Bioinspired nanomedicines for the management of osteosarcoma: Recent progress and perspectives [0.03%]
用于骨肉瘤管理的仿生纳米药物：最新进展和展望
Kai Cui,Fei Ren,Jian Yu et al.
Kai Cui et al.
Osteosarcoma (OS) is the most prevalent malignant primary bone tumor, predominantly affecting children and young adults between the ages of 11 and 20. OS presents huge challenges in treatment because of its aggressive nature and high metast...
Cryo-trojan mesenchymal stem cells as non-living tumor-homing supercarriers for enhanced drug delivery and immune activation in prostate cancer [0.03%]
前列腺癌中冷冻trojan间充质干细胞作为非生物性肿瘤定位超级载体，用于增强药物传递和免疫激活
Chengran Wang,Xinao Rong,Fuqiang Zhang et al.
Chengran Wang et al.
Background: Prostate cancer remains a leading cause of cancer-related mortality, with conventional therapies limited by systemic toxicity and poor tumor targeting. Developing innovative drug delivery systems that enhance ...
Gold nanoparticles modulate macrophage polarization to promote skeletal muscle regeneration [0.03%]
金纳米颗粒通过调节巨噬细胞极化来促进骨骼肌再生
Lining Xu,Jiahuang Qiu,Quanzhong Ren et al.
Lining Xu et al.
Skeletal muscle regeneration is a complex process that depends on the interplay between immune responses and muscle stem cell (MuSC) activity. Macrophages play a crucial role in this process, exhibiting distinct polarization states-M1 (pro-...
Uniform and controllable surface nano-structure on polyetheretherketone implants can regulate mechanical property to enhance soft tissue integration through Piezo1/TGF-β1 signaling axis [0.03%]
聚醚醚酮植入物上均匀且可控制的表面纳米结构可以通过Piezo1/TGF-β1信号轴调节机械性能，以增强软组织整合
Sida Liu,Yixuan Chen,Gandong Zhou et al.
Sida Liu et al.
Polyetheretherketone (PEEK) has potential to repair the orbital floor bone defects following craniofacial trauma and orbital surgery. However, the inertness of the material impedes the soft tissue integration of implants, leading to complic...
An anti-inflammatory and anti-fibrotic Janus hydrogel for preventing postoperative peritoneal adhesion [0.03%]
具有抗炎和抗纤维化作用的詹纳斯水凝胶在预防术后腹膜粘连方面的应用
Zhengjun Li,Lili Yang,Qi Jin et al.
Zhengjun Li et al.
Postoperative peritoneal adhesion (PPA) is pathological tissue hyperplasia between surgical wounds and nearby organs. Currently, traditional double-sided bioadhesives are limited in preventing PPA due to the indiscriminate adhesive properti...
A hybrid implant combining a macroporous device with immunoprotective microcapsules for cell therapy applications: A conceptual in vitro study [0.03%]
结合宏观设备和免疫保护微胶囊的细胞疗法应用混合植入物的概念性体外研究
Adam Stell,Vijayaganapathy Vaithilingam,Sami G Mohammed et al.
Adam Stell et al.
Cell encapsulation strategies including macro- and micro-delivery devices have been widely used in cell therapy due to their ability to provide immunoprotection to the transplanted cells. While both strategies can provide mechanical and phy...
Cephalopod proteins for bioinspired and sustainable biomaterials design [0.03%]
用于生物启发和可持续生物材料设计的头足类蛋白质
Iana Lychko,Inês Padrão,Afonso Vicente Eva et al.
Iana Lychko et al.
Nature offers a boundless source of inspiration for designing bio-inspired technologies and advanced materials. Cephalopods, including octopuses, squids, and cuttlefish, exhibit remarkable biological adaptations, such as dynamic camouflage ...
Preparation of hydrogel microsphere and its application in articular cartilage injury [0.03%]
水凝胶微球的制备及其在关节软骨损伤中的应用研究
Zehua Wang,Xiaoxia Li,Yaping Jiang et al.
Zehua Wang et al.
In recent years, hydrogel microspheres have garnered significant attention due to their unique structure and functionality, demonstrating substantial potential in articular cartilage injury repair. This paper provides a comprehensive overvi...
Multi-functionalized probiotics through layer-by-layer coating with tannic acid-Mg2+ and casein phosphopeptide complexes for preventing ulcerative colitis [0.03%]
通过单宁酸-Mg2+和酪蛋白磷肽复合物的层层自组装改性益生菌以预防溃疡性结肠炎
Zhanyin Qian,Zihan Zhai,Mingjin Ren et al.
Zhanyin Qian et al.
Gut microbiota imbalance-induced inflammatory response and oxidative stress are two of the main reasons causing ulcerative colitis (UC). Probiotics show potent modulating effects on microbiota imbalance and have been considered as an optima...
Microenvironment-responsive nanoparticles functionalized titanium implants mediate redox balance and immunomodulation for enhanced osseointegration [0.03%]
微环境响应型纳米粒子修饰的钛植入物用于调节氧化还原平衡和免疫调控从而提高骨整合能力
Wei Chen,Yifei Pan,Catherine Huihan Chu et al.
Wei Chen et al.
Various pathological conditions (e.g., diabetes, osteoporosis) are accompanied by persistent oxidative stress, which compromises the immune microenvironment and poses substantial challenges for osseointegration. Reactive oxygen species (ROS...