Dual-targeted microbubbles for atherosclerosis therapy: Inducing M1 macrophage apoptosis by inhibiting telomerase activity [0.03%]
双重靶向微气泡疗法：通过抑制端粒酶活性诱导M1型巨噬细胞凋亡以治疗动脉粥样硬化
Wei Zeng,Zhengan Huang,Yalan Huang et al.
Wei Zeng et al.
The progression of atherosclerosis (AS) is closely associated with M1 macrophages. Although the activation of macrophage telomerase during plaque formation has been documented, targeted modulation strategies remain challenging. In this stud...
Defect-engineered magnetic bismuth nanomedicine for dual-modal imaging and synergistic lung tumor therapy [0.03%]
用于双模态成像和协同治疗肺癌的缺陷工程磁性铋纳米药物
Pengpeng Jia,Jie Tu,Hongyu Shen et al.
Pengpeng Jia et al.
Bismuth sulfide (Bi2S3) nanomaterials are recognized for their potential in tumor therapy due to their narrow bandgap and low toxicity. However, limited photothermal conversion efficiency (PCE) and low carrier density restrict their broader...
Micro-fragmented collagen hydrogel wound dressing: Enhanced porosity facilitates elevated stem cell survival and paracrine effects for accelerated wound maturation [0.03%]
微碎片化胶原蛋白水凝胶伤口敷料：增强的多孔性促进干细胞存活和旁分泌效应从而加速伤口成熟
Changgi Hong,Youngseop Lee,Haeun Chung et al.
Changgi Hong et al.
Human Adipose-derived stem cells (hADSCs), known for their mesenchymal stem cell properties, including multilineage differentiation and self-renewal, hold significant promise for chronic wound regeneration. Typically, hADSCs are utilized in...
pH-driven butterfly effect for cascade-amplified tumor therapy based on thalidomide coordinated Fe-HMME nanoplatform [0.03%]
基于硫灵配位Fe-HMME纳米平台的pH驱动级联放大肿瘤治疗体系
Botao Qu,Qian Wang,Yuxin Zhou et al.
Botao Qu et al.
A promising approach for treating intractable cancers has been presented by photodynamic therapy (PDT). However, the limited penetration depth of PDT and suboptimal monotherapy efficacy of PDT significantly restrict its clinical application...
Mechanically robust non-swelling cold water fish gelatin hydrogels for 3D bioprinting [0.03%]
一种用于3D生物打印的机械稳定且不膨胀的冷水鱼胶原水凝胶
Tobias Hammer,Ke Yang,Tobias Spirig et al.
Tobias Hammer et al.
Three-dimensional (3D) bioprinting of hydrogels allows embedded cells to be patterned and hosted in an extracellular matrix (ECM)-mimicking environment. This method shows great promise for the engineering of complex tissues on account of th...
Novel pH-responsive lipid nanoparticles deliver UA-mediated mitophagy and ferroptosis for osteoarthritis treatment [0.03%]
一种新型pH响应型脂质纳米颗粒介导柚皮素调控自噬及铁死亡治疗骨关节炎的研究
Guoliang Yi,Min Li,Jiayi Zhou et al.
Guoliang Yi et al.
Synovial inflammation plays a crucial role in osteoarthritis (OA) development, leading to chronic inflammation and cartilage destruction. Although targeting synovitis can alleviate OA, clinical outcomes have been disappointing due to poor d...
Harnessing engineered exosomes as METTL3 carriers: Enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment [0.03%]
利用工程外泌体作为METTL3载体促进成骨和抑制脂质生成以治疗绝经后骨质疏松症
Tao Li,Jiangminghao Zhao,Jinghong Yuan et al.
Tao Li et al.
Postmenopausal osteoporosis (PMOP), a prevalent skeletal disorder among women post-menopause, has emerged as a pressing global public health concern. Exosomes derived from serum have exhibited encouraging therapeutic potential in addressing...
Macrophage membrane-coated polydopamine nanomedicine for treating acute lung injury through modulation of neutrophil extracellular traps and M2 macrophage polarization [0.03%]
用于调节中性粒细胞胞外诱捕网和M2型巨噬细胞极化的治疗急性肺损伤的巨噬膜包被聚多巴胺纳米药物
Yuwei Zhao,Xingyu Zhu,Letao Hu et al.
Yuwei Zhao et al.
Acute lung injury (ALI) is a life-threatening pulmonary inflammatory disorder with high morbidity and mortality rates. Effective targeting of damaged lung tissues and regulation of inflammatory dysregulation are major challenges in clinical...
Biomimetic multifunctional nanoparticles for improved radiotherapy and immunotherapy in cancer treatment [0.03%]
仿生多功能纳米粒子在癌症放疗和免疫治疗中的应用
Jiale Chen,Pan Ran,Yizhao Xu et al.
Jiale Chen et al.
Radiotherapy represents a conventional approach in clinical cancer treatment, but suffers from insufficient DNA damage and limited tumor selectivity. Herein, bismuth oxyiodide quantum dots loaded hollow manganese dioxide (MB) nanoparticles ...
Longitudinal multi-omics analysis of the gut-liver axis: Unraveling the molecular mechanisms of metabolic homeostasis regulation by Pd@Pt nanozymes [0.03%]
肠道-肝脏轴的纵向多组学分析：解密Pd@Pt纳米酶调节代谢稳态的分子机制
Yanan Wang,Nan Cheng,Qi Zhang et al.
Yanan Wang et al.
Recently, the nanozyme Pd@Pt has garnered attention due to its notable specific surface area and superior enzyme-like catalytic activity, leading to extensive examination and application in previous studies. However, the comprehensive impac...