Oxymatrine and astragaloside IV co-loaded liposomes: Scale-up purposes and their enhancement of anti-PD-1 efficacy against breast cancer [0.03%]
氧化苦参碱与羟基黄茋共载脂质体：放大制备及其增强抗PD-1治疗乳腺癌的增效作用
Liangyin Wei,Hong Wang,Xietao Ye et al.
Liangyin Wei et al.
The response rate of programmed cell death protein-1 (PD-1) inhibitors in breast cancer remains unsatisfactory, primarily due to the limited infiltration and activity of tumor-infiltrating T lymphocytes (TILs). Previous studies demonstrated...
PTEN/PI3K/AKT pathway activation with hypoxia-induced human umbilical vein endothelial cell exosome for angiogenesis-based diabetic skin reconstruction [0.03%]
低氧诱导的人脐静脉内皮细胞外泌体活化PTEN/PI3K/AKT信号通路促进糖尿病皮肤组织工程血管生成
Zhenming Li,Yuhao Bai,Hao Wu et al.
Zhenming Li et al.
Diabetic skin, a major clinical challenge due to impaired wound healing, is often exacerbated by a hypoxic microenvironment at the wound site. Exosomes have been proven to have excellent biological activities and applied to solve many bioen...
Co-encapsulated Ce6 + CpG and biopeptide-modified liposomes for enhanced transdermal photo-immunotherapy of superficial tumors [0.03%]
用于增强浅表肿瘤透皮光免疫治疗的共封装Ce6+CpG和生物肽修饰脂质体
Shaozhen Wang,Chen Yang,Yuanyuan Zhang et al.
Shaozhen Wang et al.
Cancer immunotherapy encounters challenges of a low treatment response rate due to the tumor immunosuppressive microenvironment and immune-related adverse events caused by off-target immunotherapy agents delivered through systemic administr...
Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer [0.03%]
用于乳腺癌联合光热和化疗增强的靶向治疗的二维石墨烯纳米材料
Xiongjie Zhu,Juanjuan Lei,Chao Jiang et al.
Xiongjie Zhu et al.
Breast cancer is one of the most common malignant tumors in women, accounting for 7-10 % of all malignant tumors in the body. Second only to uterine cancer, it poses a significant threat to women's health. In this study, a two-dimensional m...
W-GA nanodots with multienzyme activities alleviate the inflammatory microenvironment in the treatment of acute wounds [0.03%]
具有多种酶活性的W-GA纳米点可缓解急性伤口治疗中的炎性微环境
Yang Zheng,Qingrong Li,Xu Jin et al.
Yang Zheng et al.
Acute wounds present a significant clinical challenge due to delayed healing, which is often exacerbated by elevated levels of reactive oxygen species (ROS). These high ROS concentrations hinder the natural healing process, leading to prolo...
Bioinspired hydrogel for sustained minocycline release: A superior periodontitis solution [0.03%]
仿生水凝胶用于持续缓释美满霉素：一种卓越的牙周病解决方案
Shiyao Liu,Wenqian Zheng,Lina Wang et al.
Shiyao Liu et al.
Periodontitis treatment remains challenging due to the limitations of clinical medication therapies, including drug cytotoxicity, poor drug retention, immune imbalances, and epithelial barrier damage. Here, inspired by bioisosterism, we dev...
Self-healing injectable multifunctional hydrogels for intervertebral disc disease [0.03%]
用于治疗椎间盘疾病的自愈可注射多功能水凝胶
Zhengrong Gu,Yi He,Honglin Xiang et al.
Zhengrong Gu et al.
Intervertebral disc degeneration (IVDD) is increasingly prevalent in aging societies and poses a significant health challenge. Due to the limited blood supply to the disc, oral medications and systemic treatments are often ineffective. Cons...
Functional aligned mesenchymal stem cell sheets fabricated using micropatterned thermo-responsive cell culture surfaces [0.03%]
使用微图案热响应细胞培养表面制造的功能性成束的间充质干细胞片
Kenichi Nagase,Hasumi Kuramochi,David W Grainger et al.
Kenichi Nagase et al.
Mesenchymal stem cells (MSCs) are frequently applied for cell transplantation and regenerative therapy because they secrete diverse therapeutic cytokines that prompt immuno-stimulatory and tissue repair processes. Furthermore, cultured MSC ...
Ultrasound-actuated ion homeostasis perturbator for oxidative damage-augmented Ca2+ interference therapy and combined immunotherapy [0.03%]
超声波驱动的离子稳态干扰器用于氧化损伤增强的钙干扰疗法和联合免疫治疗
Mi Yang,Yaqin Hu,Xiuxiu Hao et al.
Mi Yang et al.
Calcium ion therapy has shown promise for cancer treatment, but its efficacy is limited by the cellular calcium buffering mechanism. Herein, an ion homeostasis disruptor (PCCa) was synthesized using an in situ mineralization method. The sur...
3D-printed intelligent photothermal conversion Nb2C MXene composite scaffolds facilitate the regulation of angiogenesis-osteogenesis coupling for vascularized bone regeneration [0.03%]
3D打印的智能光热转换Nb2C MXene复合支架有利于调控血管生成-成骨耦合以促进血管化骨再生
Yi Zhang,Mucong Li,Hao Zhang et al.
Yi Zhang et al.
Personalized porous scaffold materials for bone defect repair, with adjustable mechanical strength and porosity via 3D printing technology, have made significant strides in the bone tissue engineering. However, their ability to regulate the...