA疫苗中的包封增强了细胞毒性T细胞的激活并防止了免疫逃逸
Jingsheng Zhou,Yuanyuan Li,Xianghe Jiang et al.
Jingsheng Zhou et al.
Engaging antigen-presenting cells and T lymphocytes is essential for invigorating the immune system's response to cancer. Nonetheless, challenges such as the low immunogenicity of tumor antigens, the genetic heterogeneity of tumor cells, an...
Interlacing biology and engineering: An introduction to textiles and their application in tissue engineering [0.03%]
交织生物学和工程学：纺织品及其在组织工程中应用的简介
S Scholpp,L A Hoffmann,E Schätzlein et al.
S Scholpp et al.
Tissue engineering (TE) aims to provide personalized solutions for tissue loss caused by trauma, tumors, or congenital defects. While traditional methods like autologous and homologous tissue transplants face challenges such as donor shorta...
Peptide-modified mesoporous silica nanoparticles for the coordinated regulation of macrophage polarization and pyroptosis in the treatment of implant-related infections [0.03%]
用于调节植入相关感染中巨噬细胞极化和焦亡的肽修饰介孔二氧化硅纳米颗粒
Zhi Li,Yuhang Wang,Xingshi Yuan et al.
Zhi Li et al.
Implant-related infections (IRIs) present a significant challenge in clinical treatment because of the formation of biofilms. The complex architecture of biofilms not only impedes antibiotic penetration, fostering the evolution of multidrug...
Purified bone xenografts: A novel and efficient animal bone substitute derived from an optimized supercritical CO2 treatment [0.03%]
纯化后的骨源异种移植物：一种经优化超临界二氧化碳处理后得到的新型高效动物骨替代物
Solène Rota,Ludovic Sicard,Justine Perarnaud et al.
Solène Rota et al.
Bone xenografts represent a promising alternative to autologous or allograft transplants, yet antigenicity in animal-derived tissues remains a major limitation to their clinical use. To provide any risk of contamination or allogenic rejecti...
Tailored virus-mimicking nanoparticles mediate high transfection of pTRAIL for bystander effects in oncotherapy [0.03%]
量身定制的病毒模拟纳米颗粒介导pTRAIL的高转染以在肿瘤治疗中产生旁观者效应
Ruirong Wu,Xiufeng Wu,Lan Zhang et al.
Ruirong Wu et al.
Viral vectors share unparalleled gene-transfection efficiency due to protein capsid-mediated target-cell recognition and efficient cellular translocation, but clinical applications are seriously hampered by potential biosafety issues. Herei...