In situ 3D bioprinted GDMA/Prussian blue nanozyme hydrogel with wet adhesion promotes macrophage phenotype modulation and intestinal defect repair [0.03%]
具有湿粘附性的原位3D生物打印的GDMA/普鲁士蓝纳米酶水凝胶促进巨噬细胞表型调节和肠道缺损修复
Yang Su,Jingyi Ju,Chentao Shen et al.
Yang Su et al.
Developing hydrogels with wet-adhesion, immunomodulation and regenerative repair capabilities in intestinal repair remains a formidable challenge. In the present study, the development of an anti-inflammatory, wet-adhesive, decellularized e...
Exosome isolation and characterization for advanced diagnostic and therapeutic applications [0.03%]
用于先进诊断和治疗应用的外泌体分离与特性分析
Nobendu Mukerjee,Arghya Bhattacharya,Swastika Maitra et al.
Nobendu Mukerjee et al.
Advancements in exosome isolation technologies are pivotal for transforming personalized medicine and enhancing clinical diagnostics. Exosomes, small extracellular vesicles with diameters ranging between 30 and 150 nm, are secreted into bod...
Cyborg microbe biohybrids with metal-organic coating layers: Strategies, functionalisation and potential applications [0.03%]
具有金属有机涂层的赛博微生物杂合体：策略、功能化和潜在应用
Zichen Wu,Ke Xu,Regina Huang et al.
Zichen Wu et al.
The integration of living microbes, specifically bacteria and fungi, with metal-organic nanocoatings has led to the recent development of cyborg microbe biohybrids, which show excellent adaptability and functionality for a wide range of pot...
Engineered extracellular vesicles as imaging biomarkers and therapeutic applications for urological diseases [0.03%]
用于泌尿系统疾病的工程化细胞外囊泡作为影像学生物标志物和治疗应用
Liao-Yuan Li,Si-Yuan Liang,Mao-Ping Cai et al.
Liao-Yuan Li et al.
With the ever-increasing burden of urological diseases, the need for developing novel imaging biomarkers and therapeutics to manage these disorders has never been greater. Extracellular vesicles (EVs) are natural membranous nanoparticles an...
Engineering exosome membrane disguised thermal responsive system for targeted drug delivery and controlled release across the blood-brain barrier [0.03%]
工程化外泌体膜伪装的热响应系统用于药物靶向递送及跨越血脑屏障的控制释放
Zhe Han,Haina Huang,Boyan Li et al.
Zhe Han et al.
The blood-brain barrier (BBB) presents a significant challenge for the delivery of chemotherapy drugs to brain tumors, leading to ineffective drug concentrations at the tumor site and contributing to chemotherapy resistance. The hypoxic tum...
Enhancing clinical precision in lung cancer tissue biopsy through elevated response-threshold of an endoplasmic reticulum-targeted fluorogenic probe [0.03%]
通过提高靶向内质网的荧光探针的响应阈值来提升肺部组织活检的临床精度
Zhiyang Yuwen,Xinglong Chen,Kexin Chen et al.
Zhiyang Yuwen et al.
Lung carcinoma is the leading cause of mortality globally, posing a significant public health concern. Fluorescent-mediated tumor imaging is emerging as a novel diagnostic and therapeutic approach in clinical practice. Nevertheless, traditi...
Enhanced anticancer effect of carfilzomib by codelivery of calcium peroxide nanoparticles targeting endoplasmic reticulum stress [0.03%]
钙过氧化物纳米颗粒共传递提高卡非佐米的抗癌作用靶向内质网应激
Dan Yin,Xuan Wu,Xu Chen et al.
Dan Yin et al.
Encouraged by the clinical success of proteasome inhibitors treating hematological malignancy, continuous efforts are being made to improve their efficacy and expand their applications to solid tumor therapy. In this study, liposomes were u...
Endoscopic nasal delivery of engineered endothelial progenitor cell-derived exosomes improves angiogenesis and neurological deficits in rats with intracerebral hemorrhage [0.03%]
工程化内皮祖细胞衍生的外泌体的内窥镜鼻腔输送可改善脑出血大鼠的血管生成和神经功能缺损
Gui Wan,Zhenwei Li,Lingui Gu et al.
Gui Wan et al.
Intracerebral hemorrhage (ICH) remains a life-threatening condition due to its high mortality and limited treatment options. This study explores a novel therapeutic strategy using engineered exosomes derived from endothelial progenitor cell...
Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects [0.03%]
共轴印刷负载神经干细胞的微纤维与脐带间充质干细胞衍生外泌体联合疗法在完全交感性脊髓缺损中的应用
Xinda Li,Jin Zhang,Yi Zhang et al.
Xinda Li et al.
Motor function recovery after complete spinal cord injury remained as a challenge in medical field, while one of the key approaches is promoting the local microenvironments. In this research, we performed a conjugated therapy by transplanta...
Amphiphilic Janus nanoparticles for a superhydrophobic coating on the enamel surface to prevent caries [0.03%]
用于牙釉质表层超疏水涂层的两亲性阴阳纳米粒子以防止龋齿
Chenhui Chen,Yuqi Xie,Qinfeiyang Zhang et al.
Chenhui Chen et al.
Bacteria are pivotal in the etiology of dental caries, underscoring the critical importance of effective plaque control in mitigating dental tissue diseases. Superhydrophobic materials, with their exceptional properties of non-wettability, ...